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Impact of time to return of spontaneous circulation on neuroprotective effect of targeted temperature management at 33 or 36 degrees in comatose survivors of out-of hospital cardiac arrest.

Kjaergaard, Jesper; Nielsen, Niklas LU ; Winther-Jensen, Matilde; Wanscher, Michael; Pellis, Tommaso; Kuiper, Ichael; Hartvig Thomsen, Jakob; Wetterslev, Jørn; Cronberg, Tobias LU and Bro-Jeppesen, John, et al. (2015) In Resuscitation 96(Jul 7). p.310-316
Abstract
Time to Return of Spontaneous Circulation (ROSC) has a plausible relation to severity of hypoxic injury before and during resuscitation in Out-of-Hospital Cardiac Arrest (OHCA), and has consistently been associated with adverse outcome. The effect of Targeted Temperature Management (TTM) may not be similar over the full spectrum of time to ROSC. This study investigated the possible beneficial effect of targeting 33°C over 36°C on the prognostic importance of time to ROSC.
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type
Contribution to journal
publication status
published
subject
in
Resuscitation
volume
96
issue
Jul 7
pages
310 - 316
publisher
Elsevier
external identifiers
  • pmid:26159609
  • wos:000366584500057
  • scopus:84945451471
ISSN
1873-1570
DOI
10.1016/j.resuscitation.2015.06.021
language
English
LU publication?
yes
id
a02daf34-177c-470a-9101-f6dafc0be0ec (old id 7749955)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26159609?dopt=Abstract
date added to LUP
2015-08-07 00:57:16
date last changed
2017-11-05 03:13:12
@article{a02daf34-177c-470a-9101-f6dafc0be0ec,
  abstract     = {Time to Return of Spontaneous Circulation (ROSC) has a plausible relation to severity of hypoxic injury before and during resuscitation in Out-of-Hospital Cardiac Arrest (OHCA), and has consistently been associated with adverse outcome. The effect of Targeted Temperature Management (TTM) may not be similar over the full spectrum of time to ROSC. This study investigated the possible beneficial effect of targeting 33°C over 36°C on the prognostic importance of time to ROSC.},
  author       = {Kjaergaard, Jesper and Nielsen, Niklas and Winther-Jensen, Matilde and Wanscher, Michael and Pellis, Tommaso and Kuiper, Ichael and Hartvig Thomsen, Jakob and Wetterslev, Jørn and Cronberg, Tobias and Bro-Jeppesen, John and Erlinge, David and Friberg, Hans and Søholm, Helle and Gasche, Yvan and Horn, Janneke and Hovdenes, Jan and Stammet, Pascal and Wise, Matthew P and Åneman, Anders and Hassager, Christian},
  issn         = {1873-1570},
  language     = {eng},
  number       = {Jul 7},
  pages        = {310--316},
  publisher    = {Elsevier},
  series       = {Resuscitation},
  title        = {Impact of time to return of spontaneous circulation on neuroprotective effect of targeted temperature management at 33 or 36 degrees in comatose survivors of out-of hospital cardiac arrest.},
  url          = {http://dx.doi.org/10.1016/j.resuscitation.2015.06.021},
  volume       = {96},
  year         = {2015},
}