Body mass index in young school age children in relation to organochlorine compounds in early life: a prospective study.
(2014) In International Journal of Obesity 38(7). p.919-925- Abstract
- Objective:To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in five to nine-year-old children.Methods:Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland) and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and... (More)
- Objective:To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in five to nine-year-old children.Methods:Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland) and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age- and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis.Results:No clear associations between pregnancy CB-153 and p,p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10) kg m(-2), respectively). For postnatal CB-153 and p,p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) kg m(-2), respectively.Conclusions:This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p,p'-DDE and CB-153 and BMI at the age of five to nine years.International Journal of Obesity accepted article peview online, 10 April 2014; doi:10.1038/ijo.2014.58. (Less)
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https://lup.lub.lu.se/record/4430494
- author
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Obesity
- volume
- 38
- issue
- 7
- pages
- 919 - 925
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:24718355
- wos:000339197000004
- scopus:84904042649
- pmid:24718355
- ISSN
- 1476-5497
- DOI
- 10.1038/ijo.2014.58
- language
- English
- LU publication?
- yes
- id
- 730d3525-3dc6-4aa9-8fc6-52f61283fa53 (old id 4430494)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24718355?dopt=Abstract
- date added to LUP
- 2016-04-01 09:51:41
- date last changed
- 2022-03-11 23:46:02
@article{730d3525-3dc6-4aa9-8fc6-52f61283fa53, abstract = {{Objective:To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in five to nine-year-old children.Methods:Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland) and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age- and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis.Results:No clear associations between pregnancy CB-153 and p,p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10) kg m(-2), respectively). For postnatal CB-153 and p,p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) kg m(-2), respectively.Conclusions:This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p,p'-DDE and CB-153 and BMI at the age of five to nine years.International Journal of Obesity accepted article peview online, 10 April 2014; doi:10.1038/ijo.2014.58.}}, author = {{Høyer, B B and Ramlau-Hansen, C H and Henriksen, T B and Pedersen, H S and Góralczyk, K and Zviezdai, V and Jönsson, Bo A and Heederik, D and Lenters, V and Vermeulen, R and Peter Bonde, J and Toft, G}}, issn = {{1476-5497}}, language = {{eng}}, number = {{7}}, pages = {{919--925}}, publisher = {{Nature Publishing Group}}, series = {{International Journal of Obesity}}, title = {{Body mass index in young school age children in relation to organochlorine compounds in early life: a prospective study.}}, url = {{http://dx.doi.org/10.1038/ijo.2014.58}}, doi = {{10.1038/ijo.2014.58}}, volume = {{38}}, year = {{2014}}, }