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Development of immunocompetence: role of micronutrients and microorganisms

Ahrné, Siv LU ; Abuav-Nussbaum, B S and Dnistian, A (2002) In Nutritional Reviews 60(Supplement 1). p.68-72
Abstract
Normal maturation of immune response at birth is both supported and stimulated by the gastrointestinal microenvironment, which provides both nutrients and antigenic microbial exposure to the developing child. Micronutrients, trace elements, and vitamins are present in the local environment and have important regulatory effects on adaptive immune cell function through effects on type of cytokine response. Congenital HIV infection is critically affected by both nutrient imbalance and alteration in gastrointestinal microflora, which may impair growth and development as well as immune response. Studies described here indicate that micronutrient deficiency is common in congenital HIV exposure even where infection has not occurred and that... (More)
Normal maturation of immune response at birth is both supported and stimulated by the gastrointestinal microenvironment, which provides both nutrients and antigenic microbial exposure to the developing child. Micronutrients, trace elements, and vitamins are present in the local environment and have important regulatory effects on adaptive immune cell function through effects on type of cytokine response. Congenital HIV infection is critically affected by both nutrient imbalance and alteration in gastrointestinal microflora, which may impair growth and development as well as immune response. Studies described here indicate that micronutrient deficiency is common in congenital HIV exposure even where infection has not occurred and that gastrointestinal recolonization may exert a restorative effect on both immune response and growth in children with HIV infection. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nutritional Reviews
volume
60
issue
Supplement 1
pages
68 - 72
publisher
International Life Sciences Institute
external identifiers
  • Scopus:0036092213
language
English
LU publication?
yes
id
7255dbfd-be4d-4b4d-a8f7-fb5dae2404c7 (old id 756997)
date added to LUP
2007-12-14 17:33:04
date last changed
2017-01-01 08:04:21
@article{7255dbfd-be4d-4b4d-a8f7-fb5dae2404c7,
  abstract     = {Normal maturation of immune response at birth is both supported and stimulated by the gastrointestinal microenvironment, which provides both nutrients and antigenic microbial exposure to the developing child. Micronutrients, trace elements, and vitamins are present in the local environment and have important regulatory effects on adaptive immune cell function through effects on type of cytokine response. Congenital HIV infection is critically affected by both nutrient imbalance and alteration in gastrointestinal microflora, which may impair growth and development as well as immune response. Studies described here indicate that micronutrient deficiency is common in congenital HIV exposure even where infection has not occurred and that gastrointestinal recolonization may exert a restorative effect on both immune response and growth in children with HIV infection.},
  author       = {Ahrné, Siv and Abuav-Nussbaum, B S and Dnistian, A},
  language     = {eng},
  number       = {Supplement 1},
  pages        = {68--72},
  publisher    = {International Life Sciences Institute},
  series       = {Nutritional Reviews},
  title        = {Development of immunocompetence: role of micronutrients and microorganisms},
  volume       = {60},
  year         = {2002},
}