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The Prognostic Role of Intratumoral Stromal Content in Lobular Breast Cancer

Forsare, Carina LU orcid ; Vistrand, Sara ; Ehinger, Anna LU orcid ; Lövgren, Kristina LU ; Rydén, Lisa LU orcid ; Fernö, Mårten LU and Narbe, Ulrik LU (2022) In Cancers 14(4).
Abstract

Previous studies have shown that high intratumoral stromal content is associated with a worse prognosis in breast cancer, especially in the triple-negative subtype. However, contradictory results have been reported for estrogen-receptor-positive (ER+) breast cancer, indicating that the prognostic role of intratumoral stromal content may be subtype-dependent. In this study, we investigated the importance of intratumoral stromal content for breast cancer-specific mortality (BCM) in a well-defined subgroup (n = 182) of ER+/human-epidermal growth-factor-receptor-2 negative (HER2−) invasive lobular breast cancer (ILC). The intratumoral stromal content was assessed on hematoxylin–eosin-stained whole sections and graded into high stroma... (More)

Previous studies have shown that high intratumoral stromal content is associated with a worse prognosis in breast cancer, especially in the triple-negative subtype. However, contradictory results have been reported for estrogen-receptor-positive (ER+) breast cancer, indicating that the prognostic role of intratumoral stromal content may be subtype-dependent. In this study, we investigated the importance of intratumoral stromal content for breast cancer-specific mortality (BCM) in a well-defined subgroup (n = 182) of ER+/human-epidermal growth-factor-receptor-2 negative (HER2−) invasive lobular breast cancer (ILC). The intratumoral stromal content was assessed on hematoxylin–eosin-stained whole sections and graded into high stroma (>50%) or low stroma (≤50%). A total of 82 (45%) patients had high-stroma tumors, and 100 (55%) had low-stroma tumors. High-stroma tumors were associated with a lower Nottingham histological grade, low Ki67, and a luminal A-like subtype. After a 10-year follow-up, the patients with high-stroma tumors had a lower BCM (HR: 0.43, 95% CI: 0.21–0.89, p = 0.023) in univariable analysis. Essentially the same effect was found in both the multivariable analysis (10-year follow-up) and univariable analysis (25-year follow-up), but these findings were not strictly significant. In ER+/HER2− ILC, high intratumoral stromal content is an easily assessable histological indicator of a good prognosis.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Intratumoral stroma, Lobular breast cancer, Long-term prognosis
in
Cancers
volume
14
issue
4
article number
941
publisher
MDPI AG
external identifiers
  • pmid:35205688
  • scopus:85124481899
ISSN
2072-6694
DOI
10.3390/cancers14040941
language
English
LU publication?
yes
id
749b1565-b4d1-4a9b-9ff8-d014554a5aaf
date added to LUP
2022-04-13 10:15:56
date last changed
2024-07-02 16:31:02
@article{749b1565-b4d1-4a9b-9ff8-d014554a5aaf,
  abstract     = {{<p>Previous studies have shown that high intratumoral stromal content is associated with a worse prognosis in breast cancer, especially in the triple-negative subtype. However, contradictory results have been reported for estrogen-receptor-positive (ER+) breast cancer, indicating that the prognostic role of intratumoral stromal content may be subtype-dependent. In this study, we investigated the importance of intratumoral stromal content for breast cancer-specific mortality (BCM) in a well-defined subgroup (n = 182) of ER+/human-epidermal growth-factor-receptor-2 negative (HER2−) invasive lobular breast cancer (ILC). The intratumoral stromal content was assessed on hematoxylin–eosin-stained whole sections and graded into high stroma (&gt;50%) or low stroma (≤50%). A total of 82 (45%) patients had high-stroma tumors, and 100 (55%) had low-stroma tumors. High-stroma tumors were associated with a lower Nottingham histological grade, low Ki67, and a luminal A-like subtype. After a 10-year follow-up, the patients with high-stroma tumors had a lower BCM (HR: 0.43, 95% CI: 0.21–0.89, p = 0.023) in univariable analysis. Essentially the same effect was found in both the multivariable analysis (10-year follow-up) and univariable analysis (25-year follow-up), but these findings were not strictly significant. In ER+/HER2− ILC, high intratumoral stromal content is an easily assessable histological indicator of a good prognosis.</p>}},
  author       = {{Forsare, Carina and Vistrand, Sara and Ehinger, Anna and Lövgren, Kristina and Rydén, Lisa and Fernö, Mårten and Narbe, Ulrik}},
  issn         = {{2072-6694}},
  keywords     = {{Intratumoral stroma; Lobular breast cancer; Long-term prognosis}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{The Prognostic Role of Intratumoral Stromal Content in Lobular Breast Cancer}},
  url          = {{http://dx.doi.org/10.3390/cancers14040941}},
  doi          = {{10.3390/cancers14040941}},
  volume       = {{14}},
  year         = {{2022}},
}