Nerve regeneration enhancement by tourniquet
Widerberg, Annika LU ; Lundborg, Göran LU and Dahlin, Lars LU
(2001)
In Journal of Hand Surgery (British Volume)
26(4).
p.347-351
- Abstract
- The use of tourniquet compression as a non-invasive method to enhance axonal regeneration was assessed in the rat sciatic nerve. One hind limb of the rat was subjected to compression by a tourniquet set at 300 mmHg for 30 or 120 min followed by bilateral test crush lesions performed either directly or after a conditioning interval of 3 or 6 days, with the non-compressed side serving as a control. Axonal regeneration distances were evaluated after 3 days by the pinch reflex test. We found that compression caused an increased outgrowth length of sensory axons compared to the controls. The effect was most obvious after 120 min of compression with a conditioning interval of 6 days. Tourniquet compression has a conditioning lesion effect on... (More)
- The use of tourniquet compression as a non-invasive method to enhance axonal regeneration was assessed in the rat sciatic nerve. One hind limb of the rat was subjected to compression by a tourniquet set at 300 mmHg for 30 or 120 min followed by bilateral test crush lesions performed either directly or after a conditioning interval of 3 or 6 days, with the non-compressed side serving as a control. Axonal regeneration distances were evaluated after 3 days by the pinch reflex test. We found that compression caused an increased outgrowth length of sensory axons compared to the controls. The effect was most obvious after 120 min of compression with a conditioning interval of 6 days. Tourniquet compression has a conditioning lesion effect on peripheral nerve and may enhance nerve regeneration. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121741
- author
- Widerberg, Annika
LU
; Lundborg, Göran
LU
and Dahlin, Lars
LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Hand Surgery (British Volume)
- volume
- 26
- issue
- 4
- pages
- 347 - 351
- publisher
- SAGE Publications
- external identifiers
-
- pmid:11469837
- scopus:0034877459
- ISSN
- 0266-7681
- DOI
- 10.1054/jhsb.2001.0599
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hand Surgery Research Group (013241910), Reconstructive Surgery (013240300)
- id
- 6ffa7fa1-83ce-423f-b6eb-dacd5be9023b (old id 1121741)
- date added to LUP
- 2016-04-01 16:45:14
- date last changed
- 2022-04-23 00:17:23
@article{6ffa7fa1-83ce-423f-b6eb-dacd5be9023b,
abstract = {{The use of tourniquet compression as a non-invasive method to enhance axonal regeneration was assessed in the rat sciatic nerve. One hind limb of the rat was subjected to compression by a tourniquet set at 300 mmHg for 30 or 120 min followed by bilateral test crush lesions performed either directly or after a conditioning interval of 3 or 6 days, with the non-compressed side serving as a control. Axonal regeneration distances were evaluated after 3 days by the pinch reflex test. We found that compression caused an increased outgrowth length of sensory axons compared to the controls. The effect was most obvious after 120 min of compression with a conditioning interval of 6 days. Tourniquet compression has a conditioning lesion effect on peripheral nerve and may enhance nerve regeneration.}},
author = {{Widerberg, Annika and Lundborg, Göran and Dahlin, Lars}},
issn = {{0266-7681}},
language = {{eng}},
number = {{4}},
pages = {{347--351}},
publisher = {{SAGE Publications}},
series = {{Journal of Hand Surgery (British Volume)}},
title = {{Nerve regeneration enhancement by tourniquet}},
url = {{http://dx.doi.org/10.1054/jhsb.2001.0599}},
doi = {{10.1054/jhsb.2001.0599}},
volume = {{26}},
year = {{2001}},
}