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Silica seed particles improve the efficiency and throughput of nanoparticle acoustic trapping

Havers, Megan LU orcid ; Baasch, Thierry LU ; Lenshof, Andreas LU ; Evander, Mikael LU and Laurell, Thomas LU (2024) In Physical Review Applied 21(3).
Abstract

Silica has rarely been used as a seed particle material in acoustic trapping of nanoparticles. Here we use fluorescent nanoparticles, which are frequently used as a model system, to demonstrate that throughput and nanoparticle trapping efficiency can be improved by using silica seed particles as opposed to traditionally used polystyrene seed particles. The 10 times larger dipole scattering coefficient of silica seed particles compared with polystyrene seed particles in water leads to a higher retention force against fluid flow and thus enables higher throughput. Seed particles retained at an actuation voltage of approximately 10 V p.p. can withstand flow rates up to 2100 ± 200 μl/min for silica and 200 ± 50 μl/min for polystyrene.... (More)

Silica has rarely been used as a seed particle material in acoustic trapping of nanoparticles. Here we use fluorescent nanoparticles, which are frequently used as a model system, to demonstrate that throughput and nanoparticle trapping efficiency can be improved by using silica seed particles as opposed to traditionally used polystyrene seed particles. The 10 times larger dipole scattering coefficient of silica seed particles compared with polystyrene seed particles in water leads to a higher retention force against fluid flow and thus enables higher throughput. Seed particles retained at an actuation voltage of approximately 10 V p.p. can withstand flow rates up to 2100 ± 200 μl/min for silica and 200 ± 50 μl/min for polystyrene. Furthermore, silica is found to be 40%-2000% more efficient (number of trapped nanoparticles as measured by fluorescent intensity) than polystyrene seed particles in trapping 270-nm polystyrene nanoparticles from suspensions of 1010-1011 particles/ml. Moreover, after enriching nanoparticles into a silica seed particle cluster, the washing flow rate can be increased from 30 μl/min to 200 μl/min (the flow rate at which polystyrene clusters are unstable), halving the total sample processing time without losing the silica seed particle cluster or compromising the nanoparticle trapping efficiency. Thus, material properties (particularly density) of the seed particles are critical to both nanoparticle trapping efficiency and throughput.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physical Review Applied
volume
21
issue
3
article number
034016
publisher
American Physical Society
external identifiers
  • scopus:85187540458
ISSN
2331-7019
DOI
10.1103/PhysRevApplied.21.034016
language
English
LU publication?
yes
id
6cca7d2a-2ff6-48e7-b7ab-6d349135a86c
date added to LUP
2024-04-10 13:40:53
date last changed
2024-04-10 13:42:20
@article{6cca7d2a-2ff6-48e7-b7ab-6d349135a86c,
  abstract     = {{<p>Silica has rarely been used as a seed particle material in acoustic trapping of nanoparticles. Here we use fluorescent nanoparticles, which are frequently used as a model system, to demonstrate that throughput and nanoparticle trapping efficiency can be improved by using silica seed particles as opposed to traditionally used polystyrene seed particles. The 10 times larger dipole scattering coefficient of silica seed particles compared with polystyrene seed particles in water leads to a higher retention force against fluid flow and thus enables higher throughput. Seed particles retained at an actuation voltage of approximately 10 V p.p. can withstand flow rates up to 2100 ± 200 μl/min for silica and 200 ± 50 μl/min for polystyrene. Furthermore, silica is found to be 40%-2000% more efficient (number of trapped nanoparticles as measured by fluorescent intensity) than polystyrene seed particles in trapping 270-nm polystyrene nanoparticles from suspensions of 1010-1011 particles/ml. Moreover, after enriching nanoparticles into a silica seed particle cluster, the washing flow rate can be increased from 30 μl/min to 200 μl/min (the flow rate at which polystyrene clusters are unstable), halving the total sample processing time without losing the silica seed particle cluster or compromising the nanoparticle trapping efficiency. Thus, material properties (particularly density) of the seed particles are critical to both nanoparticle trapping efficiency and throughput.</p>}},
  author       = {{Havers, Megan and Baasch, Thierry and Lenshof, Andreas and Evander, Mikael and Laurell, Thomas}},
  issn         = {{2331-7019}},
  language     = {{eng}},
  number       = {{3}},
  publisher    = {{American Physical Society}},
  series       = {{Physical Review Applied}},
  title        = {{Silica seed particles improve the efficiency and throughput of nanoparticle acoustic trapping}},
  url          = {{http://dx.doi.org/10.1103/PhysRevApplied.21.034016}},
  doi          = {{10.1103/PhysRevApplied.21.034016}},
  volume       = {{21}},
  year         = {{2024}},
}