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Familial risk of pleural mesothelioma increased drastically in certain occupations : A nationwide prospective cohort study

Kharazmi, Elham LU ; Chen, Tianhui LU ; Fallah, Mahdi LU ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Albin, Maria LU ; Weiderpass, Elisabete and Hemminki, Kari LU (2018) In European Journal of Cancer 103. p.1-6
Abstract

Objective: We aimed to explore the effect of occupation on familial risk of pleural mesothelioma in a nationwide cohort study design. Method: The nationwide Swedish Family-Cancer Database includes all Swedes born after 1931 and their biological parents, totalling 16.1 million individuals with about 2.3 million cancer patients. Hazards ratios (HRs) were calculated adjusting for age, sex and region of residence. Results: Having asbestos-related occupation in the absence of family history of mesothelioma increased risk of mesothelioma more than threefold (adjusted HR = 3.2, 95% confidence interval [CI]: 3.0–3.5). In those who had a history of mesothelioma in their first-degree relatives and an asbestos-related occupation, risk of... (More)

Objective: We aimed to explore the effect of occupation on familial risk of pleural mesothelioma in a nationwide cohort study design. Method: The nationwide Swedish Family-Cancer Database includes all Swedes born after 1931 and their biological parents, totalling 16.1 million individuals with about 2.3 million cancer patients. Hazards ratios (HRs) were calculated adjusting for age, sex and region of residence. Results: Having asbestos-related occupation in the absence of family history of mesothelioma increased risk of mesothelioma more than threefold (adjusted HR = 3.2, 95% confidence interval [CI]: 3.0–3.5). In those who had a history of mesothelioma in their first-degree relatives and an asbestos-related occupation, risk of mesothelioma dramatically increased compared with individuals without such occupations and family history (without chronic obstructive pulmonary disease [COPD] HR = 24, 95% CI: 15–39; with COPD 45, 95% CI: 15–141). In those who had a family history of mesothelioma and no history of an asbestos-related occupation, risk of mesothelioma did not show significant increase compared with those who had no family history of mesothelioma and no asbestos-related occupation (HR = 1.6; 95% CI: 0.7–3.8). Conclusion: First-degree relatives of patients with pleural mesothelioma had a drastic risk of developing this malignancy in case of certain occupations, which shows a gene–environment interaction is probable in risk of mesothelioma.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Familial risk, First-degree relatives, Mesothelioma, Occupation
in
European Journal of Cancer
volume
103
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:85052921746
  • pmid:30196105
ISSN
0959-8049
DOI
10.1016/j.ejca.2018.07.139
language
English
LU publication?
yes
id
75b9293d-200d-4e67-972c-4f78d32c275f
date added to LUP
2018-10-09 08:52:10
date last changed
2020-09-16 03:56:59
@article{75b9293d-200d-4e67-972c-4f78d32c275f,
  abstract     = {<p>Objective: We aimed to explore the effect of occupation on familial risk of pleural mesothelioma in a nationwide cohort study design. Method: The nationwide Swedish Family-Cancer Database includes all Swedes born after 1931 and their biological parents, totalling 16.1 million individuals with about 2.3 million cancer patients. Hazards ratios (HRs) were calculated adjusting for age, sex and region of residence. Results: Having asbestos-related occupation in the absence of family history of mesothelioma increased risk of mesothelioma more than threefold (adjusted HR = 3.2, 95% confidence interval [CI]: 3.0–3.5). In those who had a history of mesothelioma in their first-degree relatives and an asbestos-related occupation, risk of mesothelioma dramatically increased compared with individuals without such occupations and family history (without chronic obstructive pulmonary disease [COPD] HR = 24, 95% CI: 15–39; with COPD 45, 95% CI: 15–141). In those who had a family history of mesothelioma and no history of an asbestos-related occupation, risk of mesothelioma did not show significant increase compared with those who had no family history of mesothelioma and no asbestos-related occupation (HR = 1.6; 95% CI: 0.7–3.8). Conclusion: First-degree relatives of patients with pleural mesothelioma had a drastic risk of developing this malignancy in case of certain occupations, which shows a gene–environment interaction is probable in risk of mesothelioma.</p>},
  author       = {Kharazmi, Elham and Chen, Tianhui and Fallah, Mahdi and Sundquist, Kristina and Sundquist, Jan and Albin, Maria and Weiderpass, Elisabete and Hemminki, Kari},
  issn         = {0959-8049},
  language     = {eng},
  pages        = {1--6},
  publisher    = {Elsevier},
  series       = {European Journal of Cancer},
  title        = {Familial risk of pleural mesothelioma increased drastically in certain occupations : A nationwide prospective cohort study},
  url          = {http://dx.doi.org/10.1016/j.ejca.2018.07.139},
  doi          = {10.1016/j.ejca.2018.07.139},
  volume       = {103},
  year         = {2018},
}