Construction of polyamine-modified uridine and adenosine derivatives-evaluation of DNA binding capacity and cytotoxicity in vitro
(2007) In Bioorganic & Medicinal Chemistry 15(23). p.7426-7433- Abstract
- We here report the synthesis of the two polyamine-based nucleoside derivatives 5-{[bis-(3-aminopropyl)amino]acetamido-1-propynyl}uridine and 2-{[bis-(3-aminopropyl)amino]-acetamido-1-propynyl}adenosine. The various polyamine derivatives have been used in thermal melting analysis using DNA from herring testes, and in cellular studies using four different cell lines. The compounds were all found to be non-toxic, thus holding good promise for future use as siRNA building blocks.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/760344
- author
- Ghatnekar, Johannes ; Hägerlöf, Margareta LU ; Oredsson, Stina LU ; Alm, Kersti LU ; Elmroth, Sofi LU and Persson, Tina LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Modified nucleoside, Adenosine, Uridine, Polyamine derivatives
- in
- Bioorganic & Medicinal Chemistry
- volume
- 15
- issue
- 23
- pages
- 7426 - 7433
- publisher
- Elsevier
- external identifiers
-
- wos:000253489100021
- scopus:35148885337
- ISSN
- 0968-0896
- DOI
- 10.1016/j.bmc.2007.07.030
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Functional Zoology (432112239), Biochemistry and Structural Biology (S) (000006142), Department of Biology (000016100), Organic chemistry (S/LTH) (011001240)
- id
- 416ac1b3-c842-40fa-8d2e-8ca4d0d2088d (old id 760344)
- date added to LUP
- 2016-04-01 12:06:53
- date last changed
- 2024-07-01 11:25:17
@article{416ac1b3-c842-40fa-8d2e-8ca4d0d2088d, abstract = {{We here report the synthesis of the two polyamine-based nucleoside derivatives 5-{[bis-(3-aminopropyl)amino]acetamido-1-propynyl}uridine and 2-{[bis-(3-aminopropyl)amino]-acetamido-1-propynyl}adenosine. The various polyamine derivatives have been used in thermal melting analysis using DNA from herring testes, and in cellular studies using four different cell lines. The compounds were all found to be non-toxic, thus holding good promise for future use as siRNA building blocks.}}, author = {{Ghatnekar, Johannes and Hägerlöf, Margareta and Oredsson, Stina and Alm, Kersti and Elmroth, Sofi and Persson, Tina}}, issn = {{0968-0896}}, keywords = {{Modified nucleoside; Adenosine; Uridine; Polyamine derivatives}}, language = {{eng}}, number = {{23}}, pages = {{7426--7433}}, publisher = {{Elsevier}}, series = {{Bioorganic & Medicinal Chemistry}}, title = {{Construction of polyamine-modified uridine and adenosine derivatives-evaluation of DNA binding capacity and cytotoxicity in vitro}}, url = {{http://dx.doi.org/10.1016/j.bmc.2007.07.030}}, doi = {{10.1016/j.bmc.2007.07.030}}, volume = {{15}}, year = {{2007}}, }