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Replacing Dopamine Neurons in Parkinson's Disease : How did it happen?

Björklund, Anders LU and Lindvall, Olle LU (2017) In Journal of Parkinson's Disease 7(s1). p.23-33
Abstract

The efforts to develop a dopamine cell replacement therapy for Parkinson's disease have spanned over more than three decades. Based on almost 10 years of transplantation studies in animal models, the first patients receiving grafts of fetal-derived dopamine neuroblasts were operated in Lund in 1987. Over the following two decades, a total of 18 patients were transplanted and followed closely by our team with mixed but also very encouraging results. In this article we tell the story of how the preclinical and clinical transplantation program in Lund evolved. We recall the excitement when we obtained the first evidence for survival and function of transplanted neurons in the diseased human brain. We also remember the setbacks that we have... (More)

The efforts to develop a dopamine cell replacement therapy for Parkinson's disease have spanned over more than three decades. Based on almost 10 years of transplantation studies in animal models, the first patients receiving grafts of fetal-derived dopamine neuroblasts were operated in Lund in 1987. Over the following two decades, a total of 18 patients were transplanted and followed closely by our team with mixed but also very encouraging results. In this article we tell the story of how the preclinical and clinical transplantation program in Lund evolved. We recall the excitement when we obtained the first evidence for survival and function of transplanted neurons in the diseased human brain. We also remember the setbacks that we have experienced during these 30 years and discuss the very interesting developments that are now taking place in this exciting field.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
brain repair, fetal tissue, stem cells, Transplantation
in
Journal of Parkinson's Disease
volume
7
issue
s1
pages
23 - 33
publisher
IOS Press
external identifiers
  • scopus:85015220842
  • wos:000396271800004
ISSN
1877-7171
DOI
10.3233/JPD-179002
language
English
LU publication?
yes
id
7a0ac5a0-80c5-4c26-ab35-950a8388de98
alternative location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345652/
date added to LUP
2017-04-07 10:33:42
date last changed
2017-09-18 13:31:44
@article{7a0ac5a0-80c5-4c26-ab35-950a8388de98,
  abstract     = {<p>The efforts to develop a dopamine cell replacement therapy for Parkinson's disease have spanned over more than three decades. Based on almost 10 years of transplantation studies in animal models, the first patients receiving grafts of fetal-derived dopamine neuroblasts were operated in Lund in 1987. Over the following two decades, a total of 18 patients were transplanted and followed closely by our team with mixed but also very encouraging results. In this article we tell the story of how the preclinical and clinical transplantation program in Lund evolved. We recall the excitement when we obtained the first evidence for survival and function of transplanted neurons in the diseased human brain. We also remember the setbacks that we have experienced during these 30 years and discuss the very interesting developments that are now taking place in this exciting field.</p>},
  author       = {Björklund, Anders and Lindvall, Olle},
  issn         = {1877-7171},
  keyword      = {brain repair,fetal tissue,stem cells,Transplantation},
  language     = {eng},
  number       = {s1},
  pages        = {23--33},
  publisher    = {IOS Press},
  series       = {Journal of Parkinson's Disease},
  title        = {Replacing Dopamine Neurons in Parkinson's Disease : How did it happen?},
  url          = {http://dx.doi.org/10.3233/JPD-179002},
  volume       = {7},
  year         = {2017},
}