The water-perfusable tissue fraction of colorectal cancer metastases is increased by the selective PDGF-receptor inhibitor imatinib but not the IL-1 receptor antagonist anakinra, a study using serial dynamic 15O-water PET.
(2015) In Journal of Nuclear Medicine 56(8). p.1144-1149- Abstract
- High interstitial fluid pressure (IFP) in colorectal cancer metastases may decrease the uptake and, thus, the effects of anti-tumor drugs. Imatinib, a selective inhibitor of PDGF receptors, and anakinra, an interleukin-1 receptor antagonist, respectively, increase drug uptake and/or decrease IFP in preclinical models of carcinoma. Drug-induced decrease in IFP in human metastases has not been objectively shown, but should be reflected by an increase in water-perfusable tissue fraction (PTF) or tumor blood flow (TBF) using [(15)O]water PET/CT and kinetic modelling. Hence, the aim of this study was to assess the effects of imatinib and anakinra on PTF and TBF in colorectal cancer metastases in patients.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7486599
- author
- Lubberink, Mark ; Golla, Sandeep S V ; Jonasson, My ; Rubin, Kristofer LU ; Glimelius, Bengt ; Sörensen, Jens and Nygren, Peter
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Nuclear Medicine
- volume
- 56
- issue
- 8
- pages
- 1144 - 1149
- publisher
- Society of Nuclear Medicine
- external identifiers
-
- pmid:26069310
- wos:000359178300021
- scopus:84938846080
- pmid:26069310
- ISSN
- 0161-5505
- DOI
- 10.2967/jnumed.114.151894
- language
- English
- LU publication?
- yes
- id
- 6d4ba035-04a0-49da-98d8-b8cc381cdb9a (old id 7486599)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26069310?dopt=Abstract
- date added to LUP
- 2016-04-01 10:52:13
- date last changed
- 2022-02-17 22:07:27
@article{6d4ba035-04a0-49da-98d8-b8cc381cdb9a, abstract = {{High interstitial fluid pressure (IFP) in colorectal cancer metastases may decrease the uptake and, thus, the effects of anti-tumor drugs. Imatinib, a selective inhibitor of PDGF receptors, and anakinra, an interleukin-1 receptor antagonist, respectively, increase drug uptake and/or decrease IFP in preclinical models of carcinoma. Drug-induced decrease in IFP in human metastases has not been objectively shown, but should be reflected by an increase in water-perfusable tissue fraction (PTF) or tumor blood flow (TBF) using [(15)O]water PET/CT and kinetic modelling. Hence, the aim of this study was to assess the effects of imatinib and anakinra on PTF and TBF in colorectal cancer metastases in patients.}}, author = {{Lubberink, Mark and Golla, Sandeep S V and Jonasson, My and Rubin, Kristofer and Glimelius, Bengt and Sörensen, Jens and Nygren, Peter}}, issn = {{0161-5505}}, language = {{eng}}, number = {{8}}, pages = {{1144--1149}}, publisher = {{Society of Nuclear Medicine}}, series = {{Journal of Nuclear Medicine}}, title = {{The water-perfusable tissue fraction of colorectal cancer metastases is increased by the selective PDGF-receptor inhibitor imatinib but not the IL-1 receptor antagonist anakinra, a study using serial dynamic 15O-water PET.}}, url = {{http://dx.doi.org/10.2967/jnumed.114.151894}}, doi = {{10.2967/jnumed.114.151894}}, volume = {{56}}, year = {{2015}}, }