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HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma

Thuring, Camilla LU ; Follin, Elna LU ; Geironson Ulfsson, Linda LU ; Freyhult, Eva; Junghans, Victoria LU ; Harndahl, Mikkel; Buus, Søren and Paulsson, Kajsa M LU (2015) In British Journal of Cancer 113(6). p.952-962
Abstract
Tumour cells can evade the immune system by dysregulation of human leukocyte antigens (HLA-I). Low quantity and/or altered quality of HLA-I cell surface expression is the result of either HLA-I alterations or dysregulations of proteins of the antigen-processing machinery (APM). Tapasin is an APM protein dedicated to the maturation of HLA-I and dysregulation of tapasin has been linked to higher malignancy in several different tumours.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
HLA-I, tapasin, glioblastoma multiforme, peptide, tapasin-dependency, immunotherapy
in
British Journal of Cancer
volume
113
issue
6
pages
952 - 962
publisher
Nature Publishing Group
external identifiers
  • pmid:26313662
  • wos:000361499300012
  • scopus:84941877555
ISSN
1532-1827
DOI
10.1038/bjc.2015.297
language
English
LU publication?
yes
id
106eb7a5-c9ba-42cd-baaa-a403dbb8ca57 (old id 7794194)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26313662?dopt=Abstract
date added to LUP
2015-10-22 09:41:53
date last changed
2017-11-12 03:08:52
@article{106eb7a5-c9ba-42cd-baaa-a403dbb8ca57,
  abstract     = {Tumour cells can evade the immune system by dysregulation of human leukocyte antigens (HLA-I). Low quantity and/or altered quality of HLA-I cell surface expression is the result of either HLA-I alterations or dysregulations of proteins of the antigen-processing machinery (APM). Tapasin is an APM protein dedicated to the maturation of HLA-I and dysregulation of tapasin has been linked to higher malignancy in several different tumours.},
  author       = {Thuring, Camilla and Follin, Elna and Geironson Ulfsson, Linda and Freyhult, Eva and Junghans, Victoria and Harndahl, Mikkel and Buus, Søren and Paulsson, Kajsa M},
  issn         = {1532-1827},
  keyword      = {HLA-I,tapasin,glioblastoma multiforme,peptide,tapasin-dependency,immunotherapy},
  language     = {eng},
  number       = {6},
  pages        = {952--962},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma},
  url          = {http://dx.doi.org/10.1038/bjc.2015.297},
  volume       = {113},
  year         = {2015},
}