Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma
Hu, Dingyuan LU ; Ansari, Daniel LU ; Zhou, Qimin LU
; Sasor, Agata
LU
; Said Hilmersson, Katarzyna
LU
and Andersson, Roland
LU
(2019)
In World Journal of Surgical Oncology
17(1).
- Abstract
Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense stroma, which has a fundamental role in tumor progression. Fibronectin (FN1) is the main constituent of the tumor stroma in pancreatic cancer. This study aimed to explore the association between FN1 and clinicopathological characteristics and disease survival. Methods: Formalin-fixed paraffin-embedded tissue samples from 138 patients with PDAC were constructed into a tissue microarray, followed by immunohistochemical analysis with a recombinant monoclonal FN1 antibody. Chi-square test or Fisher's exact test were used for comparison of FN1 expression and relevant clinicopathological parameters. Kaplan-Meier survival curves and Cox regression... (More)
Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense stroma, which has a fundamental role in tumor progression. Fibronectin (FN1) is the main constituent of the tumor stroma in pancreatic cancer. This study aimed to explore the association between FN1 and clinicopathological characteristics and disease survival. Methods: Formalin-fixed paraffin-embedded tissue samples from 138 patients with PDAC were constructed into a tissue microarray, followed by immunohistochemical analysis with a recombinant monoclonal FN1 antibody. Chi-square test or Fisher's exact test were used for comparison of FN1 expression and relevant clinicopathological parameters. Kaplan-Meier survival curves and Cox regression analyses were used to assess the association between FN1 and survival. Results: FN1 was detected in the stromal compartment in most cases (117/138, 84.8%). Compared to the low FN1 expression group, the high FN1 expression group had significantly larger tumor size (P = 0.002), more advanced T stage (P = 0.039) and N stage (P = 0.009), and also worse AJCC stage (P = 0.003). However, stromal FN1 expression was not associated with disease-free survival or overall survival. Conclusions: This study suggests that high stromal FN1 expression is associated with aggressive tumor characteristics in patients with resected PDAC. However, no association between FN1 expression and survival was found.
(Less)
- author
- Hu, Dingyuan
LU
; Ansari, Daniel
LU
; Zhou, Qimin
LU
; Sasor, Agata
LU
; Said Hilmersson, Katarzyna
LU
and Andersson, Roland
LU
- organization
- publishing date
- 2019-02-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Fibronectin, Immunohistochemistry, Pancreatic ductal adenocarcinoma, Survival
- in
- World Journal of Surgical Oncology
- volume
- 17
- issue
- 1
- article number
- 29
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85061278622
- pmid:30736807
- ISSN
- 1477-7819
- DOI
- 10.1186/s12957-019-1574-z
- language
- English
- LU publication?
- yes
- id
- 786401dd-0807-488b-9376-751d87613251
- date added to LUP
- 2019-02-19 07:40:29
- date last changed
- 2024-04-01 22:09:40
@article{786401dd-0807-488b-9376-751d87613251,
abstract = {{<p>Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense stroma, which has a fundamental role in tumor progression. Fibronectin (FN1) is the main constituent of the tumor stroma in pancreatic cancer. This study aimed to explore the association between FN1 and clinicopathological characteristics and disease survival. Methods: Formalin-fixed paraffin-embedded tissue samples from 138 patients with PDAC were constructed into a tissue microarray, followed by immunohistochemical analysis with a recombinant monoclonal FN1 antibody. Chi-square test or Fisher's exact test were used for comparison of FN1 expression and relevant clinicopathological parameters. Kaplan-Meier survival curves and Cox regression analyses were used to assess the association between FN1 and survival. Results: FN1 was detected in the stromal compartment in most cases (117/138, 84.8%). Compared to the low FN1 expression group, the high FN1 expression group had significantly larger tumor size (P = 0.002), more advanced T stage (P = 0.039) and N stage (P = 0.009), and also worse AJCC stage (P = 0.003). However, stromal FN1 expression was not associated with disease-free survival or overall survival. Conclusions: This study suggests that high stromal FN1 expression is associated with aggressive tumor characteristics in patients with resected PDAC. However, no association between FN1 expression and survival was found.</p>}},
author = {{Hu, Dingyuan and Ansari, Daniel and Zhou, Qimin and Sasor, Agata and Said Hilmersson, Katarzyna and Andersson, Roland}},
issn = {{1477-7819}},
keywords = {{Fibronectin; Immunohistochemistry; Pancreatic ductal adenocarcinoma; Survival}},
language = {{eng}},
month = {{02}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{World Journal of Surgical Oncology}},
title = {{Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma}},
url = {{http://dx.doi.org/10.1186/s12957-019-1574-z}},
doi = {{10.1186/s12957-019-1574-z}},
volume = {{17}},
year = {{2019}},
}