High circulating levels of midregional proenkephalin A predict vascular dementia : a population-based prospective study
(2020) In Scientific Reports 10(1).- Abstract
Midregional Pro-enkephalin A (MR-PENK A) and N-terminal Protachykinin A (NT-PTA) have been associated with vascular dementia. However, the longitudinal relationship between these biomarkers and incident dementia has not been fully investigated. In the population-based Malmö Preventive Project, circulating levels of MR-PENK A and NT-PTA were determined in a random sample of 5,323 study participants (mean age: 69 ± 6 years) who were followed-up over a period of 4.6 ± 1.6 years. The study sample included 369 patients (7%) who were diagnosed in the same period with dementia. We analyzed relationship of MR-PENK A and NT-PTA with the risk of developing dementia by using multivariable-adjusted Cox regression models adjusted for traditional... (More)
Midregional Pro-enkephalin A (MR-PENK A) and N-terminal Protachykinin A (NT-PTA) have been associated with vascular dementia. However, the longitudinal relationship between these biomarkers and incident dementia has not been fully investigated. In the population-based Malmö Preventive Project, circulating levels of MR-PENK A and NT-PTA were determined in a random sample of 5,323 study participants (mean age: 69 ± 6 years) who were followed-up over a period of 4.6 ± 1.6 years. The study sample included 369 patients (7%) who were diagnosed in the same period with dementia. We analyzed relationship of MR-PENK A and NT-PTA with the risk of developing dementia by using multivariable-adjusted Cox regression models adjusted for traditional risk factors. Increased plasma levels of MR-PENK A were associated with higher risk of incident vascular dementia whereas no associations were found with all-cause or Alzheimer dementia. The risk of vascular dementia was mainly conferred by the highest quartile of MR-PENK as compared with lower quartiles. Elevated levels of NT-PTA yielded significant association with all-cause dementia or dementia subtypes. Elevated plasma concentration of MR-PENK A independently predicts vascular dementia in the general population. MR-PENK A may be used as an additional tool for identifying vascular subtype in ambiguous dementia cases.
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- author
- Holm, H LU ; Nägga, K LU ; Nilsson, E D ; Ricci, F LU ; Melander, O LU ; Hansson, O LU ; Bachus, E LU ; Fedorowski, A LU and Magnusson, M LU
- organization
- publishing date
- 2020-05-15
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- BIOMARKERS
- in
- Scientific Reports
- volume
- 10
- issue
- 1
- article number
- 8027
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85084845066
- pmid:32415209
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-020-64998-y
- language
- English
- LU publication?
- yes
- id
- 7a722090-bf22-402e-88ef-f92f09ba14f8
- date added to LUP
- 2020-05-19 08:49:39
- date last changed
- 2024-03-13 10:45:22
@article{7a722090-bf22-402e-88ef-f92f09ba14f8, abstract = {{<p>Midregional Pro-enkephalin A (MR-PENK A) and N-terminal Protachykinin A (NT-PTA) have been associated with vascular dementia. However, the longitudinal relationship between these biomarkers and incident dementia has not been fully investigated. In the population-based Malmö Preventive Project, circulating levels of MR-PENK A and NT-PTA were determined in a random sample of 5,323 study participants (mean age: 69 ± 6 years) who were followed-up over a period of 4.6 ± 1.6 years. The study sample included 369 patients (7%) who were diagnosed in the same period with dementia. We analyzed relationship of MR-PENK A and NT-PTA with the risk of developing dementia by using multivariable-adjusted Cox regression models adjusted for traditional risk factors. Increased plasma levels of MR-PENK A were associated with higher risk of incident vascular dementia whereas no associations were found with all-cause or Alzheimer dementia. The risk of vascular dementia was mainly conferred by the highest quartile of MR-PENK as compared with lower quartiles. Elevated levels of NT-PTA yielded significant association with all-cause dementia or dementia subtypes. Elevated plasma concentration of MR-PENK A independently predicts vascular dementia in the general population. MR-PENK A may be used as an additional tool for identifying vascular subtype in ambiguous dementia cases.</p>}}, author = {{Holm, H and Nägga, K and Nilsson, E D and Ricci, F and Melander, O and Hansson, O and Bachus, E and Fedorowski, A and Magnusson, M}}, issn = {{2045-2322}}, keywords = {{BIOMARKERS}}, language = {{eng}}, month = {{05}}, number = {{1}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{High circulating levels of midregional proenkephalin A predict vascular dementia : a population-based prospective study}}, url = {{http://dx.doi.org/10.1038/s41598-020-64998-y}}, doi = {{10.1038/s41598-020-64998-y}}, volume = {{10}}, year = {{2020}}, }