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Disease duration, age at diagnosis and organ damage are important factors for cardiovascular disease in SLE

Nived, Ola LU ; Ingvarsson, Ragnar Freyr LU ; Jöud, Anna LU ; Linge, Petrus LU ; Tydén, Helena LU ; Jönsen, Andreas LU and Bengtsson, Anders A LU (2020) In Lupus science & medicine 7.
Abstract

OBJECTIVE: To report the incidence rate ratios (IRR) of acute myocardial infarctions (AMI) and cerebrovascular events (CVE) in incident SLE cases from a defined population. To study the risk factors for cardiovascular events in all patients with SLE at our unit.

METHODS: Patients with SLE diagnosed from 1981 to 2006 were followed through to 2016. IRRs of AMI and CVE were calculated. The AMI and CVE incidence patterns for patients with SLE were studied in relation to hypertension, smoking, renal dysfunction, anticardiolipin (aCL) antibodies at diagnosis, disease duration and organ damage before an event.

RESULTS: 262 patients with SLE were included in the study; of these 175 were from the defined population. Overall, 37 AMI... (More)

OBJECTIVE: To report the incidence rate ratios (IRR) of acute myocardial infarctions (AMI) and cerebrovascular events (CVE) in incident SLE cases from a defined population. To study the risk factors for cardiovascular events in all patients with SLE at our unit.

METHODS: Patients with SLE diagnosed from 1981 to 2006 were followed through to 2016. IRRs of AMI and CVE were calculated. The AMI and CVE incidence patterns for patients with SLE were studied in relation to hypertension, smoking, renal dysfunction, anticardiolipin (aCL) antibodies at diagnosis, disease duration and organ damage before an event.

RESULTS: 262 patients with SLE were included in the study; of these 175 were from the defined population. Overall, 37 AMI and 44 CVE were recorded. An increased IRR of 3 for AMI was found (p<0.001). Smoking, hypertension and reduced renal function were risk factors for AMI. An increased IRR of 3.3 for ischaemic CVE was found for women (p<0.001). Hypertension and aCL were risk factors for CVE. Organ damage before events was increased.

CONCLUSIONS: Cardiovascular events are increased in SLE and are associated with hypertension, smoking and increased damage rate.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Lupus science & medicine
volume
7
article number
e000398
publisher
BMJ Publishing Group
external identifiers
  • pmid:32587062
ISSN
2053-8790
DOI
10.1136/lupus-2020-000398
language
English
LU publication?
yes
additional info
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
id
6c16e994-2001-452a-ad2f-39858d0729ab
date added to LUP
2020-08-25 10:04:27
date last changed
2020-08-26 04:06:09
@article{6c16e994-2001-452a-ad2f-39858d0729ab,
  abstract     = {<p>OBJECTIVE: To report the incidence rate ratios (IRR) of acute myocardial infarctions (AMI) and cerebrovascular events (CVE) in incident SLE cases from a defined population. To study the risk factors for cardiovascular events in all patients with SLE at our unit.</p><p>METHODS: Patients with SLE diagnosed from 1981 to 2006 were followed through to 2016. IRRs of AMI and CVE were calculated. The AMI and CVE incidence patterns for patients with SLE were studied in relation to hypertension, smoking, renal dysfunction, anticardiolipin (aCL) antibodies at diagnosis, disease duration and organ damage before an event.</p><p>RESULTS: 262 patients with SLE were included in the study; of these 175 were from the defined population. Overall, 37 AMI and 44 CVE were recorded. An increased IRR of 3 for AMI was found (p&lt;0.001). Smoking, hypertension and reduced renal function were risk factors for AMI. An increased IRR of 3.3 for ischaemic CVE was found for women (p&lt;0.001). Hypertension and aCL were risk factors for CVE. Organ damage before events was increased.</p><p>CONCLUSIONS: Cardiovascular events are increased in SLE and are associated with hypertension, smoking and increased damage rate.</p>},
  author       = {Nived, Ola and Ingvarsson, Ragnar Freyr and Jöud, Anna and Linge, Petrus and Tydén, Helena and Jönsen, Andreas and Bengtsson, Anders A},
  issn         = {2053-8790},
  language     = {eng},
  publisher    = {BMJ Publishing Group},
  series       = {Lupus science & medicine},
  title        = {Disease duration, age at diagnosis and organ damage are important factors for cardiovascular disease in SLE},
  url          = {http://dx.doi.org/10.1136/lupus-2020-000398},
  doi          = {10.1136/lupus-2020-000398},
  volume       = {7},
  year         = {2020},
}