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Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly.

Herlin, Maria LU ; McGuigan, Fiona LU ; Luthman, Holger LU and Åkesson, Kristina LU (2015) In Bone 79. p.105-109
Abstract
ALOX12 and ALOX15 encode arachidonate lipoxygenases which produce lipid metabolites involved in inflammatory processes. Metabolites generated by ALOX12 and ALOX15 can activate the expression of the potent pro-inflammatory cytokine IL-6, and produce endogenous ligands for PPARG. In this study, polymorphisms in ALOX12, ALOX15, IL6 and PPARG were investigated for association with bone properties in young and elderly Swedish women.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Bone
volume
79
pages
105 - 109
publisher
Elsevier
external identifiers
  • pmid:26036173
  • wos:000359509700015
  • scopus:84930945200
ISSN
1873-2763
DOI
10.1016/j.bone.2015.05.035
language
English
LU publication?
yes
id
76e52e2e-a51e-4757-a31f-d256ddf66e3e (old id 7508486)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26036173?dopt=Abstract
date added to LUP
2015-07-06 00:05:12
date last changed
2017-01-01 03:36:00
@article{76e52e2e-a51e-4757-a31f-d256ddf66e3e,
  abstract     = {ALOX12 and ALOX15 encode arachidonate lipoxygenases which produce lipid metabolites involved in inflammatory processes. Metabolites generated by ALOX12 and ALOX15 can activate the expression of the potent pro-inflammatory cytokine IL-6, and produce endogenous ligands for PPARG. In this study, polymorphisms in ALOX12, ALOX15, IL6 and PPARG were investigated for association with bone properties in young and elderly Swedish women.},
  author       = {Herlin, Maria and McGuigan, Fiona and Luthman, Holger and Åkesson, Kristina},
  issn         = {1873-2763},
  language     = {eng},
  pages        = {105--109},
  publisher    = {Elsevier},
  series       = {Bone},
  title        = {Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly.},
  url          = {http://dx.doi.org/10.1016/j.bone.2015.05.035},
  volume       = {79},
  year         = {2015},
}