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Integrating disease knowledge and technology to deliver protein targets and biomarkers into drug discovery projects

Fehniger, Thomas E. ; Laurell, Thomas LU and Marko-Varga, György LU (2005) In Drug Discovery Today: Technologies 2(4). p.345-351
Abstract
Biomarker discovery is dependent upon two disciplines: the field of clinical bioanalysis linked to disease aetiology and the application of high level technology platforms for identifying proteins/peptides in complex samples. However, diagnostic biomarker measurements require certain definitions of context that can only be achieved by combining protein science with clinical science. The evaluation of biomarkers requires careful attention to match (1) a specific biological question with (2) the appropriate clinical sample and (3) high resolution technology systems which link protein identities to clinical informatics.
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Drug Discovery Today: Technologies
volume
2
issue
4
pages
345 - 351
publisher
Elsevier
external identifiers
  • scopus:30944439263
ISSN
1740-6749
DOI
10.1016/j.ddtec.2005.11.005
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Biomedical Engineering (011200011), Analytical Chemistry (S/LTH) (011001004)
id
2fbc1004-d382-4dc5-b40d-63e755760185 (old id 744168)
date added to LUP
2016-04-04 09:06:20
date last changed
2020-01-12 20:40:58
@article{2fbc1004-d382-4dc5-b40d-63e755760185,
  abstract     = {Biomarker discovery is dependent upon two disciplines: the field of clinical bioanalysis linked to disease aetiology and the application of high level technology platforms for identifying proteins/peptides in complex samples. However, diagnostic biomarker measurements require certain definitions of context that can only be achieved by combining protein science with clinical science. The evaluation of biomarkers requires careful attention to match (1) a specific biological question with (2) the appropriate clinical sample and (3) high resolution technology systems which link protein identities to clinical informatics.},
  author       = {Fehniger, Thomas E. and Laurell, Thomas and Marko-Varga, György},
  issn         = {1740-6749},
  language     = {eng},
  number       = {4},
  pages        = {345--351},
  publisher    = {Elsevier},
  series       = {Drug Discovery Today: Technologies},
  title        = {Integrating disease knowledge and technology to deliver protein targets and biomarkers into drug discovery projects},
  url          = {http://dx.doi.org/10.1016/j.ddtec.2005.11.005},
  doi          = {10.1016/j.ddtec.2005.11.005},
  volume       = {2},
  year         = {2005},
}