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Intake of Lactiplantibacillus plantarum HEAL9 reduces the inflammatory markers soluble fractalkine and CD163 during acute stress : A randomized, double blind, placebo-controlled study

Önning, Gunilla LU ; Hillman, Magnus LU ; Hedin, Maria LU ; Montelius, Caroline LU ; Eriksson, Joakim LU ; Ahrné, Siv LU and Jönsson, Peter (2020) In Physiology and Behavior 225.
Abstract

The intestine and the brain are connected via the brain-gut axis and the intestinal microbiota influences the immune activation and signaling molecules that are involved in the stress response. The aim of the study was to investigate if intake of the probiotic strain Lactiplantibacillus plantarum HEAL9 (LPHEAL9) for four weeks could counteract elevated cortisol and inflammation levels in subjects with chronic stress that are exposed to an acute stress test (Trier Social Stress Test, TSST). Seventy participants were included, and 63 participants completed the study (LPHEAL9, n = 32; placebo, n = 31). Cardiovascular reactivity and cortisol levels were affected by the TSST, but no differences between the groups were observed. Intake of... (More)

The intestine and the brain are connected via the brain-gut axis and the intestinal microbiota influences the immune activation and signaling molecules that are involved in the stress response. The aim of the study was to investigate if intake of the probiotic strain Lactiplantibacillus plantarum HEAL9 (LPHEAL9) for four weeks could counteract elevated cortisol and inflammation levels in subjects with chronic stress that are exposed to an acute stress test (Trier Social Stress Test, TSST). Seventy participants were included, and 63 participants completed the study (LPHEAL9, n = 32; placebo, n = 31). Cardiovascular reactivity and cortisol levels were affected by the TSST, but no differences between the groups were observed. Intake of LPHEAL9 did, however, result in significantly decreased plasma levels of two inflammatory markers (soluble fractalkine and CD163) compared to placebo. In conclusion, intake of LPHEAL9 for four weeks may reduce inflammatory markers coupled to acute stress in chronically stressed individuals.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chemokine, CX3CL1, HPA axis, Psychosocial stress, TSST, Virtual reality
in
Physiology and Behavior
volume
225
article number
113083
publisher
Elsevier
external identifiers
  • pmid:32687924
  • scopus:85088135760
ISSN
0031-9384
DOI
10.1016/j.physbeh.2020.113083
language
English
LU publication?
yes
id
6acb6c30-f43b-4ed7-abdc-25fbb9e69681
date added to LUP
2020-07-27 12:58:19
date last changed
2020-08-05 05:48:23
@article{6acb6c30-f43b-4ed7-abdc-25fbb9e69681,
  abstract     = {<p>The intestine and the brain are connected via the brain-gut axis and the intestinal microbiota influences the immune activation and signaling molecules that are involved in the stress response. The aim of the study was to investigate if intake of the probiotic strain Lactiplantibacillus plantarum HEAL9 (LPHEAL9) for four weeks could counteract elevated cortisol and inflammation levels in subjects with chronic stress that are exposed to an acute stress test (Trier Social Stress Test, TSST). Seventy participants were included, and 63 participants completed the study (LPHEAL9, n = 32; placebo, n = 31). Cardiovascular reactivity and cortisol levels were affected by the TSST, but no differences between the groups were observed. Intake of LPHEAL9 did, however, result in significantly decreased plasma levels of two inflammatory markers (soluble fractalkine and CD163) compared to placebo. In conclusion, intake of LPHEAL9 for four weeks may reduce inflammatory markers coupled to acute stress in chronically stressed individuals.</p>},
  author       = {Önning, Gunilla and Hillman, Magnus and Hedin, Maria and Montelius, Caroline and Eriksson, Joakim and Ahrné, Siv and Jönsson, Peter},
  issn         = {0031-9384},
  language     = {eng},
  publisher    = {Elsevier},
  series       = {Physiology and Behavior},
  title        = {Intake of Lactiplantibacillus plantarum HEAL9 reduces the inflammatory markers soluble fractalkine and CD163 during acute stress : A randomized, double blind, placebo-controlled study},
  url          = {http://dx.doi.org/10.1016/j.physbeh.2020.113083},
  doi          = {10.1016/j.physbeh.2020.113083},
  volume       = {225},
  year         = {2020},
}