Neuroblastoma aggressiveness in relation to sympathetic neuronal differentiation stage.
Mohlin, Sofie LU
; Wigerup, Caroline
LU
and Påhlman, Sven
LU
(2011)
In Seminars in Cancer Biology
21(4).
p.276-282
- Abstract
- Neuroblastoma is a childhood malignancy of the sympathetic neuronal lineage. It is a rare disease, but since it is frequently diagnosed during infancy, neuroblastoma causes life-long medical follow up of those children that survive the disease. It was early recognized that a high tumor cell differentiation stage correlates to favorable clinical stage and positive clinical outcome. Today, highly differentiated tumors are surgically removed and not further treated. Cells of many established human neuroblastoma cell lines have the capacity to differentiate when stimulated properly, and these cell lines have been used as models for studying and understanding central concepts of tumor cell differentiation. One recent aspect of this issue is the... (More)
- Neuroblastoma is a childhood malignancy of the sympathetic neuronal lineage. It is a rare disease, but since it is frequently diagnosed during infancy, neuroblastoma causes life-long medical follow up of those children that survive the disease. It was early recognized that a high tumor cell differentiation stage correlates to favorable clinical stage and positive clinical outcome. Today, highly differentiated tumors are surgically removed and not further treated. Cells of many established human neuroblastoma cell lines have the capacity to differentiate when stimulated properly, and these cell lines have been used as models for studying and understanding central concepts of tumor cell differentiation. One recent aspect of this issue is the observation that tumor cells can dedifferentiate and gain a stem cell-like phenotype during hypoxic conditions, which was first shown in neuroblastoma. Aberrant or blocked differentiation is a central aspect of neuroblastoma genesis. In this review we summarize known genetic and non-genetic events in neuroblastoma that might be coupled to an aberrant sympathetic neuronal differentiation and thereby indirectly influencing tumorigenesis and/or aggressive neuroblastoma behavior. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2168408
- author
- Mohlin, Sofie
LU
; Wigerup, Caroline
LU
and Påhlman, Sven
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Seminars in Cancer Biology
- volume
- 21
- issue
- 4
- pages
- 276 - 282
- publisher
- Academic Press
- external identifiers
-
- wos:000297444700008
- pmid:21945591
- scopus:80655146975
- pmid:21945591
- ISSN
- 1096-3650
- DOI
- 10.1016/j.semcancer.2011.09.002
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular Medicine (013031200)
- id
- 6adb05ad-f742-4aa8-8c1f-ea4319326acb (old id 2168408)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21945591?dopt=Abstract
- date added to LUP
- 2016-04-01 14:43:38
- date last changed
- 2022-01-28 02:14:40
@article{6adb05ad-f742-4aa8-8c1f-ea4319326acb,
abstract = {{Neuroblastoma is a childhood malignancy of the sympathetic neuronal lineage. It is a rare disease, but since it is frequently diagnosed during infancy, neuroblastoma causes life-long medical follow up of those children that survive the disease. It was early recognized that a high tumor cell differentiation stage correlates to favorable clinical stage and positive clinical outcome. Today, highly differentiated tumors are surgically removed and not further treated. Cells of many established human neuroblastoma cell lines have the capacity to differentiate when stimulated properly, and these cell lines have been used as models for studying and understanding central concepts of tumor cell differentiation. One recent aspect of this issue is the observation that tumor cells can dedifferentiate and gain a stem cell-like phenotype during hypoxic conditions, which was first shown in neuroblastoma. Aberrant or blocked differentiation is a central aspect of neuroblastoma genesis. In this review we summarize known genetic and non-genetic events in neuroblastoma that might be coupled to an aberrant sympathetic neuronal differentiation and thereby indirectly influencing tumorigenesis and/or aggressive neuroblastoma behavior.}},
author = {{Mohlin, Sofie and Wigerup, Caroline and Påhlman, Sven}},
issn = {{1096-3650}},
language = {{eng}},
number = {{4}},
pages = {{276--282}},
publisher = {{Academic Press}},
series = {{Seminars in Cancer Biology}},
title = {{Neuroblastoma aggressiveness in relation to sympathetic neuronal differentiation stage.}},
url = {{https://lup.lub.lu.se/search/files/4130351/2540387.pdf}},
doi = {{10.1016/j.semcancer.2011.09.002}},
volume = {{21}},
year = {{2011}},
}