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Survival in ovarian cancer patients by histology and family history

Ji, Jianguang LU orcid ; Forsti, Asta LU ; Sundquist, Jan LU ; Lenner, Per and Hemminki, Kari LU (2008) In Acta Oncologica 47(6). p.1133-1139
Abstract

Introduction. Earlier studies suggest that histology has no prognostic significance in patients with invasive ovarian tumors. Studies about the effect of family history on survival have given conflicting results, which we try to clarify in this study. As an additional question, we examined whether family members share survival experience. Methods. We used the nation-wide Swedish Family-Cancer Database to estimate hazard ratios (HRs) for cause-specific and overall survival in ovarian cancer patients by histology and family history. HRs show the probability of death in the study group compared to the reference group. Results. A total of 6 049 ovarian cancer patients with specific histologies were retrieved from our Database from years... (More)

Introduction. Earlier studies suggest that histology has no prognostic significance in patients with invasive ovarian tumors. Studies about the effect of family history on survival have given conflicting results, which we try to clarify in this study. As an additional question, we examined whether family members share survival experience. Methods. We used the nation-wide Swedish Family-Cancer Database to estimate hazard ratios (HRs) for cause-specific and overall survival in ovarian cancer patients by histology and family history. HRs show the probability of death in the study group compared to the reference group. Results. A total of 6 049 ovarian cancer patients with specific histologies were retrieved from our Database from years 1993 to 1999. Compared to women with epithelial ovarian cancer, women with borderline epithelial tumors had the best survival (HR 0.02 and 0.14 for cause-specific and overall survival). Good survival was also noted for patients with sex cord-stromal tumors and germ cell tumors. Among specific subtypes of epithelial ovarian cancers, good survival was noted for women with clear cell and endometrioid carcinomas and mucinous cystadenocarcinoma. The study covered 80 mother-daughter pairs with a family history. Patients with a family history had a poorer survival than sporadic cases in both maternal and offspring generations. When the survival was analyzed according to the probands' length of survival, there was a non-significant concordance of prognosis. Conclusion. Our data showed that histology and family history are prognostic factors for ovarian tumors. Patients with a family history had a more aggressive course than the sporadic cases.

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type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
47
issue
6
pages
7 pages
publisher
Taylor & Francis
external identifiers
  • pmid:18607880
  • scopus:51149108542
ISSN
0284-186X
DOI
10.1080/02841860701784544
language
English
LU publication?
no
id
706018af-779a-464d-a6c2-e74cb4df7b89
date added to LUP
2019-01-30 10:40:42
date last changed
2024-06-11 03:34:22
@article{706018af-779a-464d-a6c2-e74cb4df7b89,
  abstract     = {{<p>Introduction. Earlier studies suggest that histology has no prognostic significance in patients with invasive ovarian tumors. Studies about the effect of family history on survival have given conflicting results, which we try to clarify in this study. As an additional question, we examined whether family members share survival experience. Methods. We used the nation-wide Swedish Family-Cancer Database to estimate hazard ratios (HRs) for cause-specific and overall survival in ovarian cancer patients by histology and family history. HRs show the probability of death in the study group compared to the reference group. Results. A total of 6 049 ovarian cancer patients with specific histologies were retrieved from our Database from years 1993 to 1999. Compared to women with epithelial ovarian cancer, women with borderline epithelial tumors had the best survival (HR 0.02 and 0.14 for cause-specific and overall survival). Good survival was also noted for patients with sex cord-stromal tumors and germ cell tumors. Among specific subtypes of epithelial ovarian cancers, good survival was noted for women with clear cell and endometrioid carcinomas and mucinous cystadenocarcinoma. The study covered 80 mother-daughter pairs with a family history. Patients with a family history had a poorer survival than sporadic cases in both maternal and offspring generations. When the survival was analyzed according to the probands' length of survival, there was a non-significant concordance of prognosis. Conclusion. Our data showed that histology and family history are prognostic factors for ovarian tumors. Patients with a family history had a more aggressive course than the sporadic cases.</p>}},
  author       = {{Ji, Jianguang and Forsti, Asta and Sundquist, Jan and Lenner, Per and Hemminki, Kari}},
  issn         = {{0284-186X}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{6}},
  pages        = {{1133--1139}},
  publisher    = {{Taylor & Francis}},
  series       = {{Acta Oncologica}},
  title        = {{Survival in ovarian cancer patients by histology and family history}},
  url          = {{http://dx.doi.org/10.1080/02841860701784544}},
  doi          = {{10.1080/02841860701784544}},
  volume       = {{47}},
  year         = {{2008}},
}