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Dacrymenone and VM 3298-2 - New antibiotics with antibacterial and antifungal activity

Mierau, V ; Anke, T and Sterner, Olov LU (2003) In Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences 58(7-8). p.541-546
Abstract
Two new antibiotic metabolites, dacrymenone (1) and VM 3298-2 (2), were isolated from fermentations of a Dacrymyces sp., and their structures were determined by spectroscopic techniques. Dacrymenone (1) is a new eremophilane sesquiterpenoid while VM 3298-2 (2) is a bis-enol ether between methyl pyruvate and 4,6-dihydroxycyclohexan-1,3-dione. Dacrymenone (1) shows weak antibacterial and antifungal activity while VM 3298-2 (2) exhibits cytotoxic and antifungal activities.
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antifungal antibiotic, eremophilanes, Dacrymyces
in
Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
volume
58
issue
7-8
pages
541 - 546
publisher
Verlag der Zeitschrift für Naturforschung
external identifiers
  • wos:000185144500016
  • scopus:0041655935
ISSN
0939-5075
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
79c8a573-b467-41d7-8e67-9391fad9747e (old id 301538)
alternative location
http://www.znaturforsch.com/ac/v58c/s58c0541.pdf
date added to LUP
2016-04-01 16:07:53
date last changed
2022-01-28 17:28:15
@article{79c8a573-b467-41d7-8e67-9391fad9747e,
  abstract     = {{Two new antibiotic metabolites, dacrymenone (1) and VM 3298-2 (2), were isolated from fermentations of a Dacrymyces sp., and their structures were determined by spectroscopic techniques. Dacrymenone (1) is a new eremophilane sesquiterpenoid while VM 3298-2 (2) is a bis-enol ether between methyl pyruvate and 4,6-dihydroxycyclohexan-1,3-dione. Dacrymenone (1) shows weak antibacterial and antifungal activity while VM 3298-2 (2) exhibits cytotoxic and antifungal activities.}},
  author       = {{Mierau, V and Anke, T and Sterner, Olov}},
  issn         = {{0939-5075}},
  keywords     = {{antifungal antibiotic; eremophilanes; Dacrymyces}},
  language     = {{eng}},
  number       = {{7-8}},
  pages        = {{541--546}},
  publisher    = {{Verlag der Zeitschrift für Naturforschung}},
  series       = {{Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences}},
  title        = {{Dacrymenone and VM 3298-2 - New antibiotics with antibacterial and antifungal activity}},
  url          = {{http://www.znaturforsch.com/ac/v58c/s58c0541.pdf}},
  volume       = {{58}},
  year         = {{2003}},
}