Metabolic engineering for pentose utilization in Saccharomyces cerevisiae
(2007) 108. p.147-177- Abstract
- The introduction of pentose utilization pathways in baker's yeast Saccharomyces cerevisiae is summarized together with metabolic engineering strategies to improve ethanolic pentose fermentation. Bacterial and fungal xylose and arabinose pathways have been expressed in S. cerevisiae but do not generally convey significant ethanolic fermentation traits to this yeast. A large number of rational metabolic engineering strategies directed among others toward sugar transport, initial pentose conversion, the pentose phosphate pathway, and the cellular redox metabolism have been exploited. The directed metabolic engineering approach has often been combined with random approaches including adaptation, mutagenesis, and hybridization. The knowledge... (More)
- The introduction of pentose utilization pathways in baker's yeast Saccharomyces cerevisiae is summarized together with metabolic engineering strategies to improve ethanolic pentose fermentation. Bacterial and fungal xylose and arabinose pathways have been expressed in S. cerevisiae but do not generally convey significant ethanolic fermentation traits to this yeast. A large number of rational metabolic engineering strategies directed among others toward sugar transport, initial pentose conversion, the pentose phosphate pathway, and the cellular redox metabolism have been exploited. The directed metabolic engineering approach has often been combined with random approaches including adaptation, mutagenesis, and hybridization. The knowledge gained about pentose fermentation in S. cerevisiae is primarily limited to genetically and physiologically well-characterized laboratory strains. The translation of this knowledge to strains performing in an industrial context is discussed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/636696
- author
- Hahn-Hägerdal, Bärbel LU ; Karhumaa, Kaisa LU ; Jeppsson, Marie LU and Gorwa-Grauslund, Marie-Francoise LU
- organization
- publishing date
- 2007
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Advances in Biochemical Engineering/Biotechnology
- editor
- Olsson, Lisbeth
- volume
- 108
- pages
- 147 - 177
- publisher
- Springer
- external identifiers
-
- wos:000250578300006
- scopus:34548789083
- ISSN
- 0724-6145
- ISBN
- 978-3-540-73650-9
- DOI
- 10.1007/10_2007_062
- language
- English
- LU publication?
- yes
- id
- 6aea0cc6-7db6-4099-b6e4-ca0e8939e001 (old id 636696)
- date added to LUP
- 2016-04-01 15:58:37
- date last changed
- 2022-03-14 21:15:02
@inbook{6aea0cc6-7db6-4099-b6e4-ca0e8939e001,
abstract = {{The introduction of pentose utilization pathways in baker's yeast Saccharomyces cerevisiae is summarized together with metabolic engineering strategies to improve ethanolic pentose fermentation. Bacterial and fungal xylose and arabinose pathways have been expressed in S. cerevisiae but do not generally convey significant ethanolic fermentation traits to this yeast. A large number of rational metabolic engineering strategies directed among others toward sugar transport, initial pentose conversion, the pentose phosphate pathway, and the cellular redox metabolism have been exploited. The directed metabolic engineering approach has often been combined with random approaches including adaptation, mutagenesis, and hybridization. The knowledge gained about pentose fermentation in S. cerevisiae is primarily limited to genetically and physiologically well-characterized laboratory strains. The translation of this knowledge to strains performing in an industrial context is discussed.}},
author = {{Hahn-Hägerdal, Bärbel and Karhumaa, Kaisa and Jeppsson, Marie and Gorwa-Grauslund, Marie-Francoise}},
booktitle = {{Advances in Biochemical Engineering/Biotechnology}},
editor = {{Olsson, Lisbeth}},
isbn = {{978-3-540-73650-9}},
issn = {{0724-6145}},
language = {{eng}},
pages = {{147--177}},
publisher = {{Springer}},
title = {{Metabolic engineering for pentose utilization in Saccharomyces cerevisiae}},
url = {{http://dx.doi.org/10.1007/10_2007_062}},
doi = {{10.1007/10_2007_062}},
volume = {{108}},
year = {{2007}},
}