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Fabrication of sample target plate for MALDI-TOF MS using proton beam writing

Ressine, Anton LU ; Auzelyte, Vaida LU ; Kristiansson, Per LU ; Marko-Varga, György LU and Laurell, Thomas LU (2006) In Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms 249(1-2). p.715-718
Abstract
Ion beam irradiation of silicon followed by electrochemical etching has been used to produce fluid anchor points on a sample target plate for matrix assisted laser desorption ionization mass spectrometry. Non-porous areas on the fabricated target plate serve as anchor points for sample deposition. High hydrophobicity of the macroporous silicon surface surrounding anchor points intrinsically led to a better sample confinement and gave the possibility to deposit large volumes of sample at predefined spot areas, improving the sensitivity in bioanalyte readout. We also have found that irradiation with beam fluences lower than 1014 cm−2 led to the enhanced anodization rate producing inverse structures.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
MALDI-TOF MS analysis, Anchor chip, Sample target, Superhydrophobic surface, Porous silicon, Proton beam writing
in
Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
volume
249
issue
1-2
pages
715 - 718
publisher
Elsevier
external identifiers
  • wos:000239545000173
  • scopus:33745872225
ISSN
0168-583X
DOI
10.1016/j.nimb.2006.03.124
language
English
LU publication?
yes
id
6cf3532c-ae37-4d87-83a0-8bd5d75c0f45 (old id 748857)
date added to LUP
2007-12-13 14:48:07
date last changed
2019-02-20 08:06:30
@article{6cf3532c-ae37-4d87-83a0-8bd5d75c0f45,
  abstract     = {Ion beam irradiation of silicon followed by electrochemical etching has been used to produce fluid anchor points on a sample target plate for matrix assisted laser desorption ionization mass spectrometry. Non-porous areas on the fabricated target plate serve as anchor points for sample deposition. High hydrophobicity of the macroporous silicon surface surrounding anchor points intrinsically led to a better sample confinement and gave the possibility to deposit large volumes of sample at predefined spot areas, improving the sensitivity in bioanalyte readout. We also have found that irradiation with beam fluences lower than 1014 cm−2 led to the enhanced anodization rate producing inverse structures.},
  author       = {Ressine, Anton and Auzelyte, Vaida and Kristiansson, Per and Marko-Varga, György and Laurell, Thomas},
  issn         = {0168-583X},
  keyword      = {MALDI-TOF MS analysis,Anchor chip,Sample target,Superhydrophobic surface,Porous silicon,Proton beam writing},
  language     = {eng},
  number       = {1-2},
  pages        = {715--718},
  publisher    = {Elsevier},
  series       = {Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms},
  title        = {Fabrication of sample target plate for MALDI-TOF MS using proton beam writing},
  url          = {http://dx.doi.org/10.1016/j.nimb.2006.03.124},
  volume       = {249},
  year         = {2006},
}