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The Other Side of SARS-CoV-2 Infection : Neurological Sequelae in Patients

Alonso-Bellido, Isabel M. ; Bachiller, Sara LU ; Vázquez, Guillermo ; Cruz-Hernández, Luis ; Martínez, Emilio ; Ruiz-Mateos, Ezequiel ; Deierborg, Tomas LU ; Venero, José L. ; Real, Luis M. and Ruiz, Rocío (2021) In Frontiers in Aging Neuroscience 13.
Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease 2019 (COVID-19). Because it affects the respiratory system, common symptoms are cough and breathing difficulties with fever and fatigue. Also, some cases progress to acute respiratory distress syndrome (ARDS). The acute phase of COVID-19 has been also related to nervous system symptoms, including loss of taste and smell as well as encephalitis and cerebrovascular disorders. However, it remains unclear if neurological complications are due to the direct viral infection of the nervous system, or they appear as a consequence of the immune reaction against the virus in patients who presented pre-existing deficits or had a... (More)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease 2019 (COVID-19). Because it affects the respiratory system, common symptoms are cough and breathing difficulties with fever and fatigue. Also, some cases progress to acute respiratory distress syndrome (ARDS). The acute phase of COVID-19 has been also related to nervous system symptoms, including loss of taste and smell as well as encephalitis and cerebrovascular disorders. However, it remains unclear if neurological complications are due to the direct viral infection of the nervous system, or they appear as a consequence of the immune reaction against the virus in patients who presented pre-existing deficits or had a certain detrimental immune response. Importantly, the medium and long-term consequences of the infection by SARS-CoV-2 in the nervous system remain at present unknown. This review article aims to give an overview of the current neurological symptoms associated with COVID-19, as well as attempting to provide an insight beyond the acute affectation.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
coronavirus, COVID-19, nervous system, neurological, SARS-CoV-2
in
Frontiers in Aging Neuroscience
volume
13
article number
632673
publisher
Frontiers Media S. A.
external identifiers
  • pmid:33889082
  • scopus:85104503508
ISSN
1663-4365
DOI
10.3389/fnagi.2021.632673
language
English
LU publication?
yes
id
717f36ea-924c-4f53-a195-b3588a2120e5
date added to LUP
2021-05-03 14:12:34
date last changed
2024-06-01 09:59:49
@article{717f36ea-924c-4f53-a195-b3588a2120e5,
  abstract     = {{<p>The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease 2019 (COVID-19). Because it affects the respiratory system, common symptoms are cough and breathing difficulties with fever and fatigue. Also, some cases progress to acute respiratory distress syndrome (ARDS). The acute phase of COVID-19 has been also related to nervous system symptoms, including loss of taste and smell as well as encephalitis and cerebrovascular disorders. However, it remains unclear if neurological complications are due to the direct viral infection of the nervous system, or they appear as a consequence of the immune reaction against the virus in patients who presented pre-existing deficits or had a certain detrimental immune response. Importantly, the medium and long-term consequences of the infection by SARS-CoV-2 in the nervous system remain at present unknown. This review article aims to give an overview of the current neurological symptoms associated with COVID-19, as well as attempting to provide an insight beyond the acute affectation.</p>}},
  author       = {{Alonso-Bellido, Isabel M. and Bachiller, Sara and Vázquez, Guillermo and Cruz-Hernández, Luis and Martínez, Emilio and Ruiz-Mateos, Ezequiel and Deierborg, Tomas and Venero, José L. and Real, Luis M. and Ruiz, Rocío}},
  issn         = {{1663-4365}},
  keywords     = {{coronavirus; COVID-19; nervous system; neurological; SARS-CoV-2}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Aging Neuroscience}},
  title        = {{The Other Side of SARS-CoV-2 Infection : Neurological Sequelae in Patients}},
  url          = {{http://dx.doi.org/10.3389/fnagi.2021.632673}},
  doi          = {{10.3389/fnagi.2021.632673}},
  volume       = {{13}},
  year         = {{2021}},
}