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Pregnancy-induced changes in serum concentrations of perfluoroalkyl substances and the influence of kidney function

Nielsen, Christel LU orcid ; Andersson Hall, Ulrika ; Lindh, Christian LU orcid ; Ekström, Ulf LU ; Xu, Yiyi LU ; Li, Ying ; Holmäng, Agneta and Jakobsson, Kristina (2020) In Environmental Health: A Global Access Science Source 19(1).
Abstract

Background: Epidemiological associations between maternal concentrations of perfluoroalkyl substances (PFAS) and birth weight are inconsistent. There is concern that studies based on samples collected in late pregnancy may be confounded by kidney function but studies of the relation between pregnancy-induced changes in PFAS and kidney function are lacking. Our aims were to investigate changes in serum concentrations of perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) from early to late pregnancy and to explore relations to changes in glomerular filtration rate (GFR) and glomerular pore size. Methods: We conducted the study in a cohort of 73 pregnancies... (More)

Background: Epidemiological associations between maternal concentrations of perfluoroalkyl substances (PFAS) and birth weight are inconsistent. There is concern that studies based on samples collected in late pregnancy may be confounded by kidney function but studies of the relation between pregnancy-induced changes in PFAS and kidney function are lacking. Our aims were to investigate changes in serum concentrations of perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) from early to late pregnancy and to explore relations to changes in glomerular filtration rate (GFR) and glomerular pore size. Methods: We conducted the study in a cohort of 73 pregnancies of normal-weight Swedish women without gestational diabetes and preeclampsia, enrolled 2009-2014. Blood was collected in median weeks 11 and 36, respectively, and analysed PFAS using liquid chromatography-tandem-mass-spectrometry. We estimated GFR based on creatinine and cystatin C and used the ratio eGFRcystatin C/eGFRcreatinine to indicate glomerular pore size. We used Wilcoxon signed-rank test to compare early and late measures and partial Spearman rank correlations to explore relations between changes in PFAS and kidney function. Results: Median concentrations of PFNA, PFOA and PFOS decreased by 15-21% but changes were uncorrelated to changes in kidney function (partial R = - 0.06-0.11). The observed increase in median PFHxS concentration of 69% was likely an artefact of systematic measurement error caused by coeluting endogenous inferences. Conclusions: Serum concentrations of PFNA, PFOA and PFOS decrease during pregnancy but the magnitudes of change are unrelated to parallel changes in eGFR and glomerular pore size, suggesting that changes in these indicators of kidney function are not important confounders in studies of PFAS and birth weight in pregnancies without gestational diabetes and preeclampsia.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Glomerular filtration rate, glomerular pore size, Perfluoroalkyl substances, Pregnancy
in
Environmental Health: A Global Access Science Source
volume
19
issue
1
article number
80
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85087716202
  • pmid:32641055
ISSN
1476-069X
DOI
10.1186/s12940-020-00626-6
language
English
LU publication?
yes
id
71ce6f01-d4f9-4d2d-b93f-343f69501fbd
date added to LUP
2020-07-22 08:28:47
date last changed
2024-03-20 13:09:21
@article{71ce6f01-d4f9-4d2d-b93f-343f69501fbd,
  abstract     = {{<p>Background: Epidemiological associations between maternal concentrations of perfluoroalkyl substances (PFAS) and birth weight are inconsistent. There is concern that studies based on samples collected in late pregnancy may be confounded by kidney function but studies of the relation between pregnancy-induced changes in PFAS and kidney function are lacking. Our aims were to investigate changes in serum concentrations of perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) from early to late pregnancy and to explore relations to changes in glomerular filtration rate (GFR) and glomerular pore size. Methods: We conducted the study in a cohort of 73 pregnancies of normal-weight Swedish women without gestational diabetes and preeclampsia, enrolled 2009-2014. Blood was collected in median weeks 11 and 36, respectively, and analysed PFAS using liquid chromatography-tandem-mass-spectrometry. We estimated GFR based on creatinine and cystatin C and used the ratio eGFRcystatin C/eGFRcreatinine to indicate glomerular pore size. We used Wilcoxon signed-rank test to compare early and late measures and partial Spearman rank correlations to explore relations between changes in PFAS and kidney function. Results: Median concentrations of PFNA, PFOA and PFOS decreased by 15-21% but changes were uncorrelated to changes in kidney function (partial R = - 0.06-0.11). The observed increase in median PFHxS concentration of 69% was likely an artefact of systematic measurement error caused by coeluting endogenous inferences. Conclusions: Serum concentrations of PFNA, PFOA and PFOS decrease during pregnancy but the magnitudes of change are unrelated to parallel changes in eGFR and glomerular pore size, suggesting that changes in these indicators of kidney function are not important confounders in studies of PFAS and birth weight in pregnancies without gestational diabetes and preeclampsia. </p>}},
  author       = {{Nielsen, Christel and Andersson Hall, Ulrika and Lindh, Christian and Ekström, Ulf and Xu, Yiyi and Li, Ying and Holmäng, Agneta and Jakobsson, Kristina}},
  issn         = {{1476-069X}},
  keywords     = {{Glomerular filtration rate, glomerular pore size; Perfluoroalkyl substances; Pregnancy}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Environmental Health: A Global Access Science Source}},
  title        = {{Pregnancy-induced changes in serum concentrations of perfluoroalkyl substances and the influence of kidney function}},
  url          = {{http://dx.doi.org/10.1186/s12940-020-00626-6}},
  doi          = {{10.1186/s12940-020-00626-6}},
  volume       = {{19}},
  year         = {{2020}},
}