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Impact of family history of cancer on risk and mortality of second cancers in patients with prostate cancer

Chattopadhyay, Subhayan LU ; Hemminki, Otto; Försti, Asta LU ; Sundquist, Kristina LU ; Sundquist, Jan LU and Hemminki, Kari LU (2019) In Prostate Cancer and Prostatic Diseases 22(1). p.143-149
Abstract

Background: Survival rates are increasing in patients with prostate cancer, and second primary cancers (SPCs) are becoming more common in these patients. However, the etiology and clinical consequences of SPCs are not well-known. We define the impact of family history on SPC and causes of mortality in these patients. Patients and methods: A nation-wide cohort study based on the Swedish Family-Cancer Database covering 4.4 million men and 80,449 prostate cancers diagnosed between 1990 and 2015. Relative risks (RRs) and cumulative incidence for SPCs and for familial SPC were calculated for prostate cancer patients. Results: SPC was diagnosed in 6,396 men and more than a third of these patients had a first-degree family history of any... (More)

Background: Survival rates are increasing in patients with prostate cancer, and second primary cancers (SPCs) are becoming more common in these patients. However, the etiology and clinical consequences of SPCs are not well-known. We define the impact of family history on SPC and causes of mortality in these patients. Patients and methods: A nation-wide cohort study based on the Swedish Family-Cancer Database covering 4.4 million men and 80,449 prostate cancers diagnosed between 1990 and 2015. Relative risks (RRs) and cumulative incidence for SPCs and for familial SPC were calculated for prostate cancer patients. Results: SPC was diagnosed in 6,396 men and more than a third of these patients had a first-degree family history of any cancer; the familial risk was 1.37 (95% CI: 1.27–1.40), compared to 1.10 (1.08–1.16), without a family history. Cumulative incidence by the age of 83 years reached 21% for prostate cancer alone, 28% in those with SPC, and 35% in patients with SPC and family history. Family history was associated with the risk of seven specific SPCs, including colorectal, lung, kidney, bladder and skin (both melanoma and squamous cell) cancers, and leukemia. Colorectal and lung cancers were common SPCs, and family history doubled the risk of these SPCs. In patients with SPC, half of all causes of death were due to SPC and only 12.77% were due to prostate cancer. Most deaths in SPC were caused by lung and colorectal cancers. Conclusions: SPCs were an important cause of death in patients with prostate cancer and family history was an important risk factor for SPCs. Prevention of SPC should be essential when prostate cancer survival rates are being improved and this could start by conducting a thorough assessment of family history at the time of prostate cancer diagnosis.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Prostate Cancer and Prostatic Diseases
volume
22
issue
1
pages
143 - 149
publisher
Nature Publishing Group
external identifiers
  • scopus:85053434022
ISSN
1365-7852
DOI
10.1038/s41391-018-0089-y
language
English
LU publication?
yes
id
6c566294-78a8-4ed3-858b-4c4bcbd68605
date added to LUP
2018-10-24 13:02:24
date last changed
2019-05-27 15:49:18
@article{6c566294-78a8-4ed3-858b-4c4bcbd68605,
  abstract     = {<p>Background: Survival rates are increasing in patients with prostate cancer, and second primary cancers (SPCs) are becoming more common in these patients. However, the etiology and clinical consequences of SPCs are not well-known. We define the impact of family history on SPC and causes of mortality in these patients. Patients and methods: A nation-wide cohort study based on the Swedish Family-Cancer Database covering 4.4 million men and 80,449 prostate cancers diagnosed between 1990 and 2015. Relative risks (RRs) and cumulative incidence for SPCs and for familial SPC were calculated for prostate cancer patients. Results: SPC was diagnosed in 6,396 men and more than a third of these patients had a first-degree family history of any cancer; the familial risk was 1.37 (95% CI: 1.27–1.40), compared to 1.10 (1.08–1.16), without a family history. Cumulative incidence by the age of 83 years reached 21% for prostate cancer alone, 28% in those with SPC, and 35% in patients with SPC and family history. Family history was associated with the risk of seven specific SPCs, including colorectal, lung, kidney, bladder and skin (both melanoma and squamous cell) cancers, and leukemia. Colorectal and lung cancers were common SPCs, and family history doubled the risk of these SPCs. In patients with SPC, half of all causes of death were due to SPC and only 12.77% were due to prostate cancer. Most deaths in SPC were caused by lung and colorectal cancers. Conclusions: SPCs were an important cause of death in patients with prostate cancer and family history was an important risk factor for SPCs. Prevention of SPC should be essential when prostate cancer survival rates are being improved and this could start by conducting a thorough assessment of family history at the time of prostate cancer diagnosis.</p>},
  author       = {Chattopadhyay, Subhayan and Hemminki, Otto and Försti, Asta and Sundquist, Kristina and Sundquist, Jan and Hemminki, Kari},
  issn         = {1365-7852},
  language     = {eng},
  number       = {1},
  pages        = {143--149},
  publisher    = {Nature Publishing Group},
  series       = {Prostate Cancer and Prostatic Diseases},
  title        = {Impact of family history of cancer on risk and mortality of second cancers in patients with prostate cancer},
  url          = {http://dx.doi.org/10.1038/s41391-018-0089-y},
  volume       = {22},
  year         = {2019},
}