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Construction of polyamine-modified uridine and adenosine derivatives-evaluation of DNA binding capacity and cytotoxicity in vitro

Ghatnekar, Johannes; Hägerlöf, Margareta LU ; Oredsson, Stina LU ; Alm, Kersti LU ; Elmroth, Sofi LU and Persson, Tina LU (2007) In Bioorganic & Medicinal Chemistry 15(23). p.7426-7433
Abstract
We here report the synthesis of the two polyamine-based nucleoside derivatives 5-{[bis-(3-aminopropyl)amino]acetamido-1-propynyl}uridine and 2-{[bis-(3-aminopropyl)amino]-acetamido-1-propynyl}adenosine. The various polyamine derivatives have been used in thermal melting analysis using DNA from herring testes, and in cellular studies using four different cell lines. The compounds were all found to be non-toxic, thus holding good promise for future use as siRNA building blocks.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Modified nucleoside, Adenosine, Uridine, Polyamine derivatives
in
Bioorganic & Medicinal Chemistry
volume
15
issue
23
pages
7426 - 7433
publisher
Elsevier
external identifiers
  • wos:000253489100021
  • scopus:35148885337
ISSN
0968-0896
DOI
10.1016/j.bmc.2007.07.030
language
English
LU publication?
yes
id
416ac1b3-c842-40fa-8d2e-8ca4d0d2088d (old id 760344)
date added to LUP
2007-12-17 13:02:34
date last changed
2017-01-01 04:50:56
@article{416ac1b3-c842-40fa-8d2e-8ca4d0d2088d,
  abstract     = {We here report the synthesis of the two polyamine-based nucleoside derivatives 5-{[bis-(3-aminopropyl)amino]acetamido-1-propynyl}uridine and 2-{[bis-(3-aminopropyl)amino]-acetamido-1-propynyl}adenosine. The various polyamine derivatives have been used in thermal melting analysis using DNA from herring testes, and in cellular studies using four different cell lines. The compounds were all found to be non-toxic, thus holding good promise for future use as siRNA building blocks.},
  author       = {Ghatnekar, Johannes and Hägerlöf, Margareta and Oredsson, Stina and Alm, Kersti and Elmroth, Sofi and Persson, Tina},
  issn         = {0968-0896},
  keyword      = {Modified nucleoside,Adenosine,Uridine,Polyamine derivatives},
  language     = {eng},
  number       = {23},
  pages        = {7426--7433},
  publisher    = {Elsevier},
  series       = {Bioorganic & Medicinal Chemistry},
  title        = {Construction of polyamine-modified uridine and adenosine derivatives-evaluation of DNA binding capacity and cytotoxicity in vitro},
  url          = {http://dx.doi.org/10.1016/j.bmc.2007.07.030},
  volume       = {15},
  year         = {2007},
}