Cancer risk among patients hospitalized for Type 1 diabetes mellitus: a population-based cohort study in Sweden
Shu, Xiaochen LU ; Ji, Jianguang LU
; Li, Xinjun
LU
; Sundquist, Jan
LU
and Hemminki, Kari
LU
(2010)
In Diabetic Medicine
27(7).
p.791-797
- Abstract
- P>Aims Type 1 diabetes mellitus (T1DM) is an autoimmune disease with potential mechanistic links to immune-related cancers. We aimed at examining the overall and specific cancer risks among hospitalized T1DM patients from the national registers in Sweden. Methods A T1DM research cohort was created by identifying T1DM patients from the Hospital Discharge Register and linking them with the Cancer Registry. Standardized incidence ratios (SIRs) for subsequent cancers were calculated among patients with T1DM compared with those without T1DM. Results Two hundred and fifty-eight cases were ascertained with subsequent cancers during the follow-up duration from 1964 to 2006, with an increased overall SIR of 1.17 (95% CI 1.04-1.33) among 24 052... (More)
- P>Aims Type 1 diabetes mellitus (T1DM) is an autoimmune disease with potential mechanistic links to immune-related cancers. We aimed at examining the overall and specific cancer risks among hospitalized T1DM patients from the national registers in Sweden. Methods A T1DM research cohort was created by identifying T1DM patients from the Hospital Discharge Register and linking them with the Cancer Registry. Standardized incidence ratios (SIRs) for subsequent cancers were calculated among patients with T1DM compared with those without T1DM. Results Two hundred and fifty-eight cases were ascertained with subsequent cancers during the follow-up duration from 1964 to 2006, with an increased overall SIR of 1.17 (95% CI 1.04-1.33) among 24 052 T1DM patients identified at baseline. Significant excess was noted for gastric and skin (squamous cell carcinoma) cancers and for leukaemia. Increased risk of acute lymphatic leukaemia accounted for most of the variation of leukaemia risk (SIR = 5.31, 95% CI 3.32-8.05). Cancer risk varied with sex, age at first hospitalization and numbers of hospitalizations. The risk was higher in women compared with men and in those hospitalized for T1DM at age over 10 years compared with the younger patients. Higher risks were also found among those with more hospital visits. Conclusion By quantifying the variations of overall and site-specific cancer risks after T1DM, the current study provides novel associations between T1DM and subsequent cancers, the mechanisms of which remain to be established. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1629256
- author
- Shu, Xiaochen
LU
; Ji, Jianguang
LU
; Li, Xinjun
LU
; Sundquist, Jan
LU
and Hemminki, Kari
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- national registry, age at first hospitalization, cancer risk, diabetes mellitus, Type 1
- in
- Diabetic Medicine
- volume
- 27
- issue
- 7
- pages
- 791 - 797
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000279440600011
- scopus:77954249988
- pmid:20636960
- ISSN
- 1464-5491
- DOI
- 10.1111/j.1464-5491.2010.03011.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Psychiatry/Primary Care/Public Health (013240500), Family medicine, psychiatric epidemiology and migration (013240037), Family Medicine (013241010), Family medicine, cardiovascular epidemiology and lifestyle (013240038)
- id
- 723bf9d5-05a8-4ec8-893b-82458f1d23ab (old id 1629256)
- date added to LUP
- 2016-04-01 13:04:37
- date last changed
- 2022-04-21 19:34:28
@article{723bf9d5-05a8-4ec8-893b-82458f1d23ab,
abstract = {{P>Aims Type 1 diabetes mellitus (T1DM) is an autoimmune disease with potential mechanistic links to immune-related cancers. We aimed at examining the overall and specific cancer risks among hospitalized T1DM patients from the national registers in Sweden. Methods A T1DM research cohort was created by identifying T1DM patients from the Hospital Discharge Register and linking them with the Cancer Registry. Standardized incidence ratios (SIRs) for subsequent cancers were calculated among patients with T1DM compared with those without T1DM. Results Two hundred and fifty-eight cases were ascertained with subsequent cancers during the follow-up duration from 1964 to 2006, with an increased overall SIR of 1.17 (95% CI 1.04-1.33) among 24 052 T1DM patients identified at baseline. Significant excess was noted for gastric and skin (squamous cell carcinoma) cancers and for leukaemia. Increased risk of acute lymphatic leukaemia accounted for most of the variation of leukaemia risk (SIR = 5.31, 95% CI 3.32-8.05). Cancer risk varied with sex, age at first hospitalization and numbers of hospitalizations. The risk was higher in women compared with men and in those hospitalized for T1DM at age over 10 years compared with the younger patients. Higher risks were also found among those with more hospital visits. Conclusion By quantifying the variations of overall and site-specific cancer risks after T1DM, the current study provides novel associations between T1DM and subsequent cancers, the mechanisms of which remain to be established.}},
author = {{Shu, Xiaochen and Ji, Jianguang and Li, Xinjun and Sundquist, Jan and Hemminki, Kari}},
issn = {{1464-5491}},
keywords = {{national registry; age at first hospitalization; cancer risk; diabetes mellitus; Type 1}},
language = {{eng}},
number = {{7}},
pages = {{791--797}},
publisher = {{Wiley-Blackwell}},
series = {{Diabetic Medicine}},
title = {{Cancer risk among patients hospitalized for Type 1 diabetes mellitus: a population-based cohort study in Sweden}},
url = {{http://dx.doi.org/10.1111/j.1464-5491.2010.03011.x}},
doi = {{10.1111/j.1464-5491.2010.03011.x}},
volume = {{27}},
year = {{2010}},
}