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Low rate of lymphedema after extended pelvic lymphadenectomy followed by pelvic irradiation of node-positive prostate cancer

Rasmusson, Elisabeth LU ; Gunnlaugsson, Adalsteinn LU ; Blom, René LU ; Bojrk-Eriksson, Thomas ; Nilsson, Per LU ; Ahlgren, Göran LU ; Jönsson, Charlotta ; Johansson, Karin LU and Kjellén, Elisabeth LU (2013) In Radiation Oncology 8.
Abstract
Background: The aim of the present study was to evaluate the prevalence and severity of lower limb lymphedema after pelvic lymphadenectomy and radiotherapy to the pelvic lymph nodes in patients with prostate cancer. Methods: Twenty-six patients underwent combined treatment for high-risk node-positive prostate cancer at Skane University Hospital between April 2008 and March 2011. The treatment consisted of extended pelvic lymphadenectomy followed by androgen deprivation therapy and radiotherapy. The pelvic lymphnodes, prostate and seminal vesicles were treated with external beam radiotherapy (EBRT) to an absorbed dose of 50 Gy followed by a brachytherapy (BT) boost of 2x10 Gy to the prostate only. Twenty-two patients accepted an invitation... (More)
Background: The aim of the present study was to evaluate the prevalence and severity of lower limb lymphedema after pelvic lymphadenectomy and radiotherapy to the pelvic lymph nodes in patients with prostate cancer. Methods: Twenty-six patients underwent combined treatment for high-risk node-positive prostate cancer at Skane University Hospital between April 2008 and March 2011. The treatment consisted of extended pelvic lymphadenectomy followed by androgen deprivation therapy and radiotherapy. The pelvic lymphnodes, prostate and seminal vesicles were treated with external beam radiotherapy (EBRT) to an absorbed dose of 50 Gy followed by a brachytherapy (BT) boost of 2x10 Gy to the prostate only. Twenty-two patients accepted an invitation to a clinical examination with focus on lower limb swelling. The median time between the end of radiotherapy and examination was 2.2 years (range 1.2-4.1). Results: Six patients (27%) experienced grade 1 lymphedema and two patients (9%) grade 2 while none had grade 3 or 4 according to the CTC Common Toxicity Criteria scale 4.0. Three patients required treatment with compression stockings. Conclusion: Brachytherapy and pelvic EBRT have a low incidence of lymphedema (at median 2.2 y after treatment) in patients with high-risk node-positive prostate cancer that have undergone pelvic lymph node dissection. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Prostate cancer, Lymphadenectomy, Pelvic irradiation, Node-positive, Lymphedema
in
Radiation Oncology
volume
8
article number
271
publisher
BioMed Central (BMC)
external identifiers
  • wos:000327741300001
  • scopus:84887686443
  • pmid:24252686
ISSN
1748-717X
DOI
10.1186/1748-717X-8-271
language
English
LU publication?
yes
id
7a6605e4-55d5-43d1-be88-eff18c638486 (old id 4273144)
date added to LUP
2016-04-01 13:54:42
date last changed
2021-01-26 03:07:01
@article{7a6605e4-55d5-43d1-be88-eff18c638486,
  abstract     = {Background: The aim of the present study was to evaluate the prevalence and severity of lower limb lymphedema after pelvic lymphadenectomy and radiotherapy to the pelvic lymph nodes in patients with prostate cancer. Methods: Twenty-six patients underwent combined treatment for high-risk node-positive prostate cancer at Skane University Hospital between April 2008 and March 2011. The treatment consisted of extended pelvic lymphadenectomy followed by androgen deprivation therapy and radiotherapy. The pelvic lymphnodes, prostate and seminal vesicles were treated with external beam radiotherapy (EBRT) to an absorbed dose of 50 Gy followed by a brachytherapy (BT) boost of 2x10 Gy to the prostate only. Twenty-two patients accepted an invitation to a clinical examination with focus on lower limb swelling. The median time between the end of radiotherapy and examination was 2.2 years (range 1.2-4.1). Results: Six patients (27%) experienced grade 1 lymphedema and two patients (9%) grade 2 while none had grade 3 or 4 according to the CTC Common Toxicity Criteria scale 4.0. Three patients required treatment with compression stockings. Conclusion: Brachytherapy and pelvic EBRT have a low incidence of lymphedema (at median 2.2 y after treatment) in patients with high-risk node-positive prostate cancer that have undergone pelvic lymph node dissection.},
  author       = {Rasmusson, Elisabeth and Gunnlaugsson, Adalsteinn and Blom, René and Bojrk-Eriksson, Thomas and Nilsson, Per and Ahlgren, Göran and Jönsson, Charlotta and Johansson, Karin and Kjellén, Elisabeth},
  issn         = {1748-717X},
  language     = {eng},
  publisher    = {BioMed Central (BMC)},
  series       = {Radiation Oncology},
  title        = {Low rate of lymphedema after extended pelvic lymphadenectomy followed by pelvic irradiation of node-positive prostate cancer},
  url          = {https://lup.lub.lu.se/search/ws/files/3661241/4588208},
  doi          = {10.1186/1748-717X-8-271},
  volume       = {8},
  year         = {2013},
}