Epilepsy surgery in children with drug-resistant epilepsy, a long-term follow-up
(2013) In Acta Neurologica Scandinavica 128(6). p.414-421- Abstract
- ObjectivesIn this follow-up study, we wanted to present the long-term outcome (5-21years) in terms of seizure freedom, seizure reduction, and the cognitive development in the first 47 children who underwent epilepsy surgery at the University Hospital in Lund from 1991 to 2007. Materials and methodsAll children who underwent epilepsy surgery in the southern region of Sweden were assessed for cognitive function before surgery and at follow-up. A review of medical documents for demographic data and seizure-related characteristics was made by retrospectively examining the clinical records. ResultsForty-seven children with a median age at surgery of 8years (range 0.5-18.7years) were included. Twenty-three children achieved seizure freedom, six... (More)
- ObjectivesIn this follow-up study, we wanted to present the long-term outcome (5-21years) in terms of seizure freedom, seizure reduction, and the cognitive development in the first 47 children who underwent epilepsy surgery at the University Hospital in Lund from 1991 to 2007. Materials and methodsAll children who underwent epilepsy surgery in the southern region of Sweden were assessed for cognitive function before surgery and at follow-up. A review of medical documents for demographic data and seizure-related characteristics was made by retrospectively examining the clinical records. ResultsForty-seven children with a median age at surgery of 8years (range 0.5-18.7years) were included. Twenty-three children achieved seizure freedom, six demonstrated >75% improvement in seizure frequency, and none of the children experienced an increase in seizure frequency. Twenty-one children required a reoperation to achieve satisfactory seizure outcomes. Cognitive functional level was preserved, and the majority of patients, 34 (76%), followed their expected cognitive trajectory. The patients who became seizure free significantly improved their cognitive processing speed, even after long-term follow-up. ConclusionsEpilepsy surgery in children offers suitable candidates a good chance of significantly improved outcome and low rates of complications. Several children, however, required a reoperation to achieve satisfactory seizure outcomes. Cognitive level was preserved, and the majority of patients followed their expected cognitive trajectory. Cognitive improvements in processing speed appear to occur in parallel with seizure control and were even more pronounced in subjects with no anti-epilepsy drugs. These improvements persisted even after long-term follow-up. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4157891
- author
- Hallbook, T. ; Tideman, P. ; Rosén, Ingmar LU ; Lundgren, Johan LU and Tideman, Eva LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- children, cognitive function, epilepsy surgery, long-term follow-up, outcome, seizure freedom
- in
- Acta Neurologica Scandinavica
- volume
- 128
- issue
- 6
- pages
- 414 - 421
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000326068600011
- scopus:84886641944
- pmid:23742270
- ISSN
- 1600-0404
- DOI
- 10.1111/ane.12154
- language
- English
- LU publication?
- yes
- id
- 756ff757-cb89-487d-9177-b18e67c9e65b (old id 4157891)
- date added to LUP
- 2016-04-01 15:01:58
- date last changed
- 2022-03-14 17:00:27
@article{756ff757-cb89-487d-9177-b18e67c9e65b,
abstract = {{ObjectivesIn this follow-up study, we wanted to present the long-term outcome (5-21years) in terms of seizure freedom, seizure reduction, and the cognitive development in the first 47 children who underwent epilepsy surgery at the University Hospital in Lund from 1991 to 2007. Materials and methodsAll children who underwent epilepsy surgery in the southern region of Sweden were assessed for cognitive function before surgery and at follow-up. A review of medical documents for demographic data and seizure-related characteristics was made by retrospectively examining the clinical records. ResultsForty-seven children with a median age at surgery of 8years (range 0.5-18.7years) were included. Twenty-three children achieved seizure freedom, six demonstrated >75% improvement in seizure frequency, and none of the children experienced an increase in seizure frequency. Twenty-one children required a reoperation to achieve satisfactory seizure outcomes. Cognitive functional level was preserved, and the majority of patients, 34 (76%), followed their expected cognitive trajectory. The patients who became seizure free significantly improved their cognitive processing speed, even after long-term follow-up. ConclusionsEpilepsy surgery in children offers suitable candidates a good chance of significantly improved outcome and low rates of complications. Several children, however, required a reoperation to achieve satisfactory seizure outcomes. Cognitive level was preserved, and the majority of patients followed their expected cognitive trajectory. Cognitive improvements in processing speed appear to occur in parallel with seizure control and were even more pronounced in subjects with no anti-epilepsy drugs. These improvements persisted even after long-term follow-up.}},
author = {{Hallbook, T. and Tideman, P. and Rosén, Ingmar and Lundgren, Johan and Tideman, Eva}},
issn = {{1600-0404}},
keywords = {{children; cognitive function; epilepsy surgery; long-term follow-up; outcome; seizure freedom}},
language = {{eng}},
number = {{6}},
pages = {{414--421}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Neurologica Scandinavica}},
title = {{Epilepsy surgery in children with drug-resistant epilepsy, a long-term follow-up}},
url = {{http://dx.doi.org/10.1111/ane.12154}},
doi = {{10.1111/ane.12154}},
volume = {{128}},
year = {{2013}},
}