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Methods to improve patient recruitment and retention in stroke trials

Berge, Eivind; Stapf, Christian; Al-Shahi Salman, Rustam; Ford, Gary A.; Sandercock, Peter; van der Worp, H. Bart; Petersson, Jesper LU ; Dippel, Diederik W J; Krieger, Derk W. and Lees, Kennedy R. (2016) In International Journal of Stroke 11(6). p.663-676
Abstract

Background: The success of randomized-controlled stroke trials is dependent on the recruitment and retention of a sufficient number of patients, but fewer than half of all trials meet their target number of patients. Methods: We performed a search and review of the literature, and conducted a survey and workshop among 56 European stroke trialists, to identify barriers, suggest methods to improve recruitment and retention, and make a priority list of interventions that merit further evaluation. Results: The survey and workshop identified a number of barriers to patient recruitment and retention, from patients’ incapacity to consent, to handicaps that prevent patients from participation in trial-specific follow-up. Methods to improve... (More)

Background: The success of randomized-controlled stroke trials is dependent on the recruitment and retention of a sufficient number of patients, but fewer than half of all trials meet their target number of patients. Methods: We performed a search and review of the literature, and conducted a survey and workshop among 56 European stroke trialists, to identify barriers, suggest methods to improve recruitment and retention, and make a priority list of interventions that merit further evaluation. Results: The survey and workshop identified a number of barriers to patient recruitment and retention, from patients’ incapacity to consent, to handicaps that prevent patients from participation in trial-specific follow-up. Methods to improve recruitment and retention may include simple interventions with individual participants, funding of research networks, and reimbursement of new treatments by health services only when delivered within clinical trials. The literature review revealed that few methods have been formally evaluated. The top five priorities for evaluation identified in the workshop were as follows: short and illustrated patient information leaflets, nonwritten consent, reimbursement for new interventions only within a study, and monetary incentives to institutions taking part in research (for recruitment); and involvement of patient groups, remote and central follow-up, use of mobile devices, and reminders to patients about their consent to participate (for retention). Conclusions: Many interventions have been used with the aim of improving recruitment and retention of patients in stroke studies, but only a minority has been evaluated. We have identified methods that could be tested, and propose that such evaluations may be nested within on-going clinical trials.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acute stroke therapy, clinical trial, methodological research, prevention, recruitment, rehabilitation, retention, Stroke, stroke trial, studies within a trial
in
International Journal of Stroke
volume
11
issue
6
pages
14 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:84979955976
  • wos:000380990700012
ISSN
1747-4930
DOI
10.1177/1747493016641963
language
English
LU publication?
yes
id
751f0873-fa1a-4ad3-bcf8-2892d4fc8215
date added to LUP
2016-12-14 11:36:15
date last changed
2017-09-18 11:31:19
@article{751f0873-fa1a-4ad3-bcf8-2892d4fc8215,
  abstract     = {<p>Background: The success of randomized-controlled stroke trials is dependent on the recruitment and retention of a sufficient number of patients, but fewer than half of all trials meet their target number of patients. Methods: We performed a search and review of the literature, and conducted a survey and workshop among 56 European stroke trialists, to identify barriers, suggest methods to improve recruitment and retention, and make a priority list of interventions that merit further evaluation. Results: The survey and workshop identified a number of barriers to patient recruitment and retention, from patients’ incapacity to consent, to handicaps that prevent patients from participation in trial-specific follow-up. Methods to improve recruitment and retention may include simple interventions with individual participants, funding of research networks, and reimbursement of new treatments by health services only when delivered within clinical trials. The literature review revealed that few methods have been formally evaluated. The top five priorities for evaluation identified in the workshop were as follows: short and illustrated patient information leaflets, nonwritten consent, reimbursement for new interventions only within a study, and monetary incentives to institutions taking part in research (for recruitment); and involvement of patient groups, remote and central follow-up, use of mobile devices, and reminders to patients about their consent to participate (for retention). Conclusions: Many interventions have been used with the aim of improving recruitment and retention of patients in stroke studies, but only a minority has been evaluated. We have identified methods that could be tested, and propose that such evaluations may be nested within on-going clinical trials.</p>},
  author       = {Berge, Eivind and Stapf, Christian and Al-Shahi Salman, Rustam and Ford, Gary A. and Sandercock, Peter and van der Worp, H. Bart and Petersson, Jesper and Dippel, Diederik W J and Krieger, Derk W. and Lees, Kennedy R.},
  issn         = {1747-4930},
  keyword      = {acute stroke therapy,clinical trial,methodological research,prevention,recruitment,rehabilitation,retention,Stroke,stroke trial,studies within a trial},
  language     = {eng},
  month        = {08},
  number       = {6},
  pages        = {663--676},
  publisher    = {Wiley-Blackwell},
  series       = {International Journal of Stroke},
  title        = {Methods to improve patient recruitment and retention in stroke trials},
  url          = {http://dx.doi.org/10.1177/1747493016641963},
  volume       = {11},
  year         = {2016},
}