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Investigating magnetically induced dynamics with x-ray photon correlation spectroscopy to enhance contrast in magnetomotive ultrasound imaging

Sala, S. LU ; Yu, S. LU ; Mousavi, A. ; Niga, P. ; Santesson, M. and Jansson, T. LU (2026) In Applied Physics Letters 128(8).
Abstract

A synchrotron-based experiment was carried out to demonstrate the potential of x-ray photon correlation spectroscopy (XPCS) to characterize collective dynamics driven by superparamagnetic iron oxide nanoparticles (SPIONs) during magnetomotive ultrasound (MMUS) imaging. MMUS is a developing diagnostic imaging technique that has the potential to enable more precise cancer staging than other clinically established diagnostic tools. It relies on SPIONs acting as a contrast agent while being stimulated by time-varying magnetic fields. The resulting dynamics are crucial to maximizing image contrast. We describe the design and execution of an XPCS experiment on phantoms mimicking human tissue during MMUS imaging. Quantitative analysis of the... (More)

A synchrotron-based experiment was carried out to demonstrate the potential of x-ray photon correlation spectroscopy (XPCS) to characterize collective dynamics driven by superparamagnetic iron oxide nanoparticles (SPIONs) during magnetomotive ultrasound (MMUS) imaging. MMUS is a developing diagnostic imaging technique that has the potential to enable more precise cancer staging than other clinically established diagnostic tools. It relies on SPIONs acting as a contrast agent while being stimulated by time-varying magnetic fields. The resulting dynamics are crucial to maximizing image contrast. We describe the design and execution of an XPCS experiment on phantoms mimicking human tissue during MMUS imaging. Quantitative analysis of the results reveals variations in the temporal correlation functions of the scattered intensity as a function of scattering vector and angle. Preliminary observations indicate that these variations might depend on experimental parameters such as the frequency and strength of the magnetic field and SPION type and concentration.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Applied Physics Letters
volume
128
issue
8
article number
083307
publisher
American Institute of Physics (AIP)
external identifiers
  • scopus:105031098474
ISSN
0003-6951
DOI
10.1063/5.0314713
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2026 Author(s).
id
720d05a3-7f48-4b9a-8e6e-8378156df08d
date added to LUP
2026-04-02 13:00:14
date last changed
2026-04-09 11:58:51
@article{720d05a3-7f48-4b9a-8e6e-8378156df08d,
  abstract     = {{<p>A synchrotron-based experiment was carried out to demonstrate the potential of x-ray photon correlation spectroscopy (XPCS) to characterize collective dynamics driven by superparamagnetic iron oxide nanoparticles (SPIONs) during magnetomotive ultrasound (MMUS) imaging. MMUS is a developing diagnostic imaging technique that has the potential to enable more precise cancer staging than other clinically established diagnostic tools. It relies on SPIONs acting as a contrast agent while being stimulated by time-varying magnetic fields. The resulting dynamics are crucial to maximizing image contrast. We describe the design and execution of an XPCS experiment on phantoms mimicking human tissue during MMUS imaging. Quantitative analysis of the results reveals variations in the temporal correlation functions of the scattered intensity as a function of scattering vector and angle. Preliminary observations indicate that these variations might depend on experimental parameters such as the frequency and strength of the magnetic field and SPION type and concentration.</p>}},
  author       = {{Sala, S. and Yu, S. and Mousavi, A. and Niga, P. and Santesson, M. and Jansson, T.}},
  issn         = {{0003-6951}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{8}},
  publisher    = {{American Institute of Physics (AIP)}},
  series       = {{Applied Physics Letters}},
  title        = {{Investigating magnetically induced dynamics with x-ray photon correlation spectroscopy to enhance contrast in magnetomotive ultrasound imaging}},
  url          = {{http://dx.doi.org/10.1063/5.0314713}},
  doi          = {{10.1063/5.0314713}},
  volume       = {{128}},
  year         = {{2026}},
}