Prevalence and functional impact of parkinsonian signs in older adults from the Good Aging in Skåne study : Parkinsonian signs in older adults
Algotsson, Charlotte LU ; Rosso, Aldana LU ; Elmståhl, Sölve LU and Siennicki-Lantz, Arkadiusz LU
(2023)
In Parkinsonism and Related Disorders
111.
p.1-7
- Abstract
- Introduction
Mild parkinsonian signs (MPS) have been characterized by several definitions, using the motor part of the Unified Parkinson's Disease Rating Scale (UPDRS). We aimed to investigate the prevalence of MPS and their association with functional level and comorbidities in the oldest old.
Method
Community-dwelling older adults (n = 559, median age 85, range 80–102 years) were examined regarding MPS, possible parkinsonism (PP) and subthreshold parkinsonism (SP) according to four previously used definitions and concerning the impact of parkinsonian signs on cognitive, physical, and autonomic function. MPS, PP and SP are different terms describing a very similar phenomenon and there is no gradation between these. In two... (More) - Introduction
Mild parkinsonian signs (MPS) have been characterized by several definitions, using the motor part of the Unified Parkinson's Disease Rating Scale (UPDRS). We aimed to investigate the prevalence of MPS and their association with functional level and comorbidities in the oldest old.
Method
Community-dwelling older adults (n = 559, median age 85, range 80–102 years) were examined regarding MPS, possible parkinsonism (PP) and subthreshold parkinsonism (SP) according to four previously used definitions and concerning the impact of parkinsonian signs on cognitive, physical, and autonomic function. MPS, PP and SP are different terms describing a very similar phenomenon and there is no gradation between these. In two of the four definitions more advanced symptoms were categorized as parkinsonism.
Results
Median UPDRS score in the whole study group was 10 points (range: 0–58) and was predominated by bradykinesia. MPS/PP/SP were present in 17–85%, and parkinsonism in 33–71% of the cohort. Independently of age and gender, MPS/PP/SP and especially parkinsonism, were associated with a higher risk of fear of falling and accomplished falls, with lower: cognition, ADL, physical activity and quality of life, and with urinary incontinence, obstipation and orthostatic intolerance.
Conclusions
In a population of older adults above 80 years, MPS are highly prevalent as well as more advanced symptoms defined as parkinsonism, and only 9–17% of the cohort is symptom-free. Predominance of bradykinesia in the oldest old might indicate a need for revision of MPS definitions to improve their sensibility. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/77e898f2-5eaf-4889-9fe0-7ab174904817
- author
- Algotsson, Charlotte
LU
; Rosso, Aldana
LU
; Elmståhl, Sölve
LU
and Siennicki-Lantz, Arkadiusz
LU
- organization
- publishing date
- 2023-06
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Parkinsonism and Related Disorders
- volume
- 111
- article number
- 105416
- pages
- 1 - 7
- publisher
- Elsevier
- external identifiers
-
- pmid:37130449
- scopus:85154593852
- ISSN
- 1873-5126
- DOI
- 10.1016/j.parkreldis.2023.105416
- language
- English
- LU publication?
- yes
- id
- 77e898f2-5eaf-4889-9fe0-7ab174904817
- date added to LUP
- 2023-04-30 20:30:28
- date last changed
- 2023-08-07 09:17:02
@article{77e898f2-5eaf-4889-9fe0-7ab174904817,
abstract = {{Introduction<br/>Mild parkinsonian signs (MPS) have been characterized by several definitions, using the motor part of the Unified Parkinson's Disease Rating Scale (UPDRS). We aimed to investigate the prevalence of MPS and their association with functional level and comorbidities in the oldest old.<br/><br/>Method<br/>Community-dwelling older adults (n = 559, median age 85, range 80–102 years) were examined regarding MPS, possible parkinsonism (PP) and subthreshold parkinsonism (SP) according to four previously used definitions and concerning the impact of parkinsonian signs on cognitive, physical, and autonomic function. MPS, PP and SP are different terms describing a very similar phenomenon and there is no gradation between these. In two of the four definitions more advanced symptoms were categorized as parkinsonism.<br/><br/>Results<br/>Median UPDRS score in the whole study group was 10 points (range: 0–58) and was predominated by bradykinesia. MPS/PP/SP were present in 17–85%, and parkinsonism in 33–71% of the cohort. Independently of age and gender, MPS/PP/SP and especially parkinsonism, were associated with a higher risk of fear of falling and accomplished falls, with lower: cognition, ADL, physical activity and quality of life, and with urinary incontinence, obstipation and orthostatic intolerance.<br/><br/>Conclusions<br/>In a population of older adults above 80 years, MPS are highly prevalent as well as more advanced symptoms defined as parkinsonism, and only 9–17% of the cohort is symptom-free. Predominance of bradykinesia in the oldest old might indicate a need for revision of MPS definitions to improve their sensibility.}},
author = {{Algotsson, Charlotte and Rosso, Aldana and Elmståhl, Sölve and Siennicki-Lantz, Arkadiusz}},
issn = {{1873-5126}},
language = {{eng}},
pages = {{1--7}},
publisher = {{Elsevier}},
series = {{Parkinsonism and Related Disorders}},
title = {{Prevalence and functional impact of parkinsonian signs in older adults from the Good Aging in Skåne study : Parkinsonian signs in older adults}},
url = {{http://dx.doi.org/10.1016/j.parkreldis.2023.105416}},
doi = {{10.1016/j.parkreldis.2023.105416}},
volume = {{111}},
year = {{2023}},
}