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The associations between red cell distribution width and plasma proteins in a general population

Pan, Jingxue LU ; Borné, Yan LU ; Orho-Melander, Marju LU ; Nilsson, Jan LU ; Melander, Olle LU orcid and Engström, Gunnar LU (2021) In Clinical Proteomics 18(1).
Abstract

Background: High red cell distribution width (RDW) has been increasingly recognized as a risk factor for cardiovascular diseases (CVDs), but the underlying mechanisms remain unknown. Our aim was to explore the associations between RDW and plasma proteins implicated in the pathogenesis of CVD using a targeted proteomics panel. Methods: RDW and 88 plasma proteins were measured in a population-based cohort study (n = 4726), Malmö Diet and Cancer-Cardiovascular Cohort (MDC-CC). A random 2/3 of the cohort was used as discovery sample and remaining 1/3 was used for replication. Multiple linear regression was used to assess the associations between RDW and plasma proteins, with adjustments for age, sex, and other potential confounders.... (More)

Background: High red cell distribution width (RDW) has been increasingly recognized as a risk factor for cardiovascular diseases (CVDs), but the underlying mechanisms remain unknown. Our aim was to explore the associations between RDW and plasma proteins implicated in the pathogenesis of CVD using a targeted proteomics panel. Methods: RDW and 88 plasma proteins were measured in a population-based cohort study (n = 4726), Malmö Diet and Cancer-Cardiovascular Cohort (MDC-CC). A random 2/3 of the cohort was used as discovery sample and remaining 1/3 was used for replication. Multiple linear regression was used to assess the associations between RDW and plasma proteins, with adjustments for age, sex, and other potential confounders. Proteins with Bonferroni-corrected significant associations with RDW in the discovery sub-cohort were validated in the replication cohort. Results: Thirteen of 88 plasma proteins had significant associations with RDW in the discovery sample, after multivariate adjustments. Eleven of them were also significant in the replication sample, including SIR2-like protein 2 (SIRT2), stem cell factor (SCF, inversely), melusin (ITGB1BP2), growth differentiation factor-15 (GDF-15), matrix metalloproteinase-7 (MMP-7), hepatocyte growth factor (HGF), chitinase-3-like protein 1 (CHI3L1), interleukin-8 (IL-8), CD40 ligand (CD40-L), urokinase plasminogen activator surface receptor (U-PAR) and matrix metalloproteinase-3 (MMP-3). Conclusions: Several proteins from this targeted proteomics panel were associated with RDW in this cohort. These proteins could potentially be linked to the increased cardiovascular risk in individuals with high RDW.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiovascular panel, Plasma proteomics, Population-based, Red cell distribution width
in
Clinical Proteomics
volume
18
issue
1
article number
12
publisher
Humana Press
external identifiers
  • pmid:33781199
  • scopus:85103591427
ISSN
1542-6416
DOI
10.1186/s12014-021-09319-9
language
English
LU publication?
yes
id
6f47211a-1097-42aa-9bf6-45fece2a204b
date added to LUP
2021-04-12 07:13:47
date last changed
2025-01-26 08:54:06
@article{6f47211a-1097-42aa-9bf6-45fece2a204b,
  abstract     = {{<p>Background: High red cell distribution width (RDW) has been increasingly recognized as a risk factor for cardiovascular diseases (CVDs), but the underlying mechanisms remain unknown. Our aim was to explore the associations between RDW and plasma proteins implicated in the pathogenesis of CVD using a targeted proteomics panel. Methods: RDW and 88 plasma proteins were measured in a population-based cohort study (n = 4726), Malmö Diet and Cancer-Cardiovascular Cohort (MDC-CC). A random 2/3 of the cohort was used as discovery sample and remaining 1/3 was used for replication. Multiple linear regression was used to assess the associations between RDW and plasma proteins, with adjustments for age, sex, and other potential confounders. Proteins with Bonferroni-corrected significant associations with RDW in the discovery sub-cohort were validated in the replication cohort. Results: Thirteen of 88 plasma proteins had significant associations with RDW in the discovery sample, after multivariate adjustments. Eleven of them were also significant in the replication sample, including SIR2-like protein 2 (SIRT2), stem cell factor (SCF, inversely), melusin (ITGB1BP2), growth differentiation factor-15 (GDF-15), matrix metalloproteinase-7 (MMP-7), hepatocyte growth factor (HGF), chitinase-3-like protein 1 (CHI3L1), interleukin-8 (IL-8), CD40 ligand (CD40-L), urokinase plasminogen activator surface receptor (U-PAR) and matrix metalloproteinase-3 (MMP-3). Conclusions: Several proteins from this targeted proteomics panel were associated with RDW in this cohort. These proteins could potentially be linked to the increased cardiovascular risk in individuals with high RDW.</p>}},
  author       = {{Pan, Jingxue and Borné, Yan and Orho-Melander, Marju and Nilsson, Jan and Melander, Olle and Engström, Gunnar}},
  issn         = {{1542-6416}},
  keywords     = {{Cardiovascular panel; Plasma proteomics; Population-based; Red cell distribution width}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Humana Press}},
  series       = {{Clinical Proteomics}},
  title        = {{The associations between red cell distribution width and plasma proteins in a general population}},
  url          = {{http://dx.doi.org/10.1186/s12014-021-09319-9}},
  doi          = {{10.1186/s12014-021-09319-9}},
  volume       = {{18}},
  year         = {{2021}},
}