Month of birth and the risk of developing type 1 diabetes among children in the Swedish national Better Diabetes Diagnosis Study
Hedlund, Emma LU ; Ludvigsson, Johnny ; Elding Larsson, Helena LU ; Forsander, Gun ; Ivarsson, Sten LU ; Marcus, Claude ; Samuelsson, Ulf ; Persson, Martina and Carlsson, Annelie LU
(2022)
In Acta Paediatrica, International Journal of Paediatrics
111(12).
p.2378-2383
- Abstract
Aim: Previous studies have reported an association between month of birth and incidence of type 1 diabetes. Using population-based data, including almost all newly diagnosed children with type 1 diabetes in Sweden, we tested whether month of birth influences the risk of type 1 diabetes. Methods: For 8761 children diagnosed with type 1 diabetes between May 2005 and December 2016 in the Better Diabetes Diagnosis study, month of birth, sex and age were compared. Human leucocyte antigen (HLA) genotype and autoantibodies at diagnosis were analysed for a subset of the cohort (n = 3647). Comparisons with the general population used data from Statistics Sweden. Results: We found no association between month of birth or season and the incidence... (More)
Aim: Previous studies have reported an association between month of birth and incidence of type 1 diabetes. Using population-based data, including almost all newly diagnosed children with type 1 diabetes in Sweden, we tested whether month of birth influences the risk of type 1 diabetes. Methods: For 8761 children diagnosed with type 1 diabetes between May 2005 and December 2016 in the Better Diabetes Diagnosis study, month of birth, sex and age were compared. Human leucocyte antigen (HLA) genotype and autoantibodies at diagnosis were analysed for a subset of the cohort (n = 3647). Comparisons with the general population used data from Statistics Sweden. Results: We found no association between month of birth or season and the incidence of type 1 diabetes in the cohort as a whole. However, boys diagnosed before 5 years were more often born in May (p = 0.004). We found no correlation between month of birth and HLA or antibodies. Conclusion: In this large nationwide study, the impact of month of birth on type 1 diabetes diagnosis was weak, except for boys diagnosed before 5 years of age, who were more likely born in May. This may suggest different triggers for different subgroups of patients with type 1 diabetes.
(Less)
- author
- Hedlund, Emma
LU
; Ludvigsson, Johnny
; Elding Larsson, Helena
LU
; Forsander, Gun
; Ivarsson, Sten
LU
; Marcus, Claude
; Samuelsson, Ulf
; Persson, Martina
and Carlsson, Annelie
LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- autoantibodies, birth pattern, HLA-DQ alleles, seasonality, type 1 diabetes
- in
- Acta Paediatrica, International Journal of Paediatrics
- volume
- 111
- issue
- 12
- pages
- 2378 - 2383
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:35615774
- scopus:85131510831
- ISSN
- 0803-5253
- DOI
- 10.1111/apa.16426
- project
- Better Diabetes Diagnosis (BDD)
- language
- English
- LU publication?
- yes
- id
- 79a4583c-a3a9-4cf9-9821-96ef9b76afbd
- date added to LUP
- 2022-08-22 12:05:47
- date last changed
- 2024-06-13 18:23:10
@article{79a4583c-a3a9-4cf9-9821-96ef9b76afbd,
abstract = {{<p>Aim: Previous studies have reported an association between month of birth and incidence of type 1 diabetes. Using population-based data, including almost all newly diagnosed children with type 1 diabetes in Sweden, we tested whether month of birth influences the risk of type 1 diabetes. Methods: For 8761 children diagnosed with type 1 diabetes between May 2005 and December 2016 in the Better Diabetes Diagnosis study, month of birth, sex and age were compared. Human leucocyte antigen (HLA) genotype and autoantibodies at diagnosis were analysed for a subset of the cohort (n = 3647). Comparisons with the general population used data from Statistics Sweden. Results: We found no association between month of birth or season and the incidence of type 1 diabetes in the cohort as a whole. However, boys diagnosed before 5 years were more often born in May (p = 0.004). We found no correlation between month of birth and HLA or antibodies. Conclusion: In this large nationwide study, the impact of month of birth on type 1 diabetes diagnosis was weak, except for boys diagnosed before 5 years of age, who were more likely born in May. This may suggest different triggers for different subgroups of patients with type 1 diabetes.</p>}},
author = {{Hedlund, Emma and Ludvigsson, Johnny and Elding Larsson, Helena and Forsander, Gun and Ivarsson, Sten and Marcus, Claude and Samuelsson, Ulf and Persson, Martina and Carlsson, Annelie}},
issn = {{0803-5253}},
keywords = {{autoantibodies; birth pattern; HLA-DQ alleles; seasonality; type 1 diabetes}},
language = {{eng}},
number = {{12}},
pages = {{2378--2383}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Paediatrica, International Journal of Paediatrics}},
title = {{Month of birth and the risk of developing type 1 diabetes among children in the Swedish national Better Diabetes Diagnosis Study}},
url = {{http://dx.doi.org/10.1111/apa.16426}},
doi = {{10.1111/apa.16426}},
volume = {{111}},
year = {{2022}},
}