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Measurement of vascular water transport in human subjects using time-resolved pulsed arterial spin labelling.

Bibic, Adnan LU ; Knutsson, Linda LU ; Schmidt, Anders LU ; Henningsson, Erik LU ; Månsson, Sven LU ; Abul-Kasim, Kasim LU ; Åkeson, Jonas LU ; Gunther, Matthias; Ståhlberg, Freddy LU and Wirestam, Ronnie LU (2015) In NMR in Biomedicine 28(8). p.1059-1068
Abstract
Most approaches to arterial spin labelling (ASL) data analysis aim to provide a quantitative measure of the cerebral blood flow (CBF). This study, however, focuses on the measurement of the transfer time of blood water through the capillaries to the parenchyma (referred to as the capillary transfer time, CTT) as an alternative parameter to characterise the haemodynamics of the system. The method employed is based on a non-compartmental model, and no measurements need to be added to a common time-resolved ASL experiment. Brownian motion of labelled spins in a potential was described by a one-dimensional general Langevin equation as the starting point, and as a Fokker-Planck differential equation for the averaged distribution of labelled... (More)
Most approaches to arterial spin labelling (ASL) data analysis aim to provide a quantitative measure of the cerebral blood flow (CBF). This study, however, focuses on the measurement of the transfer time of blood water through the capillaries to the parenchyma (referred to as the capillary transfer time, CTT) as an alternative parameter to characterise the haemodynamics of the system. The method employed is based on a non-compartmental model, and no measurements need to be added to a common time-resolved ASL experiment. Brownian motion of labelled spins in a potential was described by a one-dimensional general Langevin equation as the starting point, and as a Fokker-Planck differential equation for the averaged distribution of labelled spins at the end point, which takes into account the effects of flow and dispersion of labelled water by the pseudorandom nature of the microvasculature and the transcapillary permeability. Multi-inversion time (multi-TI) ASL data were acquired in 14 healthy subjects on two occasions in a test-retest design, using a pulsed ASL sequence and three-dimensional gradient and spin echo (3D-GRASE) readout. Based on an error analysis to predict the size of a region of interest (ROI) required to obtain reasonably precise parameter estimates, data were analysed in two relatively large ROIs, i.e. the occipital lobe (OC) and the insular cortex (IC). The average values of CTT in OC were 260 ± 60 ms in the first experiment and 270 ± 60 ms in the second experiment. The corresponding IC values were 460 ± 130 ms and 420 ± 139 ms, respectively. Information related to the water transfer time may be important for diagnostics and follow-up of cerebral conditions or diseases characterised by a disrupted blood-brain barrier or disturbed capillary blood flow. Copyright © 2015 John Wiley & Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NMR in Biomedicine
volume
28
issue
8
pages
1059 - 1068
publisher
John Wiley & Sons
external identifiers
  • pmid:26147641
  • wos:000358174600014
  • scopus:84937251606
ISSN
0952-3480
DOI
10.1002/nbm.3344
language
English
LU publication?
yes
id
13bdf236-4ed4-49bc-81d9-6cfccc9c7f4e (old id 7750606)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26147641?dopt=Abstract
date added to LUP
2015-08-06 22:45:05
date last changed
2017-01-01 04:16:42
@article{13bdf236-4ed4-49bc-81d9-6cfccc9c7f4e,
  abstract     = {Most approaches to arterial spin labelling (ASL) data analysis aim to provide a quantitative measure of the cerebral blood flow (CBF). This study, however, focuses on the measurement of the transfer time of blood water through the capillaries to the parenchyma (referred to as the capillary transfer time, CTT) as an alternative parameter to characterise the haemodynamics of the system. The method employed is based on a non-compartmental model, and no measurements need to be added to a common time-resolved ASL experiment. Brownian motion of labelled spins in a potential was described by a one-dimensional general Langevin equation as the starting point, and as a Fokker-Planck differential equation for the averaged distribution of labelled spins at the end point, which takes into account the effects of flow and dispersion of labelled water by the pseudorandom nature of the microvasculature and the transcapillary permeability. Multi-inversion time (multi-TI) ASL data were acquired in 14 healthy subjects on two occasions in a test-retest design, using a pulsed ASL sequence and three-dimensional gradient and spin echo (3D-GRASE) readout. Based on an error analysis to predict the size of a region of interest (ROI) required to obtain reasonably precise parameter estimates, data were analysed in two relatively large ROIs, i.e. the occipital lobe (OC) and the insular cortex (IC). The average values of CTT in OC were 260 ± 60 ms in the first experiment and 270 ± 60 ms in the second experiment. The corresponding IC values were 460 ± 130 ms and 420 ± 139 ms, respectively. Information related to the water transfer time may be important for diagnostics and follow-up of cerebral conditions or diseases characterised by a disrupted blood-brain barrier or disturbed capillary blood flow. Copyright © 2015 John Wiley & Sons, Ltd.},
  author       = {Bibic, Adnan and Knutsson, Linda and Schmidt, Anders and Henningsson, Erik and Månsson, Sven and Abul-Kasim, Kasim and Åkeson, Jonas and Gunther, Matthias and Ståhlberg, Freddy and Wirestam, Ronnie},
  issn         = {0952-3480},
  language     = {eng},
  number       = {8},
  pages        = {1059--1068},
  publisher    = {John Wiley & Sons},
  series       = {NMR in Biomedicine},
  title        = {Measurement of vascular water transport in human subjects using time-resolved pulsed arterial spin labelling.},
  url          = {http://dx.doi.org/10.1002/nbm.3344},
  volume       = {28},
  year         = {2015},
}