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APC-PCI complex levels for screening of AAA in patients with peripheral atherosclerosis.

Zarrouk, Moncef LU ; Keshavarz, Kave ; Lindblad, Bengt LU and Gottsäter, Anders LU (2013) In Journal of Thrombosis and Thrombolysis 36(4). p.495-500
Abstract
To evaluate the use of activated protein C-protein C inhibitor (APC-PCI) complex levels for detection of abdominal aortic aneurysm (AAA) in patients with peripheral atherosclerotic disease (PAD). APC-PCI levels and aortic diameter evaluated in 511 PAD patients without previously known AAA followed-up concerning survival for 4.8(0.5) years. AAA was found in 13 % of patients. Aortic diameter correlated (r = 0.138; p = 0.002) with APC-PCI levels which were higher (0.40[0.45] vs. 0.30[0.49] μg/l; p = 0.004) in patients with AAA. This difference persisted in multivariate analysis (p = 0.029). A threshold value of APC-PCI ≥0.15 μg/L showed a specificity of 11 %, a sensitivity of 97 % and a negative predictive value of 96 % for an AAA diagnosis.... (More)
To evaluate the use of activated protein C-protein C inhibitor (APC-PCI) complex levels for detection of abdominal aortic aneurysm (AAA) in patients with peripheral atherosclerotic disease (PAD). APC-PCI levels and aortic diameter evaluated in 511 PAD patients without previously known AAA followed-up concerning survival for 4.8(0.5) years. AAA was found in 13 % of patients. Aortic diameter correlated (r = 0.138; p = 0.002) with APC-PCI levels which were higher (0.40[0.45] vs. 0.30[0.49] μg/l; p = 0.004) in patients with AAA. This difference persisted in multivariate analysis (p = 0.029). A threshold value of APC-PCI ≥0.15 μg/L showed a specificity of 11 %, a sensitivity of 97 % and a negative predictive value of 96 % for an AAA diagnosis. APC-PCI levels were higher in patients with AAA, and showed high sensitivity but low specificity for the diagnosis and can therefore not be considered as a screening tool in PAD patients. An AAA prevalence of 13 % in patients with PAD indicates a need for AAA screening within this population. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Thrombosis and Thrombolysis
volume
36
issue
4
pages
495 - 500
publisher
Springer
external identifiers
  • wos:000326802500019
  • pmid:23354969
  • scopus:84889085476
  • pmid:23354969
ISSN
1573-742X
DOI
10.1007/s11239-013-0871-6
language
English
LU publication?
yes
id
6ba55999-c88f-4bb2-b4a1-e80328fa7bb3 (old id 3438244)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23354969?dopt=Abstract
date added to LUP
2016-04-01 09:48:20
date last changed
2022-01-25 08:53:16
@article{6ba55999-c88f-4bb2-b4a1-e80328fa7bb3,
  abstract     = {{To evaluate the use of activated protein C-protein C inhibitor (APC-PCI) complex levels for detection of abdominal aortic aneurysm (AAA) in patients with peripheral atherosclerotic disease (PAD). APC-PCI levels and aortic diameter evaluated in 511 PAD patients without previously known AAA followed-up concerning survival for 4.8(0.5) years. AAA was found in 13 % of patients. Aortic diameter correlated (r = 0.138; p = 0.002) with APC-PCI levels which were higher (0.40[0.45] vs. 0.30[0.49] μg/l; p = 0.004) in patients with AAA. This difference persisted in multivariate analysis (p = 0.029). A threshold value of APC-PCI ≥0.15 μg/L showed a specificity of 11 %, a sensitivity of 97 % and a negative predictive value of 96 % for an AAA diagnosis. APC-PCI levels were higher in patients with AAA, and showed high sensitivity but low specificity for the diagnosis and can therefore not be considered as a screening tool in PAD patients. An AAA prevalence of 13 % in patients with PAD indicates a need for AAA screening within this population.}},
  author       = {{Zarrouk, Moncef and Keshavarz, Kave and Lindblad, Bengt and Gottsäter, Anders}},
  issn         = {{1573-742X}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{495--500}},
  publisher    = {{Springer}},
  series       = {{Journal of Thrombosis and Thrombolysis}},
  title        = {{APC-PCI complex levels for screening of AAA in patients with peripheral atherosclerosis.}},
  url          = {{http://dx.doi.org/10.1007/s11239-013-0871-6}},
  doi          = {{10.1007/s11239-013-0871-6}},
  volume       = {{36}},
  year         = {{2013}},
}