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Bioaccessibility and bioavailability of environmental semi-volatile organic compounds via inhalation : A review of methods and models

Wei, Wenjuan; Bonvallot, Nathalie; Gustafsson, Åsa; Raffy, Gaëlle; Glorennec, Philippe; Krais, Annette LU ; Ramalho, Olivier; Le Bot, Barbara and Mandin, Corinne (2018) In Environment International 113. p.202-213
Abstract

Semi-volatile organic compounds (SVOCs) present in indoor environments are known to cause adverse health effects through multiple routes of exposure. To assess the aggregate exposure, the bioaccessibility and bioavailability of SVOCs need to be determined. In this review, we discussed measurements of the bioaccessibility and bioavailability of SVOCs after inhalation. Published literature related to this issue is available for 2,3,7,8-tetrachlorodibenzo-p-dioxin and a few polycyclic aromatic hydrocarbons, such as benzo[a]pyrene and phenanthrene. Then, we reviewed common modeling approaches for the characterization of the gas- and particle-phase partitioning of SVOCs during inhalation. The models are based on mass transfer mechanisms as... (More)

Semi-volatile organic compounds (SVOCs) present in indoor environments are known to cause adverse health effects through multiple routes of exposure. To assess the aggregate exposure, the bioaccessibility and bioavailability of SVOCs need to be determined. In this review, we discussed measurements of the bioaccessibility and bioavailability of SVOCs after inhalation. Published literature related to this issue is available for 2,3,7,8-tetrachlorodibenzo-p-dioxin and a few polycyclic aromatic hydrocarbons, such as benzo[a]pyrene and phenanthrene. Then, we reviewed common modeling approaches for the characterization of the gas- and particle-phase partitioning of SVOCs during inhalation. The models are based on mass transfer mechanisms as well as the structure of the respiratory system, using common computational techniques, such as computational fluid dynamics. However, the existing models are restricted to special conditions and cannot predict SVOC bioaccessibility and bioavailability in the whole respiratory system. The present review notes two main challenges for the estimation of SVOC bioaccessibility and bioavailability via inhalation in humans. First, in vitro and in vivo methods need to be developed and validated for a wide range of SVOCs. The in vitro methods should be validated with in vivo tests to evaluate human exposures to SVOCs in airborne particles. Second, modeling approaches for SVOCs need to consider the whole respiratory system. Alterations of the respiratory cycle period and human biological variability may be considered in future studies.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Absorption, Deposition, Inhalation exposure, Internal dose, Respiratory tract, SVOCs
in
Environment International
volume
113
pages
12 pages
publisher
Elsevier
external identifiers
  • scopus:85041804415
ISSN
0160-4120
DOI
10.1016/j.envint.2018.01.024
language
English
LU publication?
yes
id
797bee1e-33f2-4060-9a4e-3e3cef8a399f
date added to LUP
2018-02-20 11:56:49
date last changed
2018-06-03 05:04:57
@article{797bee1e-33f2-4060-9a4e-3e3cef8a399f,
  abstract     = {<p>Semi-volatile organic compounds (SVOCs) present in indoor environments are known to cause adverse health effects through multiple routes of exposure. To assess the aggregate exposure, the bioaccessibility and bioavailability of SVOCs need to be determined. In this review, we discussed measurements of the bioaccessibility and bioavailability of SVOCs after inhalation. Published literature related to this issue is available for 2,3,7,8-tetrachlorodibenzo-p-dioxin and a few polycyclic aromatic hydrocarbons, such as benzo[a]pyrene and phenanthrene. Then, we reviewed common modeling approaches for the characterization of the gas- and particle-phase partitioning of SVOCs during inhalation. The models are based on mass transfer mechanisms as well as the structure of the respiratory system, using common computational techniques, such as computational fluid dynamics. However, the existing models are restricted to special conditions and cannot predict SVOC bioaccessibility and bioavailability in the whole respiratory system. The present review notes two main challenges for the estimation of SVOC bioaccessibility and bioavailability via inhalation in humans. First, in vitro and in vivo methods need to be developed and validated for a wide range of SVOCs. The in vitro methods should be validated with in vivo tests to evaluate human exposures to SVOCs in airborne particles. Second, modeling approaches for SVOCs need to consider the whole respiratory system. Alterations of the respiratory cycle period and human biological variability may be considered in future studies.</p>},
  author       = {Wei, Wenjuan and Bonvallot, Nathalie and Gustafsson, Åsa and Raffy, Gaëlle and Glorennec, Philippe and Krais, Annette and Ramalho, Olivier and Le Bot, Barbara and Mandin, Corinne},
  issn         = {0160-4120},
  keyword      = {Absorption,Deposition,Inhalation exposure,Internal dose,Respiratory tract,SVOCs},
  language     = {eng},
  month        = {04},
  pages        = {202--213},
  publisher    = {Elsevier},
  series       = {Environment International},
  title        = {Bioaccessibility and bioavailability of environmental semi-volatile organic compounds via inhalation : A review of methods and models},
  url          = {http://dx.doi.org/10.1016/j.envint.2018.01.024},
  volume       = {113},
  year         = {2018},
}