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The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.

Fritz, Helena LU ; Gustafsson, Anna LU ; Ljungberg, Börje; Ceder, Yvonne LU ; Axelson, Håkan LU and Dahlbäck, Björn LU (2015) In PLoS ONE 10(8).
Abstract
High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
10
issue
8
publisher
Public Library of Science
external identifiers
  • pmid:26287733
  • wos:000360018600095
  • scopus:84942474892
ISSN
1932-6203
DOI
10.1371/journal.pone.0135991
language
English
LU publication?
yes
id
73026e14-a2f7-4b5d-a1c8-7fc126ec708c (old id 7840581)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26287733?dopt=Abstract
date added to LUP
2015-09-06 15:20:10
date last changed
2017-07-09 04:00:55
@article{73026e14-a2f7-4b5d-a1c8-7fc126ec708c,
  abstract     = {High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.},
  articleno    = {e0135991},
  author       = {Fritz, Helena and Gustafsson, Anna and Ljungberg, Börje and Ceder, Yvonne and Axelson, Håkan and Dahlbäck, Björn},
  issn         = {1932-6203},
  language     = {eng},
  number       = {8},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0135991},
  volume       = {10},
  year         = {2015},
}