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Kernel-based Estimate of the Insulin Action of Rapid-Acting Insulin in Home-Monitored Data

Ståhl, Fredrik LU ; Lindström, Erik LU orcid ; Landin-Olsson, Mona LU and Johansson, Rolf LU orcid (2015) In IFAC-PapersOnLine 48(28). p.715-720
Abstract
To improve glycemic control in insulin-dependent diabetes, estimates of the glucose- lowering effect of insulin-the insulin action (IA)-and the dynamics thereof are essential. The current practice relies on generic estimates of the dynamic shape of the IA and rules-of-thumb to assess the total glucose-lowering effect. In this paper we present individualized estimates based on home-monitored data, incorporating a kernel-based estimate that also accounts for the nonlinear behavior of the IA across the glucose range. The method is successfully validated on 29 patients on continuous insulin pump therapy.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
IFAC-PapersOnLine
volume
48
issue
28
pages
6 pages
publisher
IFAC Secretariat
external identifiers
  • scopus:84988484495
ISSN
2405-8963
DOI
10.1016/j.ifacol.2015.12.214
project
DIAdvisor
language
English
LU publication?
yes
id
7662b5f2-86b0-4405-9f27-3367a3d50f8a
date added to LUP
2016-09-13 13:20:13
date last changed
2022-06-17 12:58:39
@article{7662b5f2-86b0-4405-9f27-3367a3d50f8a,
  abstract     = {{To improve glycemic control in insulin-dependent diabetes, estimates of the glucose- lowering effect of insulin-the insulin action (IA)-and the dynamics thereof are essential. The current practice relies on generic estimates of the dynamic shape of the IA and rules-of-thumb to assess the total glucose-lowering effect. In this paper we present individualized estimates based on home-monitored data, incorporating a kernel-based estimate that also accounts for the nonlinear behavior of the IA across the glucose range. The method is successfully validated on 29 patients on continuous insulin pump therapy.}},
  author       = {{Ståhl, Fredrik and Lindström, Erik and Landin-Olsson, Mona and Johansson, Rolf}},
  issn         = {{2405-8963}},
  language     = {{eng}},
  number       = {{28}},
  pages        = {{715--720}},
  publisher    = {{IFAC Secretariat}},
  series       = {{IFAC-PapersOnLine}},
  title        = {{Kernel-based Estimate of the Insulin Action of Rapid-Acting Insulin in Home-Monitored Data}},
  url          = {{http://dx.doi.org/10.1016/j.ifacol.2015.12.214}},
  doi          = {{10.1016/j.ifacol.2015.12.214}},
  volume       = {{48}},
  year         = {{2015}},
}