Spatially varying regularization based on spectrally resolved fluorescence emission in fluorescence molecular tomography
(2007) In Optics Express 15(21). p.13574-13584- Abstract
- Fluorescence molecular tomography suffers from being mathematically ill-conditioned resulting in non-unique solutions to the reconstruction problem. In an attempt to reduce the number of possible solutions in the underdetermined system of equations in the reconstruction, we present a method to retrieve a spatially varying regularization map outlining the feasible inclusion position. This approach can be made very simple by including a few multispectral recordings from only one source position. The results retrieved through tissue phantom experiments imply that initial reconstructions with spatially varying priors reduces artifacts and show slightly more accurate reconstruction results compared to reconstructions using no priors.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/968806
- author
- Axelsson, Johan LU ; Svensson, Jenny LU and Andersson-Engels, Stefan LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Optics Express
- volume
- 15
- issue
- 21
- pages
- 13574 - 13584
- publisher
- Optical Society of America
- external identifiers
-
- wos:000251223100010
- scopus:35348964199
- ISSN
- 1094-4087
- language
- English
- LU publication?
- yes
- id
- 7310be3d-0817-4b55-b7e8-c7190612dd70 (old id 968806)
- alternative location
- http://www.opticsinfobase.org/abstract.cfm?URI=oe-15-21-13574
- date added to LUP
- 2016-04-01 17:14:38
- date last changed
- 2022-01-29 01:22:34
@article{7310be3d-0817-4b55-b7e8-c7190612dd70, abstract = {{Fluorescence molecular tomography suffers from being mathematically ill-conditioned resulting in non-unique solutions to the reconstruction problem. In an attempt to reduce the number of possible solutions in the underdetermined system of equations in the reconstruction, we present a method to retrieve a spatially varying regularization map outlining the feasible inclusion position. This approach can be made very simple by including a few multispectral recordings from only one source position. The results retrieved through tissue phantom experiments imply that initial reconstructions with spatially varying priors reduces artifacts and show slightly more accurate reconstruction results compared to reconstructions using no priors.}}, author = {{Axelsson, Johan and Svensson, Jenny and Andersson-Engels, Stefan}}, issn = {{1094-4087}}, language = {{eng}}, number = {{21}}, pages = {{13574--13584}}, publisher = {{Optical Society of America}}, series = {{Optics Express}}, title = {{Spatially varying regularization based on spectrally resolved fluorescence emission in fluorescence molecular tomography}}, url = {{https://lup.lub.lu.se/search/files/4918226/2368876.pdf}}, volume = {{15}}, year = {{2007}}, }