Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Human proteome distribution atlas for tissue-specific plasma proteome dynamics

Malmström, Erik LU ; Malmström, Lars LU ; Hauri, Simon LU ; Mohanty, Tirthankar LU ; Scott, Aaron LU ; Karlsson, Christofer LU ; Gueto-Tettay, Carlos LU ; Åhrman, Emma LU ; Nozohoor, Shahab LU orcid and Tingstedt, Bobby LU , et al. (2025) In Cell p.1-13
Abstract

The plasma proteome is maintained by the influx and efflux of proteins from surrounding organs and cells. To quantify the extent to which different organs and cells impact the plasma proteome in healthy and diseased conditions, we developed a mass-spectrometry-based proteomics strategy to infer the tissue origin of proteins detected in human plasma. We first constructed an extensive human proteome atlas from 18 vascularized organs and the 8 most abundant cell types in blood. The atlas was interfaced with previous RNA and protein atlases to objectively define proteome-wide protein-organ associations to infer the origin and enable the reproducible quantification of organ-specific proteins in plasma. We demonstrate that the resource can... (More)

The plasma proteome is maintained by the influx and efflux of proteins from surrounding organs and cells. To quantify the extent to which different organs and cells impact the plasma proteome in healthy and diseased conditions, we developed a mass-spectrometry-based proteomics strategy to infer the tissue origin of proteins detected in human plasma. We first constructed an extensive human proteome atlas from 18 vascularized organs and the 8 most abundant cell types in blood. The atlas was interfaced with previous RNA and protein atlases to objectively define proteome-wide protein-organ associations to infer the origin and enable the reproducible quantification of organ-specific proteins in plasma. We demonstrate that the resource can determine disease-specific quantitative changes of organ-enriched protein panels in six separate patient cohorts, including sepsis, pancreatitis, and myocardial injury. The strategy can be extended to other diseases to advance our understanding of the processes contributing to plasma proteome dynamics.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Cell
pages
1 - 13
publisher
Cell Press
external identifiers
  • pmid:40203824
ISSN
1097-4172
DOI
10.1016/j.cell.2025.03.013
language
English
LU publication?
yes
additional info
Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved.
id
7223fc38-11ce-43ec-afd9-05f61b0b9a74
date added to LUP
2025-04-10 09:43:27
date last changed
2025-04-10 12:21:58
@article{7223fc38-11ce-43ec-afd9-05f61b0b9a74,
  abstract     = {{<p>The plasma proteome is maintained by the influx and efflux of proteins from surrounding organs and cells. To quantify the extent to which different organs and cells impact the plasma proteome in healthy and diseased conditions, we developed a mass-spectrometry-based proteomics strategy to infer the tissue origin of proteins detected in human plasma. We first constructed an extensive human proteome atlas from 18 vascularized organs and the 8 most abundant cell types in blood. The atlas was interfaced with previous RNA and protein atlases to objectively define proteome-wide protein-organ associations to infer the origin and enable the reproducible quantification of organ-specific proteins in plasma. We demonstrate that the resource can determine disease-specific quantitative changes of organ-enriched protein panels in six separate patient cohorts, including sepsis, pancreatitis, and myocardial injury. The strategy can be extended to other diseases to advance our understanding of the processes contributing to plasma proteome dynamics.</p>}},
  author       = {{Malmström, Erik and Malmström, Lars and Hauri, Simon and Mohanty, Tirthankar and Scott, Aaron and Karlsson, Christofer and Gueto-Tettay, Carlos and Åhrman, Emma and Nozohoor, Shahab and Tingstedt, Bobby and Regner, Sara and Elfving, Peter and Bjermer, Leif and Forsvall, Andreas and Doyle, Alexander and Magnusson, Mattias and Hedenfalk, Ingrid and Kannisto, Päivi and Brandt, Christian and Nilsson, Emma and Dahlin, Lars B and Malm, Johan and Linder, Adam and Niméus, Emma and Malmström, Johan}},
  issn         = {{1097-4172}},
  language     = {{eng}},
  month        = {{04}},
  pages        = {{1--13}},
  publisher    = {{Cell Press}},
  series       = {{Cell}},
  title        = {{Human proteome distribution atlas for tissue-specific plasma proteome dynamics}},
  url          = {{http://dx.doi.org/10.1016/j.cell.2025.03.013}},
  doi          = {{10.1016/j.cell.2025.03.013}},
  year         = {{2025}},
}