Advanced

The water-perfusable tissue fraction of colorectal cancer metastases is increased by the selective PDGF-receptor inhibitor imatinib but not the IL-1 receptor antagonist anakinra, a study using serial dynamic 15O-water PET.

Lubberink, Mark; Golla, Sandeep S V; Jonasson, My; Rubin, Kristofer LU ; Glimelius, Bengt; Sörensen, Jens and Nygren, Peter (2015) In Journal of Nuclear Medicine 56(8). p.1144-1149
Abstract
High interstitial fluid pressure (IFP) in colorectal cancer metastases may decrease the uptake and, thus, the effects of anti-tumor drugs. Imatinib, a selective inhibitor of PDGF receptors, and anakinra, an interleukin-1 receptor antagonist, respectively, increase drug uptake and/or decrease IFP in preclinical models of carcinoma. Drug-induced decrease in IFP in human metastases has not been objectively shown, but should be reflected by an increase in water-perfusable tissue fraction (PTF) or tumor blood flow (TBF) using [(15)O]water PET/CT and kinetic modelling. Hence, the aim of this study was to assess the effects of imatinib and anakinra on PTF and TBF in colorectal cancer metastases in patients.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nuclear Medicine
volume
56
issue
8
pages
1144 - 1149
publisher
Society of Nuclear Medicine
external identifiers
  • pmid:26069310
  • wos:000359178300021
  • scopus:84938846080
ISSN
0161-5505
DOI
10.2967/jnumed.114.151894
language
English
LU publication?
yes
id
6d4ba035-04a0-49da-98d8-b8cc381cdb9a (old id 7486599)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26069310?dopt=Abstract
date added to LUP
2015-07-08 12:12:49
date last changed
2017-09-03 03:27:08
@article{6d4ba035-04a0-49da-98d8-b8cc381cdb9a,
  abstract     = {High interstitial fluid pressure (IFP) in colorectal cancer metastases may decrease the uptake and, thus, the effects of anti-tumor drugs. Imatinib, a selective inhibitor of PDGF receptors, and anakinra, an interleukin-1 receptor antagonist, respectively, increase drug uptake and/or decrease IFP in preclinical models of carcinoma. Drug-induced decrease in IFP in human metastases has not been objectively shown, but should be reflected by an increase in water-perfusable tissue fraction (PTF) or tumor blood flow (TBF) using [(15)O]water PET/CT and kinetic modelling. Hence, the aim of this study was to assess the effects of imatinib and anakinra on PTF and TBF in colorectal cancer metastases in patients.},
  author       = {Lubberink, Mark and Golla, Sandeep S V and Jonasson, My and Rubin, Kristofer and Glimelius, Bengt and Sörensen, Jens and Nygren, Peter},
  issn         = {0161-5505},
  language     = {eng},
  number       = {8},
  pages        = {1144--1149},
  publisher    = {Society of Nuclear Medicine},
  series       = {Journal of Nuclear Medicine},
  title        = {The water-perfusable tissue fraction of colorectal cancer metastases is increased by the selective PDGF-receptor inhibitor imatinib but not the IL-1 receptor antagonist anakinra, a study using serial dynamic 15O-water PET.},
  url          = {http://dx.doi.org/10.2967/jnumed.114.151894},
  volume       = {56},
  year         = {2015},
}