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High circulating levels of midregional proenkephalin A predict vascular dementia : a population-based prospective study

Holm, H LU ; Nägga, K LU ; Nilsson, E D ; Ricci, F LU ; Melander, O LU orcid ; Hansson, O LU orcid ; Bachus, E LU ; Fedorowski, A LU orcid and Magnusson, M LU orcid (2020) In Scientific Reports 10(1).
Abstract

Midregional Pro-enkephalin A (MR-PENK A) and N-terminal Protachykinin A (NT-PTA) have been associated with vascular dementia. However, the longitudinal relationship between these biomarkers and incident dementia has not been fully investigated. In the population-based Malmö Preventive Project, circulating levels of MR-PENK A and NT-PTA were determined in a random sample of 5,323 study participants (mean age: 69 ± 6 years) who were followed-up over a period of 4.6 ± 1.6 years. The study sample included 369 patients (7%) who were diagnosed in the same period with dementia. We analyzed relationship of MR-PENK A and NT-PTA with the risk of developing dementia by using multivariable-adjusted Cox regression models adjusted for traditional... (More)

Midregional Pro-enkephalin A (MR-PENK A) and N-terminal Protachykinin A (NT-PTA) have been associated with vascular dementia. However, the longitudinal relationship between these biomarkers and incident dementia has not been fully investigated. In the population-based Malmö Preventive Project, circulating levels of MR-PENK A and NT-PTA were determined in a random sample of 5,323 study participants (mean age: 69 ± 6 years) who were followed-up over a period of 4.6 ± 1.6 years. The study sample included 369 patients (7%) who were diagnosed in the same period with dementia. We analyzed relationship of MR-PENK A and NT-PTA with the risk of developing dementia by using multivariable-adjusted Cox regression models adjusted for traditional risk factors. Increased plasma levels of MR-PENK A were associated with higher risk of incident vascular dementia whereas no associations were found with all-cause or Alzheimer dementia. The risk of vascular dementia was mainly conferred by the highest quartile of MR-PENK as compared with lower quartiles. Elevated levels of NT-PTA yielded significant association with all-cause dementia or dementia subtypes. Elevated plasma concentration of MR-PENK A independently predicts vascular dementia in the general population. MR-PENK A may be used as an additional tool for identifying vascular subtype in ambiguous dementia cases.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
BIOMARKERS
in
Scientific Reports
volume
10
issue
1
article number
8027
publisher
Nature Publishing Group
external identifiers
  • scopus:85084845066
  • pmid:32415209
ISSN
2045-2322
DOI
10.1038/s41598-020-64998-y
language
English
LU publication?
yes
id
7a722090-bf22-402e-88ef-f92f09ba14f8
date added to LUP
2020-05-19 08:49:39
date last changed
2024-03-13 10:45:22
@article{7a722090-bf22-402e-88ef-f92f09ba14f8,
  abstract     = {{<p>Midregional Pro-enkephalin A (MR-PENK A) and N-terminal Protachykinin A (NT-PTA) have been associated with vascular dementia. However, the longitudinal relationship between these biomarkers and incident dementia has not been fully investigated. In the population-based Malmö Preventive Project, circulating levels of MR-PENK A and NT-PTA were determined in a random sample of 5,323 study participants (mean age: 69 ± 6 years) who were followed-up over a period of 4.6 ± 1.6 years. The study sample included 369 patients (7%) who were diagnosed in the same period with dementia. We analyzed relationship of MR-PENK A and NT-PTA with the risk of developing dementia by using multivariable-adjusted Cox regression models adjusted for traditional risk factors. Increased plasma levels of MR-PENK A were associated with higher risk of incident vascular dementia whereas no associations were found with all-cause or Alzheimer dementia. The risk of vascular dementia was mainly conferred by the highest quartile of MR-PENK as compared with lower quartiles. Elevated levels of NT-PTA yielded significant association with all-cause dementia or dementia subtypes. Elevated plasma concentration of MR-PENK A independently predicts vascular dementia in the general population. MR-PENK A may be used as an additional tool for identifying vascular subtype in ambiguous dementia cases.</p>}},
  author       = {{Holm, H and Nägga, K and Nilsson, E D and Ricci, F and Melander, O and Hansson, O and Bachus, E and Fedorowski, A and Magnusson, M}},
  issn         = {{2045-2322}},
  keywords     = {{BIOMARKERS}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{High circulating levels of midregional proenkephalin A predict vascular dementia : a population-based prospective study}},
  url          = {{http://dx.doi.org/10.1038/s41598-020-64998-y}},
  doi          = {{10.1038/s41598-020-64998-y}},
  volume       = {{10}},
  year         = {{2020}},
}