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Familial risks for hospitalization with endocrine diseases

Hemminki, Kari LU ; Shu, Xiaochen LU ; Li, Xinjun LU ; Ji, Jianguang LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2008) In Journal of Clinical Endocrinology and Metabolism 93(12). p.4755-4758
Abstract

Context: Familial clustering of a disease is an indicator of a possible heritable cause. In the era of genome scans, the consideration of data on heritability should be important in the assessment of the likely success of the scans. Object: The objective of the study was to carry out a family study on nonthyroid endocrine diseases to search familial clustering of these diseases beyond the known syndromes. Design and Setting: The Swedish Multigeneration Register on 0- to 72-yr-old subjects was linked to the Hospital Discharge Register from years 1964 to 2004. Main Outcome Measure: Standardized incidence ratios were calculated for offspring of affected parents and siblings by comparing with those whose relatives had no hospitalization for... (More)

Context: Familial clustering of a disease is an indicator of a possible heritable cause. In the era of genome scans, the consideration of data on heritability should be important in the assessment of the likely success of the scans. Object: The objective of the study was to carry out a family study on nonthyroid endocrine diseases to search familial clustering of these diseases beyond the known syndromes. Design and Setting: The Swedish Multigeneration Register on 0- to 72-yr-old subjects was linked to the Hospital Discharge Register from years 1964 to 2004. Main Outcome Measure: Standardized incidence ratios were calculated for offspring of affected parents and siblings by comparing with those whose relatives had no hospitalization for nonthyroid endocrine diseases. Results: A total of 11,948 hospitalized cases and 443 familial cases were identified. The familial standardized incidence ratios were increased for parathyroid, pituitary, and adrenal hyperfunctions and hypofunctions, some findings consistent with known syndromes, most clearly that for adrenal cortical hypofunction showing recessive inheritance described for autoimmune polyendocrine syndrome 1. The sibling risks were very high for many diseases, but some of these affecting young individual may be due to bias caused by selective hospitalization. A high sibling risk observed for anterior pituitary hypofunction may represent a yet-unknown recessive syndrome. Conclusions: To our knowledge this is a first population-based study on nonthyroid endocrine diseases. The results call for further studies to sort out the challengingly high sibling risk for many individual nonthyroid endocrine diseases, whether they are due to bias or possible recessive effects.

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author
publishing date
type
Contribution to journal
publication status
published
in
Journal of Clinical Endocrinology and Metabolism
volume
93
issue
12
pages
4 pages
publisher
The Endocrine Society
external identifiers
  • scopus:57349150251
  • pmid:18827002
ISSN
0021-972X
DOI
10.1210/jc.2008-1210
language
English
LU publication?
no
id
7ab5b822-ef0e-459b-8e6d-3c8321ca486b
date added to LUP
2019-01-30 10:41:06
date last changed
2020-01-13 01:24:51
@article{7ab5b822-ef0e-459b-8e6d-3c8321ca486b,
  abstract     = {<p>Context: Familial clustering of a disease is an indicator of a possible heritable cause. In the era of genome scans, the consideration of data on heritability should be important in the assessment of the likely success of the scans. Object: The objective of the study was to carry out a family study on nonthyroid endocrine diseases to search familial clustering of these diseases beyond the known syndromes. Design and Setting: The Swedish Multigeneration Register on 0- to 72-yr-old subjects was linked to the Hospital Discharge Register from years 1964 to 2004. Main Outcome Measure: Standardized incidence ratios were calculated for offspring of affected parents and siblings by comparing with those whose relatives had no hospitalization for nonthyroid endocrine diseases. Results: A total of 11,948 hospitalized cases and 443 familial cases were identified. The familial standardized incidence ratios were increased for parathyroid, pituitary, and adrenal hyperfunctions and hypofunctions, some findings consistent with known syndromes, most clearly that for adrenal cortical hypofunction showing recessive inheritance described for autoimmune polyendocrine syndrome 1. The sibling risks were very high for many diseases, but some of these affecting young individual may be due to bias caused by selective hospitalization. A high sibling risk observed for anterior pituitary hypofunction may represent a yet-unknown recessive syndrome. Conclusions: To our knowledge this is a first population-based study on nonthyroid endocrine diseases. The results call for further studies to sort out the challengingly high sibling risk for many individual nonthyroid endocrine diseases, whether they are due to bias or possible recessive effects.</p>},
  author       = {Hemminki, Kari and Shu, Xiaochen and Li, Xinjun and Ji, Jianguang and Sundquist, Jan and Sundquist, Kristina},
  issn         = {0021-972X},
  language     = {eng},
  month        = {01},
  number       = {12},
  pages        = {4755--4758},
  publisher    = {The Endocrine Society},
  series       = {Journal of Clinical Endocrinology and Metabolism},
  title        = {Familial risks for hospitalization with endocrine diseases},
  url          = {http://dx.doi.org/10.1210/jc.2008-1210},
  doi          = {10.1210/jc.2008-1210},
  volume       = {93},
  year         = {2008},
}