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Cerebral blood flow in white matter is correlated with systolic blood pressure and EEG in senile dementia of the Alzheimer type

Siennicki-Lantz, Arkadiusz LU orcid ; Lilja, Bo ; Rosén, Ingmar LU and Elmståhl, Sölve LU (1998) In Dementia and Geriatric Cognitive Disorders 9(1). p.29-38
Abstract

The presence and functional significance of white matter lesions in the ageing brain and in dementia as well as their relation to blood pressure are often discussed. The aim of this study was to evaluate cerebral blood flow in white matter (WMCBF) and its relation to systemic blood pressure and multichannel EEG. WMCBF was measured in 24 elderly women with senile dementia of Alzheimer's type (SDAT, median age 85.5, range 68-93) and 20 age-matched controls (median age 86.0, range 79-93) using 99mTc-HMPAO single photon emission CT. A significant low WMCBF could be observed in all analysed regions in SDAT subjects compared to controls, with the greatest decline in the posterior region (parietotemporo-occipital area). Correlations... (More)

The presence and functional significance of white matter lesions in the ageing brain and in dementia as well as their relation to blood pressure are often discussed. The aim of this study was to evaluate cerebral blood flow in white matter (WMCBF) and its relation to systemic blood pressure and multichannel EEG. WMCBF was measured in 24 elderly women with senile dementia of Alzheimer's type (SDAT, median age 85.5, range 68-93) and 20 age-matched controls (median age 86.0, range 79-93) using 99mTc-HMPAO single photon emission CT. A significant low WMCBF could be observed in all analysed regions in SDAT subjects compared to controls, with the greatest decline in the posterior region (parietotemporo-occipital area). Correlations between quantified EEG from the posterior regions and WMCBF were seen. Systolic blood pressure was significantly lower in the SDAT group and was positively correlated with WMCBF in the posterior and anterior brain regions. Whether low systemic blood pressure is the result of cerebral dysfunction is unclear.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, Blood pressure, Dementia, senile, Elderly, Electroencephalography, Single photon emission computed tomography
in
Dementia and Geriatric Cognitive Disorders
volume
9
issue
1
pages
10 pages
publisher
Karger
external identifiers
  • scopus:0031972837
  • pmid:9469263
ISSN
1420-8008
DOI
10.1159/000017019
language
English
LU publication?
yes
id
6d41dd23-59c3-4789-82aa-ddb2c096d3a0
date added to LUP
2019-06-19 11:16:55
date last changed
2024-05-14 14:52:23
@article{6d41dd23-59c3-4789-82aa-ddb2c096d3a0,
  abstract     = {{<p>The presence and functional significance of white matter lesions in the ageing brain and in dementia as well as their relation to blood pressure are often discussed. The aim of this study was to evaluate cerebral blood flow in white matter (WMCBF) and its relation to systemic blood pressure and multichannel EEG. WMCBF was measured in 24 elderly women with senile dementia of Alzheimer's type (SDAT, median age 85.5, range 68-93) and 20 age-matched controls (median age 86.0, range 79-93) using <sup>99m</sup>Tc-HMPAO single photon emission CT. A significant low WMCBF could be observed in all analysed regions in SDAT subjects compared to controls, with the greatest decline in the posterior region (parietotemporo-occipital area). Correlations between quantified EEG from the posterior regions and WMCBF were seen. Systolic blood pressure was significantly lower in the SDAT group and was positively correlated with WMCBF in the posterior and anterior brain regions. Whether low systemic blood pressure is the result of cerebral dysfunction is unclear.</p>}},
  author       = {{Siennicki-Lantz, Arkadiusz and Lilja, Bo and Rosén, Ingmar and Elmståhl, Sölve}},
  issn         = {{1420-8008}},
  keywords     = {{Alzheimer's disease; Blood pressure; Dementia, senile; Elderly; Electroencephalography; Single photon emission computed tomography}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{29--38}},
  publisher    = {{Karger}},
  series       = {{Dementia and Geriatric Cognitive Disorders}},
  title        = {{Cerebral blood flow in white matter is correlated with systolic blood pressure and EEG in senile dementia of the Alzheimer type}},
  url          = {{http://dx.doi.org/10.1159/000017019}},
  doi          = {{10.1159/000017019}},
  volume       = {{9}},
  year         = {{1998}},
}