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Harmful somatic amino acid substitutions affect key pathways in cancers.

Niroula, Abhishek LU and Vihinen, Mauno LU (2015) In BMC Medical Genomics 8(1).
Abstract
Cancer is characterized by the accumulation of large numbers of genetic variations and alterations of multiple biological phenomena. Cancer genomics has largely focused on the identification of such genetic alterations and the genes containing them, known as 'cancer genes'. However, the non-functional somatic variations out-number functional variations and remain as a major challenge. Recurrent somatic variations are thought to be cancer drivers but they are present in only a small fraction of patients.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Medical Genomics
volume
8
issue
1
publisher
BioMed Central
external identifiers
  • wos:000359979900001
  • pmid:26282678
  • scopus:84939235946
ISSN
1755-8794
DOI
10.1186/s12920-015-0125-x
language
English
LU publication?
yes
id
4f763f26-2b92-4175-b9f7-0d81d4ed8a4b (old id 7840723)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26282678?dopt=Abstract
date added to LUP
2015-09-06 14:26:46
date last changed
2017-08-27 04:33:30
@article{4f763f26-2b92-4175-b9f7-0d81d4ed8a4b,
  abstract     = {Cancer is characterized by the accumulation of large numbers of genetic variations and alterations of multiple biological phenomena. Cancer genomics has largely focused on the identification of such genetic alterations and the genes containing them, known as 'cancer genes'. However, the non-functional somatic variations out-number functional variations and remain as a major challenge. Recurrent somatic variations are thought to be cancer drivers but they are present in only a small fraction of patients.},
  articleno    = {53},
  author       = {Niroula, Abhishek and Vihinen, Mauno},
  issn         = {1755-8794},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {BMC Medical Genomics},
  title        = {Harmful somatic amino acid substitutions affect key pathways in cancers.},
  url          = {http://dx.doi.org/10.1186/s12920-015-0125-x},
  volume       = {8},
  year         = {2015},
}