Expression of cyclins E, A, and B, and prognosis in lymph node-negative breast cancer
Kuhling, H ; Alm, Per LU ; Olsson, Håkan LU
; Fernö, Mårten
LU
; Baldetorp, Bo
LU
; Parwaresch, R
and Rudolph, P
(2003)
In Journal of Pathology
199(4).
p.424-431
- Abstract
- Unexpected outcomes in breast cancer demand a refinement of prognostic criteria. This study therefore investigated the prognostic relevance of cyclin expression in a cohort of 332 T1-T2 NO infiltrating ductal carcinomas with long-term follow-up (median 99 months). By univariate analysis, tumour size, histopathological grade, hormone receptor content, cyclin E, cyclin B, and the Ki-S5 (Ki-67) index significantly predicted disease-specific and metastasis-free survival. Cyclin A did not achieve statistical significance. In a multivariate analysis, both cyclin E [relative risk (RR) 2.01, p = 0.021] and cyclin B (RR 1.85, p = 0.033) were selected as independent prognosticators of metastasis-free survival when the Ki-67 index was omitted, but... (More)
- Unexpected outcomes in breast cancer demand a refinement of prognostic criteria. This study therefore investigated the prognostic relevance of cyclin expression in a cohort of 332 T1-T2 NO infiltrating ductal carcinomas with long-term follow-up (median 99 months). By univariate analysis, tumour size, histopathological grade, hormone receptor content, cyclin E, cyclin B, and the Ki-S5 (Ki-67) index significantly predicted disease-specific and metastasis-free survival. Cyclin A did not achieve statistical significance. In a multivariate analysis, both cyclin E [relative risk (RR) 2.01, p = 0.021] and cyclin B (RR 1.85, p = 0.033) were selected as independent prognosticators of metastasis-free survival when the Ki-67 index was omitted, but (only cyclin E expression was associated with disease-specific survival (RR 2.56, p = 0.006). When Ki-67 was included as a covariate, cyclin E lost its significance with respect to disease-specific survival but remained significant for metastasis-free survival. In an analogous analysis including Ki-67, the number of concurrently overexpressed cyclins did not attain statistical significance regarding disease-specific survival but was selected as the leading predictor of metastatic disease. It is concluded that combined overexpression of cyclins may imply genetic instability enhancing metastatic potential, but that survival ultimately depends on the proliferative activity of tumour cells. Copyright (C) 2003 John Wiley Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/315158
- author
- Kuhling, H
; Alm, Per
LU
; Olsson, Håkan
LU
; Fernö, Mårten
LU
; Baldetorp, Bo
LU
; Parwaresch, R
and Rudolph, P
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- prognosis, breast cancer, immunohistochemistry, proliferation, Ki-S5, cyclin B, cyclin E, cyclin A, multivariate study
- in
- Journal of Pathology
- volume
- 199
- issue
- 4
- pages
- 424 - 431
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000181973100003
- pmid:12635132
- scopus:0041379477
- pmid:12635132
- ISSN
- 0022-3417
- DOI
- 10.1002/path.1322
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000)
- id
- 6d94fbc8-b969-40d8-af6f-9723532fc8d0 (old id 315158)
- date added to LUP
- 2016-04-01 12:24:58
- date last changed
- 2022-01-27 03:27:25
@article{6d94fbc8-b969-40d8-af6f-9723532fc8d0,
abstract = {{Unexpected outcomes in breast cancer demand a refinement of prognostic criteria. This study therefore investigated the prognostic relevance of cyclin expression in a cohort of 332 T1-T2 NO infiltrating ductal carcinomas with long-term follow-up (median 99 months). By univariate analysis, tumour size, histopathological grade, hormone receptor content, cyclin E, cyclin B, and the Ki-S5 (Ki-67) index significantly predicted disease-specific and metastasis-free survival. Cyclin A did not achieve statistical significance. In a multivariate analysis, both cyclin E [relative risk (RR) 2.01, p = 0.021] and cyclin B (RR 1.85, p = 0.033) were selected as independent prognosticators of metastasis-free survival when the Ki-67 index was omitted, but (only cyclin E expression was associated with disease-specific survival (RR 2.56, p = 0.006). When Ki-67 was included as a covariate, cyclin E lost its significance with respect to disease-specific survival but remained significant for metastasis-free survival. In an analogous analysis including Ki-67, the number of concurrently overexpressed cyclins did not attain statistical significance regarding disease-specific survival but was selected as the leading predictor of metastatic disease. It is concluded that combined overexpression of cyclins may imply genetic instability enhancing metastatic potential, but that survival ultimately depends on the proliferative activity of tumour cells. Copyright (C) 2003 John Wiley Sons, Ltd.}},
author = {{Kuhling, H and Alm, Per and Olsson, Håkan and Fernö, Mårten and Baldetorp, Bo and Parwaresch, R and Rudolph, P}},
issn = {{0022-3417}},
keywords = {{prognosis; breast cancer; immunohistochemistry; proliferation; Ki-S5; cyclin B; cyclin E; cyclin A; multivariate study}},
language = {{eng}},
number = {{4}},
pages = {{424--431}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Pathology}},
title = {{Expression of cyclins E, A, and B, and prognosis in lymph node-negative breast cancer}},
url = {{http://dx.doi.org/10.1002/path.1322}},
doi = {{10.1002/path.1322}},
volume = {{199}},
year = {{2003}},
}