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Expression of cyclins E, A, and B, and prognosis in lymph node-negative breast cancer

Kuhling, H; Alm, Per LU ; Olsson, Håkan LU ; Fernö, Mårten LU ; Baldetorp, Bo LU ; Parwaresch, R and Rudolph, P (2003) In Journal of Pathology 199(4). p.424-431
Abstract
Unexpected outcomes in breast cancer demand a refinement of prognostic criteria. This study therefore investigated the prognostic relevance of cyclin expression in a cohort of 332 T1-T2 NO infiltrating ductal carcinomas with long-term follow-up (median 99 months). By univariate analysis, tumour size, histopathological grade, hormone receptor content, cyclin E, cyclin B, and the Ki-S5 (Ki-67) index significantly predicted disease-specific and metastasis-free survival. Cyclin A did not achieve statistical significance. In a multivariate analysis, both cyclin E [relative risk (RR) 2.01, p = 0.021] and cyclin B (RR 1.85, p = 0.033) were selected as independent prognosticators of metastasis-free survival when the Ki-67 index was omitted, but... (More)
Unexpected outcomes in breast cancer demand a refinement of prognostic criteria. This study therefore investigated the prognostic relevance of cyclin expression in a cohort of 332 T1-T2 NO infiltrating ductal carcinomas with long-term follow-up (median 99 months). By univariate analysis, tumour size, histopathological grade, hormone receptor content, cyclin E, cyclin B, and the Ki-S5 (Ki-67) index significantly predicted disease-specific and metastasis-free survival. Cyclin A did not achieve statistical significance. In a multivariate analysis, both cyclin E [relative risk (RR) 2.01, p = 0.021] and cyclin B (RR 1.85, p = 0.033) were selected as independent prognosticators of metastasis-free survival when the Ki-67 index was omitted, but (only cyclin E expression was associated with disease-specific survival (RR 2.56, p = 0.006). When Ki-67 was included as a covariate, cyclin E lost its significance with respect to disease-specific survival but remained significant for metastasis-free survival. In an analogous analysis including Ki-67, the number of concurrently overexpressed cyclins did not attain statistical significance regarding disease-specific survival but was selected as the leading predictor of metastatic disease. It is concluded that combined overexpression of cyclins may imply genetic instability enhancing metastatic potential, but that survival ultimately depends on the proliferative activity of tumour cells. Copyright (C) 2003 John Wiley Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prognosis, breast cancer, immunohistochemistry, proliferation, Ki-S5, cyclin B, cyclin E, cyclin A, multivariate study
in
Journal of Pathology
volume
199
issue
4
pages
424 - 431
publisher
John Wiley & Sons
external identifiers
  • wos:000181973100003
  • pmid:12635132
  • scopus:0041379477
ISSN
0022-3417
DOI
10.1002/path.1322
language
English
LU publication?
yes
id
6d94fbc8-b969-40d8-af6f-9723532fc8d0 (old id 315158)
date added to LUP
2007-09-16 10:40:01
date last changed
2018-11-21 20:07:11
@article{6d94fbc8-b969-40d8-af6f-9723532fc8d0,
  abstract     = {Unexpected outcomes in breast cancer demand a refinement of prognostic criteria. This study therefore investigated the prognostic relevance of cyclin expression in a cohort of 332 T1-T2 NO infiltrating ductal carcinomas with long-term follow-up (median 99 months). By univariate analysis, tumour size, histopathological grade, hormone receptor content, cyclin E, cyclin B, and the Ki-S5 (Ki-67) index significantly predicted disease-specific and metastasis-free survival. Cyclin A did not achieve statistical significance. In a multivariate analysis, both cyclin E [relative risk (RR) 2.01, p = 0.021] and cyclin B (RR 1.85, p = 0.033) were selected as independent prognosticators of metastasis-free survival when the Ki-67 index was omitted, but (only cyclin E expression was associated with disease-specific survival (RR 2.56, p = 0.006). When Ki-67 was included as a covariate, cyclin E lost its significance with respect to disease-specific survival but remained significant for metastasis-free survival. In an analogous analysis including Ki-67, the number of concurrently overexpressed cyclins did not attain statistical significance regarding disease-specific survival but was selected as the leading predictor of metastatic disease. It is concluded that combined overexpression of cyclins may imply genetic instability enhancing metastatic potential, but that survival ultimately depends on the proliferative activity of tumour cells. Copyright (C) 2003 John Wiley Sons, Ltd.},
  author       = {Kuhling, H and Alm, Per and Olsson, Håkan and Fernö, Mårten and Baldetorp, Bo and Parwaresch, R and Rudolph, P},
  issn         = {0022-3417},
  keyword      = {prognosis,breast cancer,immunohistochemistry,proliferation,Ki-S5,cyclin B,cyclin E,cyclin A,multivariate study},
  language     = {eng},
  number       = {4},
  pages        = {424--431},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Pathology},
  title        = {Expression of cyclins E, A, and B, and prognosis in lymph node-negative breast cancer},
  url          = {http://dx.doi.org/10.1002/path.1322},
  volume       = {199},
  year         = {2003},
}