Risk of Adverse Outcomes Associated With Cardiac Sarcoidosis Diagnostic Schemes
(2023) In JACC: Clinical Electrophysiology 9(8). p.1719-1729- Abstract
Background: Multiple cardiac sarcoidosis (CS) diagnostic schemes have been published. Objectives: This study aims to evaluate the association of different CS diagnostic schemes with adverse outcomes. The diagnostic schemes evaluated were 1993, 2006, and 2017 Japanese criteria and the 2014 Heart Rhythm Society criteria. Methods: Data were collected from the Cardiac Sarcoidosis Consortium, an international registry of CS patients. Outcome events were any of the following: all-cause mortality, left ventricular assist device placement, heart transplantation, and appropriate implantable cardioverter-defibrillator therapy. Logistic regression analysis evaluated the association of outcomes with each CS diagnostic scheme. Results: A total of... (More)
Background: Multiple cardiac sarcoidosis (CS) diagnostic schemes have been published. Objectives: This study aims to evaluate the association of different CS diagnostic schemes with adverse outcomes. The diagnostic schemes evaluated were 1993, 2006, and 2017 Japanese criteria and the 2014 Heart Rhythm Society criteria. Methods: Data were collected from the Cardiac Sarcoidosis Consortium, an international registry of CS patients. Outcome events were any of the following: all-cause mortality, left ventricular assist device placement, heart transplantation, and appropriate implantable cardioverter-defibrillator therapy. Logistic regression analysis evaluated the association of outcomes with each CS diagnostic scheme. Results: A total of 587 subjects met the following criteria: 1993 Japanese (n = 310, 52.8%), 2006 Japanese (n = 312, 53.2%), 2014 Heart Rhythm Society (n = 480, 81.8%), and 2017 Japanese (n = 112, 19.1%). Patients who met the 1993 criteria were more likely to experience an event than patients who did not (n = 109 of 310, 35.2% vs n = 59 of 277, 21.3%; OR: 2.00; 95% CI: 1.38-2.90; P < 0.001). Similarly, patients who met the 2006 criteria were more likely to have an event than patients who did not (n = 116 of 312, 37.2% vs n = 52 of 275, 18.9%; OR: 2.54; 95% CI: 1.74-3.71; P < 0.001). There was no statistically significant association between the occurrence of an event and whether a patient met the 2014 or the 2017 criteria (OR: 1.39; 95% CI: 0.85-2.27; P = 0.18 or OR: 1.51; 95% CI: 0.97-2.33; P = 0.067, respectively). Conclusions: CS patients who met the 1993 and the 2006 criteria had higher odds of adverse clinical outcomes. Future research is needed to prospectively evaluate existing diagnostic schemes and develop new risk models for this complex disease.
(Less)
- author
- author collaboration
- organization
- publishing date
- 2023-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cardiac sarcoidosis, cardiac sarcoidosis consortium, diagnostic criteria, risk assessment
- in
- JACC: Clinical Electrophysiology
- volume
- 9
- issue
- 8
- pages
- 11 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:37227359
- scopus:85168154984
- ISSN
- 2405-500X
- DOI
- 10.1016/j.jacep.2023.04.010
- language
- English
- LU publication?
- yes
- id
- 79e36f23-7b2d-4583-9224-a974606046de
- date added to LUP
- 2023-10-31 14:45:56
- date last changed
- 2024-04-19 03:12:41
@article{79e36f23-7b2d-4583-9224-a974606046de,
abstract = {{<p>Background: Multiple cardiac sarcoidosis (CS) diagnostic schemes have been published. Objectives: This study aims to evaluate the association of different CS diagnostic schemes with adverse outcomes. The diagnostic schemes evaluated were 1993, 2006, and 2017 Japanese criteria and the 2014 Heart Rhythm Society criteria. Methods: Data were collected from the Cardiac Sarcoidosis Consortium, an international registry of CS patients. Outcome events were any of the following: all-cause mortality, left ventricular assist device placement, heart transplantation, and appropriate implantable cardioverter-defibrillator therapy. Logistic regression analysis evaluated the association of outcomes with each CS diagnostic scheme. Results: A total of 587 subjects met the following criteria: 1993 Japanese (n = 310, 52.8%), 2006 Japanese (n = 312, 53.2%), 2014 Heart Rhythm Society (n = 480, 81.8%), and 2017 Japanese (n = 112, 19.1%). Patients who met the 1993 criteria were more likely to experience an event than patients who did not (n = 109 of 310, 35.2% vs n = 59 of 277, 21.3%; OR: 2.00; 95% CI: 1.38-2.90; P < 0.001). Similarly, patients who met the 2006 criteria were more likely to have an event than patients who did not (n = 116 of 312, 37.2% vs n = 52 of 275, 18.9%; OR: 2.54; 95% CI: 1.74-3.71; P < 0.001). There was no statistically significant association between the occurrence of an event and whether a patient met the 2014 or the 2017 criteria (OR: 1.39; 95% CI: 0.85-2.27; P = 0.18 or OR: 1.51; 95% CI: 0.97-2.33; P = 0.067, respectively). Conclusions: CS patients who met the 1993 and the 2006 criteria had higher odds of adverse clinical outcomes. Future research is needed to prospectively evaluate existing diagnostic schemes and develop new risk models for this complex disease.</p>}},
author = {{Myadam, Rahul and Crawford, Thomas C. and Bogun, Frank M. and Gu, Xiaokui and Ellenbogen, Kenneth A. and Jasti, Shilpa and Chicos, Alexandru B. and Roukoz, Henri and Zimetbaum, Peter J. and Kalbfleisch, Steven J. and Murgatroyd, Francis D. and Steckman, David A. and Rosenfeld, Lynda E. and Garlitski, Ann C. and Soejima, Kyoko and Bhan, Adarsh K. and Vedantham, Vasanth and Dickfeld, Timm Michael L. and De Lurgio, David B. and Platonov, Pyotr G. and Zipse, Matthew M. and Nishiuchi, Suguru and Ortman, Matthew L. and Narasimhan, Calambur and Patton, Kristen K. and Rosenthal, David G. and Mukerji, Siddharth S. and Hoogendoorn, Jarieke C. and Zeppenfeld, Katja and Sauer, William H. and Kron, Jordana}},
issn = {{2405-500X}},
keywords = {{cardiac sarcoidosis; cardiac sarcoidosis consortium; diagnostic criteria; risk assessment}},
language = {{eng}},
number = {{8}},
pages = {{1719--1729}},
publisher = {{Elsevier}},
series = {{JACC: Clinical Electrophysiology}},
title = {{Risk of Adverse Outcomes Associated With Cardiac Sarcoidosis Diagnostic Schemes}},
url = {{http://dx.doi.org/10.1016/j.jacep.2023.04.010}},
doi = {{10.1016/j.jacep.2023.04.010}},
volume = {{9}},
year = {{2023}},
}