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Biological Structures

Fisher, Zoe LU ; Jackson, Andrew LU ; Kovalevsky, Andrey; Oksanen, Esko LU and Wacklin, Hanna LU (2017) In Experimental Methods in the Physical Sciences 49. p.1-75
Abstract

Neutron scattering methods are excellent for probing the detailed structure of biological systems, which rely on the intricate interplay of a large number of molecules from proteins and nucleic acids to lipids, hormones, and metabolites. With recent instrument developments and emergence of both new neutron sources and techniques, many biological systems that are not yet amenable to characterization by neutron scattering will become accessible in the near future, which will allow new experiments to be developed with a range of biologically relevant samples, offering new insights in life science. In this chapter, we will describe neutron methods for biological structure characterization on different length scales from atomic resolution to... (More)

Neutron scattering methods are excellent for probing the detailed structure of biological systems, which rely on the intricate interplay of a large number of molecules from proteins and nucleic acids to lipids, hormones, and metabolites. With recent instrument developments and emergence of both new neutron sources and techniques, many biological systems that are not yet amenable to characterization by neutron scattering will become accessible in the near future, which will allow new experiments to be developed with a range of biologically relevant samples, offering new insights in life science. In this chapter, we will describe neutron methods for biological structure characterization on different length scales from atomic resolution to macromolecular length scales-up to micrometers. The dynamics of biological molecules are described by Seydel in Chapter 2 of this thematic volume.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Crystallization, Deuteration, Macromolecular diffraction, Reflectometry, Small-angle neutron scattering
in
Experimental Methods in the Physical Sciences
volume
49
pages
75 pages
publisher
Academic Press
external identifiers
  • scopus:85024855675
ISSN
10794042
DOI
10.1016/B978-0-12-805324-9.00001-7
language
English
LU publication?
yes
id
74e55ed2-d26e-425c-8103-24582ef0a530
date added to LUP
2017-07-31 13:21:18
date last changed
2017-07-31 13:21:18
@inbook{74e55ed2-d26e-425c-8103-24582ef0a530,
  abstract     = {<p>Neutron scattering methods are excellent for probing the detailed structure of biological systems, which rely on the intricate interplay of a large number of molecules from proteins and nucleic acids to lipids, hormones, and metabolites. With recent instrument developments and emergence of both new neutron sources and techniques, many biological systems that are not yet amenable to characterization by neutron scattering will become accessible in the near future, which will allow new experiments to be developed with a range of biologically relevant samples, offering new insights in life science. In this chapter, we will describe neutron methods for biological structure characterization on different length scales from atomic resolution to macromolecular length scales-up to micrometers. The dynamics of biological molecules are described by Seydel in Chapter 2 of this thematic volume.</p>},
  author       = {Fisher, Zoe and Jackson, Andrew and Kovalevsky, Andrey and Oksanen, Esko and Wacklin, Hanna},
  issn         = {10794042},
  keyword      = {Crystallization,Deuteration,Macromolecular diffraction,Reflectometry,Small-angle neutron scattering},
  language     = {eng},
  pages        = {1--75},
  publisher    = {Academic Press},
  series       = {Experimental Methods in the Physical Sciences},
  title        = {Biological Structures},
  url          = {http://dx.doi.org/10.1016/B978-0-12-805324-9.00001-7},
  volume       = {49},
  year         = {2017},
}