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Oral administration of lactobacillus and Bifidobacterium strains of intestinal and vaginal origin to healthy human females: re-isolation from faeces and vagina

Vásquez, A; Ahrné, Siv LU ; Jeppsson, Bengt LU and Molin, Göran LU (2005) In Microbial Ecology in Health and Disease 17(1). p.15-20
Abstract
The healthy vaginal ecosystem is maintained by the interaction of the vaginal epithelium and the microflora, where lactobacilli and occasionally bifidobacteria play an important role. Imbalances in the dominance of lactobacilli may lead to bacterial vaginosis or yeast vaginitis. Probiotics may be a means to secure a favourable microbial balance in the vagina and, as the normal vaginal flora ascends from the rectal mucosa, a convenient form of administration may be via the oral gastrointestinal route. Ten healthy women of different ages were orally administered a blend of 12 selected Lactobacillus strains and three Bifidobacterium strains originating from the intestine and the vagina. The daily dose of each Lactobacillus strain was 1-3×109... (More)
The healthy vaginal ecosystem is maintained by the interaction of the vaginal epithelium and the microflora, where lactobacilli and occasionally bifidobacteria play an important role. Imbalances in the dominance of lactobacilli may lead to bacterial vaginosis or yeast vaginitis. Probiotics may be a means to secure a favourable microbial balance in the vagina and, as the normal vaginal flora ascends from the rectal mucosa, a convenient form of administration may be via the oral gastrointestinal route. Ten healthy women of different ages were orally administered a blend of 12 selected Lactobacillus strains and three Bifidobacterium strains originating from the intestine and the vagina. The daily dose of each Lactobacillus strain was 1-3×109 CFU and 1×108 to 1×109 CFU for each Bifidobacterium strain, and the doses were given in an oatmilk/blueberry drink. The treatment went on for 10 days. Samples of faeces and vaginal fluid were taken immediately before the administration was started, after 10 days of administration and 7 days after the termination of the administration. Five strains were recovered from faeces and three from the vagina after treatment. The test strains could be found in 9 of the 10 volunteers. L. plantarum strains, originally isolated from intestinal mucosa, were recovered from the vagina of five subjects after treatment. The L. plantarum strains, together with one strain of L. crispatus and one L. gasseri strain, were recovered from faeces. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Microbial Ecology in Health and Disease
volume
17
issue
1
pages
15 - 20
publisher
Taylor & Francis
external identifiers
  • scopus:18844367206
ISSN
0891-060X
language
English
LU publication?
yes
id
30864d6a-7dc5-4048-9069-6c9f62fbfa21 (old id 756886)
date added to LUP
2008-01-09 11:11:25
date last changed
2017-10-29 03:33:26
@article{30864d6a-7dc5-4048-9069-6c9f62fbfa21,
  abstract     = {The healthy vaginal ecosystem is maintained by the interaction of the vaginal epithelium and the microflora, where lactobacilli and occasionally bifidobacteria play an important role. Imbalances in the dominance of lactobacilli may lead to bacterial vaginosis or yeast vaginitis. Probiotics may be a means to secure a favourable microbial balance in the vagina and, as the normal vaginal flora ascends from the rectal mucosa, a convenient form of administration may be via the oral gastrointestinal route. Ten healthy women of different ages were orally administered a blend of 12 selected Lactobacillus strains and three Bifidobacterium strains originating from the intestine and the vagina. The daily dose of each Lactobacillus strain was 1-3×109 CFU and 1×108 to 1×109 CFU for each Bifidobacterium strain, and the doses were given in an oatmilk/blueberry drink. The treatment went on for 10 days. Samples of faeces and vaginal fluid were taken immediately before the administration was started, after 10 days of administration and 7 days after the termination of the administration. Five strains were recovered from faeces and three from the vagina after treatment. The test strains could be found in 9 of the 10 volunteers. L. plantarum strains, originally isolated from intestinal mucosa, were recovered from the vagina of five subjects after treatment. The L. plantarum strains, together with one strain of L. crispatus and one L. gasseri strain, were recovered from faeces.},
  author       = {Vásquez, A and Ahrné, Siv and Jeppsson, Bengt and Molin, Göran},
  issn         = {0891-060X},
  language     = {eng},
  number       = {1},
  pages        = {15--20},
  publisher    = {Taylor & Francis},
  series       = {Microbial Ecology in Health and Disease},
  title        = {Oral administration of lactobacillus and Bifidobacterium strains of intestinal and vaginal origin to healthy human females: re-isolation from faeces and vagina},
  volume       = {17},
  year         = {2005},
}