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The prognosis of breast cancer in males a report of 335 cases

Guinee, Vincent F. ; Shallenberger, Rick C. ; Olsson, Hakan LU orcid ; Moller, Torgil LU ; van den Blink, J. W. ; Peter, Zoltan ; Durand, Michel ; Dische, Stanley ; Cleton, Franz J. and Zewuster, Roelof , et al. (1993) In Cancer 71(1). p.154-161
Abstract

Background. Because of the relative rarity of breast cancer in males, data have not been sufficient to support a definitive analysis of pertinent prognostic factors. Remarkably, no studies of male patients with breast cancer have presented survival information based on the number of histologically positive axillary nodes, the most sensitive single indicator of prognosis in women with breast cancer. Methods. In this study, the clinical course of breast cancer was documented for 335 male patients registered from 1965 through 1986. For patients to be eligible, diagnoses had to be made within 3 months of registration and the patients had to have histologic confirmation and receive part or all of their initial treatment at 1 of 11 cancer... (More)

Background. Because of the relative rarity of breast cancer in males, data have not been sufficient to support a definitive analysis of pertinent prognostic factors. Remarkably, no studies of male patients with breast cancer have presented survival information based on the number of histologically positive axillary nodes, the most sensitive single indicator of prognosis in women with breast cancer. Methods. In this study, the clinical course of breast cancer was documented for 335 male patients registered from 1965 through 1986. For patients to be eligible, diagnoses had to be made within 3 months of registration and the patients had to have histologic confirmation and receive part or all of their initial treatment at 1 of 11 cancer centers participating in the International Patient Data Exchange System. Results. The survival rate at 10 years was 84% for patients with histologically negative nodes, 44% for those with one to three positive nodes, and 14% for the group with four or more histologically positive nodes. The survival rates at 5 years were 90%, 73%, and 55%, respectively. In a multivariable analysis, the risk of death due to breast cancer for a patient with four or more histologically positive nodes was 6.75 times that of a patient with negative nodes. Conclusions. The findings of the authors indicate the following: (1) The number of histologically positive axillary nodes and, to a lesser degree, tumor diameter are significant prognostic factors for breast cancer in male patients. (2) The prognosis of breast cancer is the same in male and female patients when compared on the basis of the number of histologically positive nodes. Cancer 1993; 71:154‐61.

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publishing date
type
Contribution to journal
publication status
published
keywords
axillary nodes, breast cancer male, multivariable analysis, prognosis, survival
in
Cancer
volume
71
issue
1
pages
154 - 161
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:0027524123
  • pmid:8416712
ISSN
0008-543X
DOI
10.1002/1097-0142(19930101)71:1<154::AID-CNCR2820710125>3.0.CO;2-%23
language
English
LU publication?
no
id
77d6954c-5163-4af6-bfbe-fba6fb310ceb
alternative location
https://onlinelibrary.wiley.com/doi/epdf/10.1002/1097-0142%2819930101%2971%3A1%3C154%3A%3Aaid-cncr2820710125%3E3.0.co%3B2-%23
date added to LUP
2019-05-28 16:18:14
date last changed
2024-05-29 12:44:42
@article{77d6954c-5163-4af6-bfbe-fba6fb310ceb,
  abstract     = {{<p>Background. Because of the relative rarity of breast cancer in males, data have not been sufficient to support a definitive analysis of pertinent prognostic factors. Remarkably, no studies of male patients with breast cancer have presented survival information based on the number of histologically positive axillary nodes, the most sensitive single indicator of prognosis in women with breast cancer. Methods. In this study, the clinical course of breast cancer was documented for 335 male patients registered from 1965 through 1986. For patients to be eligible, diagnoses had to be made within 3 months of registration and the patients had to have histologic confirmation and receive part or all of their initial treatment at 1 of 11 cancer centers participating in the International Patient Data Exchange System. Results. The survival rate at 10 years was 84% for patients with histologically negative nodes, 44% for those with one to three positive nodes, and 14% for the group with four or more histologically positive nodes. The survival rates at 5 years were 90%, 73%, and 55%, respectively. In a multivariable analysis, the risk of death due to breast cancer for a patient with four or more histologically positive nodes was 6.75 times that of a patient with negative nodes. Conclusions. The findings of the authors indicate the following: (1) The number of histologically positive axillary nodes and, to a lesser degree, tumor diameter are significant prognostic factors for breast cancer in male patients. (2) The prognosis of breast cancer is the same in male and female patients when compared on the basis of the number of histologically positive nodes. Cancer 1993; 71:154‐61.</p>}},
  author       = {{Guinee, Vincent F. and Shallenberger, Rick C. and Olsson, Hakan and Moller, Torgil and van den Blink, J. W. and Peter, Zoltan and Durand, Michel and Dische, Stanley and Cleton, Franz J. and Zewuster, Roelof and Cui, Mei Fang and Lane, Warren and Richter, Rudolf}},
  issn         = {{0008-543X}},
  keywords     = {{axillary nodes; breast cancer male; multivariable analysis; prognosis; survival}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{154--161}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Cancer}},
  title        = {{The prognosis of breast cancer in males a report of 335 cases}},
  url          = {{http://dx.doi.org/10.1002/1097-0142(19930101)71:1<154::AID-CNCR2820710125>3.0.CO;2-%23}},
  doi          = {{10.1002/1097-0142(19930101)71:1<154::AID-CNCR2820710125>3.0.CO;2-%23}},
  volume       = {{71}},
  year         = {{1993}},
}