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Body mass index in young school age children in relation to organochlorine compounds in early life: a prospective study.

Høyer, B B ; Ramlau-Hansen, C H ; Henriksen, T B ; Pedersen, H S ; Góralczyk, K ; Zviezdai, V ; Jönsson, Bo A LU ; Heederik, D ; Lenters, V and Vermeulen, R , et al. (2014) In International Journal of Obesity 38(7). p.919-925
Abstract
Objective:To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in five to nine-year-old children.Methods:Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland) and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and... (More)
Objective:To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in five to nine-year-old children.Methods:Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland) and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age- and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis.Results:No clear associations between pregnancy CB-153 and p,p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10) kg m(-2), respectively). For postnatal CB-153 and p,p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) kg m(-2), respectively.Conclusions:This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p,p'-DDE and CB-153 and BMI at the age of five to nine years.International Journal of Obesity accepted article peview online, 10 April 2014; doi:10.1038/ijo.2014.58. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Obesity
volume
38
issue
7
pages
919 - 925
publisher
Nature Publishing Group
external identifiers
  • pmid:24718355
  • wos:000339197000004
  • scopus:84904042649
  • pmid:24718355
ISSN
1476-5497
DOI
10.1038/ijo.2014.58
language
English
LU publication?
yes
id
730d3525-3dc6-4aa9-8fc6-52f61283fa53 (old id 4430494)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24718355?dopt=Abstract
date added to LUP
2016-04-01 09:51:41
date last changed
2022-03-11 23:46:02
@article{730d3525-3dc6-4aa9-8fc6-52f61283fa53,
  abstract     = {{Objective:To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in five to nine-year-old children.Methods:Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland) and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age- and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis.Results:No clear associations between pregnancy CB-153 and p,p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10) kg m(-2), respectively). For postnatal CB-153 and p,p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) kg m(-2), respectively.Conclusions:This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p,p'-DDE and CB-153 and BMI at the age of five to nine years.International Journal of Obesity accepted article peview online, 10 April 2014; doi:10.1038/ijo.2014.58.}},
  author       = {{Høyer, B B and Ramlau-Hansen, C H and Henriksen, T B and Pedersen, H S and Góralczyk, K and Zviezdai, V and Jönsson, Bo A and Heederik, D and Lenters, V and Vermeulen, R and Peter Bonde, J and Toft, G}},
  issn         = {{1476-5497}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{919--925}},
  publisher    = {{Nature Publishing Group}},
  series       = {{International Journal of Obesity}},
  title        = {{Body mass index in young school age children in relation to organochlorine compounds in early life: a prospective study.}},
  url          = {{http://dx.doi.org/10.1038/ijo.2014.58}},
  doi          = {{10.1038/ijo.2014.58}},
  volume       = {{38}},
  year         = {{2014}},
}