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Apathy and anxiety are early markers of Alzheimer's disease

Johansson, Maurits LU ; Stomrud, Erik LU orcid ; Lindberg, Olof LU ; Westman, Eric ; Johansson, Per Mårten LU orcid ; van Westen, Danielle LU orcid ; Mattsson, Niklas LU orcid and Hansson, Oskar LU orcid (2020) In Neurobiology of Aging 85. p.74-82
Abstract

In this study, we investigated associations between neuropsychiatric symptoms (i.e., apathy, anxiety, and depression) and cerebral atrophy, white matter lesions (WML), beta-amyloid (Aβ) deposition, and cognitive decline in a nondemented sample. 104 cognitively unimpaired and 53 subjects with mild cognitive impairment were followed for up to 4 years within the Swedish BioFINDER study. Neuropsychiatric assessments included the Hospital Anxiety and Depression Scale and the Apathy Evaluation Scale. Magnetic resonance imaging and 18F-flutemetamol-positron emission tomography quantified brain atrophy, WML, and Aβ deposition. Mini-Mental State Examination assessed longitudinal global cognition. Regression analyses were used to test for... (More)

In this study, we investigated associations between neuropsychiatric symptoms (i.e., apathy, anxiety, and depression) and cerebral atrophy, white matter lesions (WML), beta-amyloid (Aβ) deposition, and cognitive decline in a nondemented sample. 104 cognitively unimpaired and 53 subjects with mild cognitive impairment were followed for up to 4 years within the Swedish BioFINDER study. Neuropsychiatric assessments included the Hospital Anxiety and Depression Scale and the Apathy Evaluation Scale. Magnetic resonance imaging and 18F-flutemetamol-positron emission tomography quantified brain atrophy, WML, and Aβ deposition. Mini-Mental State Examination assessed longitudinal global cognition. Regression analyses were used to test for associations. Apathy and anxiety were shown related to Aβ deposition and predicted cognitive decline. Anxiety also interacted with amyloid status to predict faster cognitive deterioration. Apathy was further related to frontotemporal and subcortical atrophy, as well as WML. To conclude, the associations between apathy and anxiety with Aβ deposition and cognitive decline point to these symptoms as early clinical manifestations of Alzheimer's disease.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurobiology of Aging
volume
85
pages
74 - 82
publisher
Elsevier
external identifiers
  • scopus:85075426913
  • pmid:31735378
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2019.10.008
language
English
LU publication?
yes
additional info
Copyright © 2019 Elsevier Inc. All rights reserved.
id
6b77ff73-7b9b-44ab-baff-912209c78a1f
date added to LUP
2019-11-21 13:41:56
date last changed
2025-04-26 02:22:54
@article{6b77ff73-7b9b-44ab-baff-912209c78a1f,
  abstract     = {{<p>In this study, we investigated associations between neuropsychiatric symptoms (i.e., apathy, anxiety, and depression) and cerebral atrophy, white matter lesions (WML), beta-amyloid (Aβ) deposition, and cognitive decline in a nondemented sample. 104 cognitively unimpaired and 53 subjects with mild cognitive impairment were followed for up to 4 years within the Swedish BioFINDER study. Neuropsychiatric assessments included the Hospital Anxiety and Depression Scale and the Apathy Evaluation Scale. Magnetic resonance imaging and 18F-flutemetamol-positron emission tomography quantified brain atrophy, WML, and Aβ deposition. Mini-Mental State Examination assessed longitudinal global cognition. Regression analyses were used to test for associations. Apathy and anxiety were shown related to Aβ deposition and predicted cognitive decline. Anxiety also interacted with amyloid status to predict faster cognitive deterioration. Apathy was further related to frontotemporal and subcortical atrophy, as well as WML. To conclude, the associations between apathy and anxiety with Aβ deposition and cognitive decline point to these symptoms as early clinical manifestations of Alzheimer's disease.</p>}},
  author       = {{Johansson, Maurits and Stomrud, Erik and Lindberg, Olof and Westman, Eric and Johansson, Per Mårten and van Westen, Danielle and Mattsson, Niklas and Hansson, Oskar}},
  issn         = {{1558-1497}},
  language     = {{eng}},
  pages        = {{74--82}},
  publisher    = {{Elsevier}},
  series       = {{Neurobiology of Aging}},
  title        = {{Apathy and anxiety are early markers of Alzheimer's disease}},
  url          = {{http://dx.doi.org/10.1016/j.neurobiolaging.2019.10.008}},
  doi          = {{10.1016/j.neurobiolaging.2019.10.008}},
  volume       = {{85}},
  year         = {{2020}},
}