The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.
(2015) In PLoS ONE 10(8).- Abstract
- High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7840581
- author
- Fritz, Helena LU ; Gustafsson, Anna LU ; Ljungberg, Börje ; Ceder, Yvonne LU ; Axelson, Håkan LU and Dahlbäck, Björn LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 10
- issue
- 8
- article number
- e0135991
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:26287733
- wos:000360018600095
- scopus:84942474892
- pmid:26287733
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0135991
- language
- English
- LU publication?
- yes
- id
- 73026e14-a2f7-4b5d-a1c8-7fc126ec708c (old id 7840581)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26287733?dopt=Abstract
- date added to LUP
- 2016-04-01 13:54:04
- date last changed
- 2022-05-19 02:20:01
@article{73026e14-a2f7-4b5d-a1c8-7fc126ec708c, abstract = {{High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.}}, author = {{Fritz, Helena and Gustafsson, Anna and Ljungberg, Börje and Ceder, Yvonne and Axelson, Håkan and Dahlbäck, Björn}}, issn = {{1932-6203}}, language = {{eng}}, number = {{8}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.}}, url = {{https://lup.lub.lu.se/search/files/3657486/8603288}}, doi = {{10.1371/journal.pone.0135991}}, volume = {{10}}, year = {{2015}}, }