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Kernel-based Estimate of the Insulin Action of Rapid-Acting Insulin in Home-Monitored Data

Ståhl, Fredrik LU ; Lindström, Erik LU ; Landin-Olsson, Mona LU and Johansson, Rolf LU (2015) In IFAC-PapersOnLine 48. p.715-720
Abstract
To improve glycemic control in insulin-dependent diabetes, estimates of the glucose- lowering effect of insulin-the insulin action (IA)-and the dynamics thereof are essential. The current practice relies on generic estimates of the dynamic shape of the IA and rules-of-thumb to assess the total glucose-lowering effect. In this paper we present individualized estimates based on home-monitored data, incorporating a kernel-based estimate that also accounts for the nonlinear behavior of the IA across the glucose range. The method is successfully validated on 29 patients on continuous insulin pump therapy.
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
IFAC-PapersOnLine
volume
48
pages
5 pages
publisher
IFAC
external identifiers
  • Scopus:84988484495
DOI
10.1016/j.ifacol.2015.12.214
language
English
LU publication?
yes
id
7662b5f2-86b0-4405-9f27-3367a3d50f8a
date added to LUP
2016-09-13 13:20:13
date last changed
2017-02-16 15:31:03
@inproceedings{7662b5f2-86b0-4405-9f27-3367a3d50f8a,
  abstract     = {To improve glycemic control in insulin-dependent diabetes, estimates of the glucose- lowering effect of insulin-the insulin action (IA)-and the dynamics thereof are essential. The current practice relies on generic estimates of the dynamic shape of the IA and rules-of-thumb to assess the total glucose-lowering effect. In this paper we present individualized estimates based on home-monitored data, incorporating a kernel-based estimate that also accounts for the nonlinear behavior of the IA across the glucose range. The method is successfully validated on 29 patients on continuous insulin pump therapy.},
  author       = {Ståhl, Fredrik and Lindström, Erik and Landin-Olsson, Mona and Johansson, Rolf},
  booktitle    = {IFAC-PapersOnLine},
  language     = {eng},
  pages        = {715--720},
  publisher    = {IFAC},
  title        = {Kernel-based Estimate of the Insulin Action of Rapid-Acting Insulin in Home-Monitored Data},
  url          = {http://dx.doi.org/10.1016/j.ifacol.2015.12.214},
  volume       = {48},
  year         = {2015},
}